A5027108047- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Hedgehog Signaling Pathway Studies
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- interferon and immune responses
- Phytase and its Applications
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- RNA Interference and Gene Delivery
- IgG4-Related and Inflammatory Diseases
- Genetic and Kidney Cyst Diseases
- Pancreatic and Hepatic Oncology Research
- Mast cells and histamine
- Proteoglycans and glycosaminoglycans research
- Pediatric Hepatobiliary Diseases and Treatments
- Oral and gingival health research
Qilu Hospital of Shandong University
2021-2024
Background & Aims: Cholangiocarcinoma (CCA) is a highly lethal malignancy originating from the biliary ducts. Current CCA diagnostic and prognostic assessments cannot satisfy clinical requirement. Bile detection rarely performed, herein, we aim to estimate significance of bile liquid biopsy by assessing exosomal concentrations components. Approach Results: Exosomes in sera CCA, pancreatic cancer, common duct stone were identified quantified transmission electronmicroscopy, nanoparticle...
Objective The correlation between cholangiocarcinoma (CCA) progression and bile is rarely studied. Here, we aimed to identify differential metabolites in benign malignant ducts elucidate the generation, function degradation of metabolites. Design Differential from CCA biliary stenosis were identified by metabonomics. Biliary molecules able induce mast cell (MC) degranulation revealed vitro vivo experiments, including liquid chromatography-mass spectrometry (MS)/MS bioluminescence resonance...
Aldehyde dehydrogenases (ALDHs) play an essential role in regulating malignant tumor progression; however, their cholangiocarcinoma (CCA) has not been elucidated. We analyzed the expression of ALDHs 8 paired and peritumor perihilar (pCCA) tissues found that ALDH3B1 ALDH3B2 were upregulated tissues. Further survival analysis intrahepatic (iCCA, n = 27), pCCA (n 87) distal (dCCA, 80) cohorts have revealed was a prognostic factor CCA independent iCCA pCCA. associated with serum CEA dCCA, T...
Abstract and Aim: Cholangiocarcinoma (CCA) is a highly aggressive lethal cancer that originates from the biliary epithelium. Systemic treatment options for CCA are currently limited, first targeted drug of CCA, pemigatinib, emerged in 2020 by inhibiting FGFR2 phosphorylation. However, regulatory mechanism phosphorylation not fully elucidated. Approach Results: Here we screened FGFR2-interacting proteins showed protein tyrosine phosphatase (PTP) N9 interacts with negatively regulates...
Cholangiocarcinoma (CCA), an exceptionally aggressive malignancy originating from the epithelium of bile duct, poses a formidable challenge in cancer research and clinical management. Currently, attention is focused on exploring oncogenic role prognostic implications associated with Bmi1 context CCA. In our study, we assessed correlation Foxn2 expression across all types CCA evaluated their significance. Our results demonstrated that exhibits significantly upregulated tissues, while shows...
SMAD4 is a tumour suppressor and an important regulator of immune scape which downregulated in cholangiocarcinoma (CCA). STING1 vital sensing factor abnormal DNA; however, the correlation between role SMAD4-STING1 interaction progression CCA have not yet been evaluated. Public database was analysed to reveal expression STING1. A cohort comprising 50 iCCA, 113 pCCA 119 dCCA patients assembled for study. Immunohistochemistry employed evaluate levels SMAD4. In vitro transwell CCK8 assays, along...
Biliary cystadenoma (also called mucinous cystic neoplasm with low-grade intraepithelial neoplasia) is a rare tumor that arises from the biliary epithelium. The cause of still unclear. Jaundice presentation intrahepatic cystadenoma, which can lead to diagnostic dilemma. Herein, we present case primarily exhibited as jaundice. A 56-year-old woman has suffered yellow staining her skin and sclera for more than 1 month. She had poor appetite mild epigastric pain. Laboratory examination showed...
Background Hepatocellular carcinoma (HCC) is the most common primary liver cancer and often arises in context of chronic disease, such as hepatitis B or C infection, cirrhosis. Advanced unresectable HCC (uHCC) presents significant treatment challenges due to its advanced stage inoperability. One efficient method for uHCC use hepatic arterial infusion chemotherapy (HAIC) combined with transcatheter embolization (TAE). Patients Methods In this study, we conducted a retrospective collection...
Abstract Background: Cholangiocarcinoma (CCA) is a class of malignant tumors originating from bile duct epithelial cells. Due to difficult early diagnosis and limited treatment, the prognosis CCA extremely poor. Bmi1 dysregulated in many human malignancies. However, prognostic significance oncogenic role cholangiocarcinoma are not well elucidated. Methods: In present study, we investigated its clinical importance potential mechanisms progression CCA. We detected expression large cohort....
Abstract Background: Cholangiocarcinoma (CCA) is a class of malignant tumors originating from bile duct epithelial cells. Due to difficult early diagnosis and limited treatment, the prognosis CCA extremely poor. BMI1 dysregulated in many human malignancies. However, prognostic significance oncogenic role cholangiocarcinoma are not well elucidated. Methods: In present study, we investigated its clinical importance potential mechanisms progression CCA. We detected expression large cohort....