A5114116822- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Light effects on plants
- Dielectric materials and actuators
- Proteoglycans and glycosaminoglycans research
- Aluminum Alloy Microstructure Properties
- Advanced Sensor and Energy Harvesting Materials
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- Radiation Dose and Imaging
- Polymer Nanocomposites and Properties
- Natural Compounds in Disease Treatment
- Biopolymer Synthesis and Applications
- COVID-19 Impact on Reproduction
- Dental Radiography and Imaging
- DNA and Nucleic Acid Chemistry
- IgG4-Related and Inflammatory Diseases
- COVID-19 Clinical Research Studies
- Forest, Soil, and Plant Ecology in China
- Autoimmune and Inflammatory Disorders Research
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Lung Cancer Treatments and Mutations
- Heart Rate Variability and Autonomic Control
Henan Provincial People's Hospital
2023-2024
Zhengzhou University
2023-2024
University of Chinese Academy of Sciences
2024
Qilu Hospital of Shandong University
2023-2024
Southern Medical University
2017-2023
Shaanxi University of Science and Technology
2022
China Medical University
2005
Background & Aims: Cholangiocarcinoma (CCA) is a highly lethal malignancy originating from the biliary ducts. Current CCA diagnostic and prognostic assessments cannot satisfy clinical requirement. Bile detection rarely performed, herein, we aim to estimate significance of bile liquid biopsy by assessing exosomal concentrations components. Approach Results: Exosomes in sera CCA, pancreatic cancer, common duct stone were identified quantified transmission electronmicroscopy, nanoparticle...
Hepatocellular carcinoma (HCC) is one of most common and deadliest malignancies. Celastrol (Cel), a natural product derived from the Tripterygium wilfordii plant, has been extensively researched for its potential effectiveness in fighting cancer. However, clinical application hindered by unclear mechanism action. Here, we used chemical proteomics to identify direct targets Cel enhanced targetability anti-tumor capacity developing Cel-based liposomes HCC. We demonstrated that selectively...
The small molecule epiberberine (EPI) is a natural alkaloid with versatile bioactivities against several diseases including cancer and bacterial infection. EPI can induce the formation of unique binding pocket at 5′ side human telomeric G-quadruplex (HTG) sequence four repeats (Q4), resulting in nanomolar affinity (KD approximately 26 nM) significant fluorescence enhancement upon binding. It important to understand (1) how affects HTG structural stability (2) enhanced may be achieved through...
Hemophagocytic syndrome (HPS) is a rapidly progressive and highly fatal disease, even more complex when it occurs during pregnancy. Currently, the HLH-94 protocol commonly used for treatment HPS, with ruxolitinib being mostly salvage therapy. Here, we report pregnant woman who presented fever, thrombocytopenia, splenomegaly, subsequently developed into severe pneumonia multiple organ dysfunction(MODS). The patient was diagnosed as HPS based on clinical manifestations, laboratory indexes,...
ABSTRACT Background With the increasing use of lung cancer screening, detection ground glass nodules (GGNs) has risen. However, natural course GGNs and their relationship to pathologic features remains unclear. Differentiating between invasive pre‐invasive lesions based on GGN growth may improve clinical intervention timing. Ki‐67, a proliferation marker, holds value in assessing tumor malignancy. This study analyzes association growth, pathology, Ki‐67 expression provide new insights into...
To the Editor: The vaccine-related adaptive immune systems, including humoral immunity induced by B cell reaction and cellular T cells, are crucial for controlling severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection.[1] Therefore, it is vital to clarify changes caused inactivated vaccines, which most commonly used in China, evaluating protective effect of vaccines formulating vaccination plans. study was approved Medical Research Ethics Committee Henan Provincial People's...
The flow stress behavior and corrosive properties of Al-7Si alloy were studied by thermal compression test, electrochemical electron probe microanalysis. influences temperatures, strain rates, strains, morphology Si particles on stress-strain curves analyzed. peak unmodified-Al-7Si is higher than that Sr-modified-Al-7Si at the same deformation conditions, phenomenon obviously relevant to distribution particles. unmodified-undeformed-Al-7Si a typical thick layer, unmodified-deformed-Al-7Si...
Polymer-based materials act a crucial role in progressive electronic devices and electric power systems since their excellent ferroelectric dielectric performances. For composites containing nanofillers, extra high ferroelectricity could be achieved at even low field. Importantly, what the enhancements besides intrinsic of fillers originated from is still ambiguous. Herein, Ca2Nb3O10 (CNO) nanosheet selected as nanofillers to embedded into polyvinylidene fluoride (PVDF)-based polymer matrix....
Background: Fear is one of the most widely studied emotions and closely associated with autonomic nervous system (ANS).Previous studies have proven that acupuncture directly impacts ANS, influences heart rate (HR) variability (HRV) exerts other effects.The aim this study was to explore effect Jianshi (PC5) Neiguan (PC6) electro-acupuncture on HRV during fear-invoking auditory stimulation using an Actiheart ECG recorder. Materials Methods:Two hundred healthy subjects were recruited.Using a...
To develop submandibular gland acellular matrix and observe its structure analyze histological ingredients. METHODS: The fresh glands of SD mice were cell-extracted by chemical detergent ingredients analyzed immunohistochemistry ultra observed. RESULTS: Submandibular cells disappeared, appeared network under microscopy collagen fibers showed different diameter directions formed complicated SEM. I, II III type proteins before after positive immunohistochemistry. CONCLUSIONS: main proteins.