A5101677525- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Analysis
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Silymarin and Mushroom Poisoning
- Physiological and biochemical adaptations
- Flavonoids in Medical Research
- Heat shock proteins research
- Genetic Syndromes and Imprinting
- Neurological diseases and metabolism
- Genetic and phenotypic traits in livestock
- Nicotinic Acetylcholine Receptors Study
- Phosphodiesterase function and regulation
- Neurogenesis and neuroplasticity mechanisms
- Energetic Materials and Combustion
- Bipolar Disorder and Treatment
- Nanomaterials for catalytic reactions
- Meat and Animal Product Quality
- Olfactory and Sensory Function Studies
- thermodynamics and calorimetric analyses
- Autophagy in Disease and Therapy
- Neurological disorders and treatments
- Sirtuins and Resveratrol in Medicine
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
National Center for Drug Screening
2021
Université de Montréal
1994-1996
Hôtel-Dieu de Montréal
1995-1996
To assess the effectiveness of nifedipine treatment in elderly hypertensives.A single-blind trial was conducted under direction Shanghai Institute Hypertension 1632 subjects aged 60-79 years alternatively allocated to either or placebo after a 4-week run-in period between 1987 and 1990 with mean follow-up 30 months. Clinical events risk modification were analysed collaboration University Montreal. Seventy-four patients severe hypertension reallocated active run-in.Cox's proportional hazards...
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in world. In addition to motor symptoms, a variety of non-motor symptoms seriously affect life quality PD patients. Baicalein, flavonoid extracted from herb Scutellaria baicalensis Georgi, exhibits anti-PD activity through alleviation its symptoms. However, effects on were barely reported. This study aimed investigate therapeutic baicalein PD-related depression. After 2-week injection rotenone, mice with...
Heart failure with preserved ejection fraction (HFpEF) is a morbid, fatal, and common syndrome for which lack of evidence-based therapies. Salvianolic acid A (SAA), major active ingredient Salvia miltiorrhiza Burge, has shown potential to protect against cardiovascular diseases. This study aims elucidate whether SAA possessed therapeutic activity HFpEF explore the mechanism. mouse model was established infusing combination high-fat diet (HFD) Nω-nitro-L-arginine methyl ester (L-NAME) 14...
Salvianolic acid A (SAA) is a traditional Chinese medicine that has good therapeutic effect on cardiovascular disease. However, the underlying mechanisms by which SAA improves mitochondrial respiration and cardiac function in diabetic cardiomyopathy (DCM) remain unknown. This study aims to elucidate whether had any protection pathophysiology of DCM explored potential mechanisms. Diabetes was induced rats 30 mg/kg streptozotocin (STZ) treatment. After week stability, 5 isoprenaline (ISO)...
Inflammatory response participates in the overall pathophysiological process of stroke. It is a promising strategy to develop antistroke drugs targeting inflammation. This study aimed at investigating therapeutic effect and anti-inflammatory mechanism salvianolic acid D (SalD) against cerebral ischemia/reperfusion (I/R) injury. A rat middle artery occlusion/reperfusion (MCAO/R) injury model was established, an oxygen-glucose deprivation/reoxygenation (OGD/R) established PC12 cells....
Drug combinations have been the hotspot of pharmaceutical industry, but promising applications are limited by unmet solubility and low bioavailability. In this work, novel cocrystals, consisting two antithrombotic drugs with poor bioavailability in vivo, namely, apixaban (Apx) quercetin (Que), were developed to discover a potential method improve internal absorption drug combination. Compared Apx, dissolution behavior Apx–Que (1:1) Apx–Que–2ACN (1:1:2) was enhanced significantly, while...
Nicotinic α4β2 receptor antagonists have drawn increasing attention in the development of new antidepressants. In this study, we aimed to investigate protective effect VMY-2-95, selective antagonist nicotinic acetylcholine (nAChR) on corticosterone (CORT) injured mice and cellular models. Fluoxetine was applied as a positive control, effects VMY-2-95 were investigated with three different doses or concentrations (1, 3, 10 mg/kg mice, 0.003, 0.03, 0.1 μmol/L cells). As result, showed...
Abstract The heterogeneity of Parkinson’s disease (PD) has been recognized in clinical, with patients categorized into distinct subsets based on motor phenotype, such as tremor-dominant PD (TD), postural instability and gait difficulty-dominant (PIGD) mixed (Mix). Despite this categorization, the underlying mechanisms remain poorly understood, there is no personalized effective treatment for each subtype. To address this, a rat model subtypes was established by unilateral stereotaxic...
SUMMARY 1. A significant portion of blood pressure variance is modified by the environment. 2. The present report summarizes evidence that: (i) environmental response genetically determined; (ii) various stressors can evoke a differential in hypertensive animals and constitute its intermediate phenotypes; (iii) to heat stress be assigned single ‘thermosensitivity’ locus; (iv) candidate genes susceptibility stresses are member(s) gene ( HSP ) families; (v) restriction fragment length...
Nano-FeOOH catalysts were prepared by a co-precipitation method and characterized XRD, SEM, XPS BET to analyze the phase composition, surface morphology, elemental composition specific area of FeOOH. Results showed that FeOOH catalyst had large pore volume area, providing more active sites for catalytic reactions. A 3D electrocatalytic system EC/PS/FeOOH was established degrade tetracycline (TC), contributions adsorption, PS activation electrocatalysis investigated. It found adsorption rate...