A5085951052- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Histone Deacetylase Inhibitors Research
- Acupuncture Treatment Research Studies
- Nanoplatforms for cancer theranostics
- Receptor Mechanisms and Signaling
- Intracranial Aneurysms: Treatment and Complications
- Immunotherapy and Immune Responses
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune cells in cancer
- Traditional Chinese Medicine Studies
- Hormonal Regulation and Hypertension
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Healthcare and Venom Research
- Epigenetics and DNA Methylation
- Nanocluster Synthesis and Applications
- Telomeres, Telomerase, and Senescence
- Cerebrovascular and Carotid Artery Diseases
- Cellular transport and secretion
- Adenosine and Purinergic Signaling
- Advanced Glycation End Products research
- Renal and Vascular Pathologies
Southeast University
2018-2025
Suqian University
2023-2025
Chengdu University of Traditional Chinese Medicine
2020-2025
Shanghai Jiao Tong University
2022-2025
Shanghai First People's Hospital
2025
Ministry of Agriculture and Rural Affairs
2025
Zhejiang University
2024-2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Fujian Agriculture and Forestry University
2024
Sun Yat-sen University
2008-2024
Increasing evidence suggests that 5-HT 1A receptor (5-HT R) is implicated in anxiety disorders. However, the mechanism underlying role of R these diseases remains unknown. Here, we show R-selective agonist 8-OH-DPAT and selective serotonin reuptake inhibitor (SSRI) fluoxetine downregulated hippocampal neuronal nitric oxide synthase (nNOS) expression, whereas antagonist NAN-190 upregulated nNOS expression. By assessing anxiety-related behaviors using novelty suppressed feeding, open-field,...
The molecular mechanisms underlying the behavioral effects of glucocorticoids are poorly understood. We report here that hippocampal neuronal nitric oxide synthase (nNOS) is a crucial mediator. Chronic mild stress and exposures caused nNOS overexpression via activating mineralocorticoid receptor. In turn, nNOS-derived (NO) significantly downregulated local glucocorticoid receptor expression through both soluble guanylate cyclase (sGC)/cGMP peroxynitrite (ONOO − )/extracellular...
Natural evolution has resulted in reduced cold tolerance cultivated tomato (Solanum lycopersicum). Herein, we perform a combined analysis of ATAC-Seq and RNA-Seq cold-sensitive cold-tolerant wild (S. habrochaites). We identify that WRKY34 the most significant association with differential chromatin accessibility expression patterns under stress. find 60 bp InDel promoter causes differences its transcription among 376 accessions. This fragment contains GATA cis-regulatory element binds to...
Telomere and telomerase alterations have been reported in mood disorders. However, the role of depression remains unclear. Here we show that chronic mild stress (CMS) led to a significant decrease reverse transcriptase (TERT) level activity hippocampus. Treatment with antidepressant fluoxetine reversed CMS-induced TERT changes. Inhibiting by systemic administration (100 mg · kg −1 d , i.p., for 14 d), intrahippocampal microinjection (0.7 μmol, 2 μl), or infusion (using an osmotic minipump,...
Mechanisms underlying the female preponderance in affective disorders are poorly understood. Here we show that hippocampal nitric oxide (NO) plays a role sex difference of depression-like behaviors rodents. Female mice had substantially lower NO production hippocampus and were significantly more likely to display negative than their male littermates. Eliminating basal level between mended gap behaviors. Estradiol exerted positive control on via estrogen receptor-β–mediated neuronal synthase...
Drug-induced renal failure (DIRF) poses a serious medical complication with high mortality risk. However, early diagnosis or prognosis of DIRF remain challenging, as current methods rely on detecting late-stage biomarkers. Herein we present library zwitterionic unimolecular hemicyanines (ZCs) available for constructing activatable reporters to detect since its initial stage. Zwitterionic properties these probes are achieved through interspersedly integrating alkyl sulfonates and quaternary...
Chemiluminescence imaging has been recognized as a valuable tool for ultrasensitive detection of physio-pathological events through elimination background autofluorescence. However, most chemiluminescent nanoprobes suffer from shallow depths and slow clearance living bodies, which impede their use in clinical settings. We herein report size-transformable nanoreporters (ADN1 ADN2) that could be activated at disease site by superoxide anion (O2 ⋅- ) to trigger nanostructure disassembly into...
Abstract Serotonin 1a-receptor (5-HT1aR) has been specifically implicated in the pathogenesis of anxiety. However, mechanism underlying role 5-HT1aR anxiety remains poorly understood. Here we show mice that transcription factor cAMP response element binding protein (CREB) hippocampus functions as an effector modulating anxiety-related behaviors. We generated recombinant lentivirus LV-CREB133-GFP expressing a dominant negative CREB which could not be phosphorylated at Ser133 to reduce...
Sugar polymer–engineered dendritic cells promote the activation of T cells.
Abstract Iron metabolism disorders are implicated in the pathogenesis of Alzheimer’s disease (AD). It was previously reported that transferrin receptor (TFR1) expression upregulated AD mouse model. However, precise biological functions TFR1 progression remains unclear. Herein, we observed a gradual increase protein during differentiation patient-derived induced pluripotent stem cells (AD-iPS). knockdown inhibited ferritin and heavy chain 1 (FTH1), enhanced ferroportin (FPN1), decreased...
Abstract Background Cellular senescence refers to cells entering a relatively stable state of cell cycle arrest, which is barrier that tumor must cross achieve immortalization and plays an extremely important role in preventing the occurrence development tumors. In recent years, numerous studies have shown inducing enter senescent has become feasible control strategy. At present, cellular research hotspot prevention treatment, as well biology. However, expression prognostic values genes head...
Acupoint Zusanli (ST36) has been shown to reduce blood pressure, but the underlying mechanism remains unknown. This study aimed characterize effects of manual acupuncture (MA) at ST36 on BP and its associated mechanisms in anesthetized rats. The cardiovascular response MA Sprague-Dawley rats was measured by electrocardiogram, hemodynamic methods, heart rate variability, echocardiography, laser speckle contrast imaging, Western blotting. RNA sequencing employed for mechanistic investigation,...
Colorectal cancer (CRC) is a prevalent malignancy worldwide, often treated with chemotherapy despite its limitations, including adverse effects and resistance. The traditional Chinese medicine (TCM) Jianpi formula has been demonstrated to improve efficacy of chemotherapy, however the underlying mechanisms still need be explored. In this study, we aim screen bioactive peptides derived from blood CRC patients through peptidomics explore molecular candidate in inhibition using multi-omics...
Dermal Papilla Cells (DPCs) play a crucial role in regulating hair follicle development and serve as valuable vitro model for screening analyzing the genes associated with this process. However, current methods isolating ovine DPCs primarily rely on mechanical techniques, which present several limitations. The aim of study is to establish method culturing high purity retains their intrinsic properties. We identified sheep DPC membrane-specific using single-cell transcriptomic data, validated...