A5101918495- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Microbial infections and disease research
- Virus-based gene therapy research
- Aquaculture disease management and microbiota
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- interferon and immune responses
- Probiotics and Fermented Foods
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- T-cell and Retrovirus Studies
- Virology and Viral Diseases
- Reproductive System and Pregnancy
- Viral Infections and Vectors
- Diagnosis and treatment of tuberculosis
- Vector-Borne Animal Diseases
- Antimicrobial Peptides and Activities
- Yersinia bacterium, plague, ectoparasites research
- Vector-borne infectious diseases
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
Gansu Agricultural University
2015-2024
Influenza A virus (IAV) is a globally distributed zoonotic pathogen and causes highly infectious respiratory disease with high morbidity mortality in humans animals. IAV has evolved various strategies to counteract the innate immune response, using different viral proteins. However, mechanisms are not fully elucidated. In this study, we demonstrated that nonstructural protein 2 (NS2) of H1N1 negatively regulate induction type-I interferon. Co-immunoprecipitation experiments revealed NS2...
African swine fever virus (ASFV) is an important pathogen that causes a highly contagious and lethal disease in swine, for which neither vaccine nor treatment available. The DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1), excises the oxidative base lesion 8-oxo-7,8-dihydroguanine (8-oxoG), has been linked to pathogenesis of different diseases associated with viral infections. However, role OGG1-base excision (BER) ASFV infection poorly investigated. Our study aimed characterize...
Bovine tuberculosis (bTB) caused by Mycobacterium bovis ( M . ) represents one of major zoonotic diseases among cattle, it also affects the health human, other domestic animals and wild life populations. Inhalation infected aerosol droplets is considered as most frequent route infection. This study aims to investigate current forms in cattle identify possible transmission modes dairy farms China. 13,345 cows from eight three provinces were comprehensively diagnosed a multitude assays,...
Tuberculosis (TB), a contagious disease mainly caused by Mycobacterium tuberculosis ( M . tb ), bovis and caprae poses major global threat to the health of humans many species animals. Developing an ante-mortem detection technique for different would be significance in improving surveillance employing One Health strategy. To achieve this goal, universal indirect ELISA was established serologically detecting complex infection multiple live hosts using fusion protein MPB70, MPB83, ESAT6, CFP10...
Summary: Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTBC), poses a major global threat to health of humans and animals. The Suidae family is highly susceptible TB used as screening sentinels for testing presence MTBC in environment, but swine (STB) tends be neglected worldwide. China has largest pig population world, epidemiological information on STB scarce. In this study, 1379 serum samples were randomly collected from 45 herds Gansu province, February June 2021...
Influenza A viruses (IAVs) possess variable pathogenic potency causing great economic losses in the poultry industry worldwide and threatening public health. The control of IAV epidemics desperately necessitates an efficient platform for screening antiviral compounds evaluating vaccine efficacy. In this study, we utilized H9N2 subtype as working model. An 11-amino-acid HiBiT tag, derived from NanoLuc luciferase, was incorporated into flexible linker region NS1 protein. Subsequently,...