A5054436075- Aquaculture disease management and microbiota
- Genomics and Phylogenetic Studies
- Immune Response and Inflammation
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Antimicrobial Peptides and Activities
- SARS-CoV-2 and COVID-19 Research
- Actinomycetales infections and treatment
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Invertebrate Immune Response Mechanisms
- Antibiotic Resistance in Bacteria
- Microbial Community Ecology and Physiology
- Influenza Virus Research Studies
- Probiotics and Fermented Foods
- Remote Sensing and Land Use
- Yersinia bacterium, plague, ectoparasites research
- Bacterial Identification and Susceptibility Testing
- Aquaculture Nutrition and Growth
- Vector-borne infectious diseases
- Physiological and biochemical adaptations
- Mosquito-borne diseases and control
- Identification and Quantification in Food
Beijing Chao-Yang Hospital
2023-2025
Capital Medical University
2023-2025
Wuhan University of Technology
2025
Southwest Forestry University
2025
Sichuan Academy of Traditional Chinese Medicine
2016-2024
Huazhong Agricultural University
2013-2024
First Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
The current understanding of human gut microbial community is mainly limited to taxonomic features at the genus level. Here, we examined species level by metataxonomics. To achieve this purpose, a high-throughput approach involving operational phylogenetic unit analysis near full-length 16S ribosomal RNA (rRNA) gene sequence was used. A total 1,235 species-level phylotypes (SLPs) were classified in feces 120 Chinese healthy individuals, including 461 previously species, 358 potentially new...
Antimony (Sb) and copper (Cu) are toxic heavy metals that associated with a wide variety of minerals. Sb(III)-oxidizing bacteria convert the Sb(III) to less Sb(V) potentially useful for environmental Sb bioremediation. A total 125 culturable Sb(III)/Cu(II)-resistant from 11 different types mining soils were isolated. Four strains identified as Arthrobacter, Acinetobacter Janibacter exhibited notably high minimum inhibitory concentrations (MICs) (>10 mM),making them most highly...
Abstract During the COVID‐19 pandemic, non‐pharmaceutical interventions were introduced to reduce exposure respiratory viruses. However, these measures may have led an “immunity debt” that could make population more vulnerable. The goal of this study was examine transmission dynamics seasonal influenza in years 2023–2024. Respiratory samples from patients with influenza‐like illness collected and tested for A B electronic medical records index cases October 2023 March 2024 analyzed determine...
Abstract Phagocytosis is a fundamental immune function against foreign microorganisms and abnormal cells, it also bridge between innate adaptive immunity. Blood as the direct living environment of various cells crucial site for phagocytosis. In this review, we firstly summarized morphological structure cytochemical characteristics teleost peripheral blood divided them into erythrocytes, leucocytes thrombocytes, then systematically elaborated functions phagocytic including professional...
Abstract Type I IFNs (IFN-Is) play pivotal roles in host defense against viral infections but remain enigmatic bacterial pathogens. In this study, we recombinantly expressed and purified intact grass carp (Ctenopharyngodon idella) IFNφ1 (gcIFNφ1), a teleost IFN-I. gcIFNφ1 widely powerfully directly kills both Gram-negative Gram-positive bacteria dose-dependent manner. binds to LPS or peptidoglycan provokes membrane depolarization disruption, resulting death. Furthermore, can efficiently...
Type I interferons (IFN-Is) are critical antiviral cytokine in innate immunity but with limited direct defense ability against bacterial infections mammals. In bony fish, despite all the IFN-Is (IFN1-4) act immunity, studies demonstrate that IFN1 can remarkably contribute to host infections. this study, we found from grass carp (Ctenopharyngodon idella) contains an unusual cationic and amphipathic α-helical region (named as gcIFN-20, sequence: SYEKKINRHFKILKKNLKKK). The synthesized peptide...
Abstract Type I IFNs with strong positive charges exhibit robust bactericidal activity and a protective effect against bacterial infections. However, the antibacterial mechanism in vivo remains unknown. In this study, Ab blockade of IFN1, member type grass carp (Ctenopharyngodon idella), resulted high mortality, tissue loads, low expression immune factors after challenge, which indicates that IFN1 has physiological significance. Meanwhile, we injected recombinant purified intact protein...
ABSTRACT Grass carp reovirus (GCRV), particularly the highly prevalent type II GCRV (GCRV-II), causes huge losses in aquaculture industry. However, little is known about mechanisms by which GCRV-II invades grass and further disseminates among tissues. In present study, monocytes/macrophages (Mo/Mφs) were isolated from peripheral blood of infected with GCRV-II. The results indirect immunofluorescent microscopy, transmission electron real-time quantitative RT-PCR (qRT-PCR), western blot (WB),...
Morganella morganii is a Gram-negative, opportunistic pathogen that often associated with nosocomial infections. Here, the genomic characteristics and antimicrobial resistance (AMR) of clinical isolates between 2016 2023 were determined. A total 218 mainly identified from urinary tract (48.2%) respiratory (16.5%), 105 randomly selected for whole genome sequencing. The highest rates antibiotic observed SAM (68.3%), followed by CIP (39.9%), SXT (37.2%). Distance analysis suggested newly...
This study hypothesized that different base fertilizer application has effects on improving the efficiency of maize water utilization and promoting growth. Utilizing field positioning sloping farmland micro-zone experiments, six distinct types fertilizers were designed: a control group without fertilization (CK), chemical alone (T1), mixture local farmyard manure (40% pine needles 60% livestock manure, T2), 50% reduction in combined with (T3), incorporation crushed straw through deep plowing...
Background Chikungunya virus (CHIKV), a mosquito-borne alphavirus, is responsible for disease outbreaks worldwide. However, systematic knowledge of spatiotemporal distribution and risk patterns CHIKV in mainland Europe remains unclear. Our aim was to decipher the epidemiological characteristics, diversity, clinical manifestations CHIKV. Methods In this retrospective study, we retrieved surveillance bulletins chikungunya infections reported during 2007–2023 depict characteristics. We...
Members of Comamonas testosteroni are environmental microorganisms that usually found in polluted environment samples. They utilize steroids and aromatic compounds but rarely sugars, show resistance to multiple heavy metals drugs. However, comprehensive genomic analysis among the C. strains is lacked. To understand genome bases features testosteroni, we sequenced 10 this species analyzed them together with other related published sequences. The results revealed that: 1) have sizes ranging...
In the present study, we describe two novel Gram-stain-positive, irregular rod-shaped bacterial strains, 78T and 601, that had been isolated from faeces of Tibetan antelopes at Hoh Xil Nature Reserve, Qinghai-Tibet Plateau, China. The cells were aerobic, oxidase-negative catalase-positive. When cultured on brain-heart infusion agar supplemented with 5 % sheep blood, colonies cream in colour, circular, smooth convex. Phylogenetic analysis based full-length 16S rRNA sequences revealed type...
Quinoa (Chenopodium quinoa Willd.) is an herb of the genus Chenopodiaceae that native to Andes Mountains South America. To understand metabolic differences between various strains, we selected strains four colors (black, red, yellow, and white) subjected seeds extensive targeted metabolomics analysis using liquid chromatography-tandem mass spectrometry transcriptomics analysis. In total, 90 flavonoid-related metabolites were detected in colors. We elucida ted regulatory mechanisms flavonoid...
Abstract The major role of chemokines is to act as a chemoattractant guide the migration immune cells infectious sites. In current study, we found that CiCXCL20a, teleost-specific chemokine from grass carp (Ctenopharyngodon idella), demonstrates broad-spectrum, potent, direct bactericidal activity and immunomodulatory functions bacterial infections, apart chemotaxis. CiCXCL20a kills bacteria by binding, mainly targeting acid lipids, perforating membrane, resulting in cytoplasm leakage death....
Emerging zoonoses of wildlife origin caused by previously unknown agents are one the most important challenges for human health. The Qinghai-Tibet Plateau represents a unique ecological niche with diverse that harbours several pathogens and numerous uncharacterized pathogens. In this study, we identified characterized novel arenavirus (namely, plateau pika virus, PPV) from pikas (Ochotona curzoniae) on virome analysis. Isolated PPV strains could replicate in mammalian cells. We further...
Type IV interferon (IFN-υ) is a recently discovered cytokine crucial for host defense against viral infections. However, the role and mechanisms of IFN-υ in bacterial infections remain unexplored. This study investigated antibacterial antiviral functions grass carp (
Eight Gram-stain-positive, rod-shaped bacterial strains were isolated from faeces of Tibetan antelopes on the Tibet-Qinghai Plateau China. Genomic sequence analysis showed that belong to genera Actinomyces (strains 299T and 340), Corynebacterium 2184T, 2185, 2183T 2189) Oceanobacillus 160T 143), respectively, with a percentage similarity for 16S rRNA gene under species threshold 98.7 % except 143 arenosus CAU 1183T (98.8 %). The genome sizes (and genomic G+C contents) 3.1 Mb (49.4 %), 2.5...