A5100720456- Aquaculture disease management and microbiota
- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Aquaculture Nutrition and Growth
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Probiotics and Fermented Foods
- Galectins and Cancer Biology
- Plant Disease Resistance and Genetics
- Gut microbiota and health
- Microbial infections and disease research
- Advanced Fluorescence Microscopy Techniques
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Photonic Crystals and Applications
- Macrophage Migration Inhibitory Factor
- Metal-Catalyzed Oxygenation Mechanisms
- Enzyme-mediated dye degradation
- Microbial Metabolism and Applications
- High Entropy Alloys Studies
- Additive Manufacturing Materials and Processes
- Bioinformatics and Genomic Networks
- Liver Disease Diagnosis and Treatment
Hainan University
2025
First Affiliated Hospital of Zhengzhou University
2024-2025
Hong Kong Polytechnic University
2025
Florida State University
2024
Fujian Agriculture and Forestry University
2023-2024
University of Chicago
2016-2024
Guangdong Ocean University
2020-2024
Nanjing Agricultural University
2024
La Sierra University
2024
Henan University of Traditional Chinese Medicine
2024
Scintillating materials that convert ionizing radiation into low-energy photons hold great potential for detection, nondestructive inspection, medical radiography, and space exploration. However, organic scintillators are characterized by low radioluminescence, while bulky inorganic not suitable the development of flexible detectors. Here, high-resolution X-ray imaging using solution-processable lanthanide-based metal-organic frameworks as microscale is demonstrated. Mechanistic studies...
The mechanism and gene markers of head neck squamous cell carcinoma (HNSCC), a common malignant tumor, have not yet been identified. aim this study was to identify the key genes pathways associated with HNSCC further analyze its molecular prognostic significance. In study, expression profile chip data GSE6631 from Gene Expression Omnibus (GEO) included paired tumor normal samples 22 patients; RNAseq tertiary dataset corresponding clinical information Cancer Genome Atlas (TCGA) biological 12...
Arbuscular mycorrhizal fungi are among the most ubiquitous soil plant-symbiotic in terrestrial environments and can alleviate toxic effects of various contaminants on plants. As an essential micronutrient for higher plants, molybdenum (Mo) cause at excess levels. However, arbuscular fungal impacts plant performance Mo accumulation under Mo-contamination still require to be explored. We first studied Claroideoglomus etunicatum BEG168 biomass production a biofuel crop, sweet sorghum, grown...
Materials with tunable emission colors has attracted increasing interest in both fundamental research and applications. As a key member of light-emitting materials family, lanthanide doped upconversion nanoparticles (UCNPs) have been intensively demonstrated to emit light any color upon near-infrared excitation. However, realizing the trichromatic UCNPs fixed composition remains great challenge. Here, without excitation pulsed modulation three different pumping, we report an experimental...
Background . The molecular mechanisms and genetic markers of thyroid cancer are unclear. In this study, we used bioinformatics to screen for key genes pathways associated with development reveal its potential mechanisms. Methods GSE3467, GSE3678, GSE33630, GSE53157 expression profiles downloaded from the Gene Expression Omnibus database (GEO) contained a total 164 tissue samples (64 normal 100 samples). four datasets were integrated analyzed by RobustRankAggreg (RRA) method obtain...
Abstract The N 6 -methyladenosine (m A) modification is deposited to nascent transcripts on chromatin, but its site-specificity mechanism mostly unknown. Here we model the m A deposition pre-mRNA by iM6A ( i ntelligent A), a deep learning method, demonstrating that site-specific methylation primarily determined flanking nucleotide sequences. accurately models (AUROC = 0.99) and uncovers surprisingly cis -elements regulating preferentially reside within 50 nt downstream of sites. enhancers...
The gut–liver axis (GLA) plays an important role in the development of alcohol-induced liver injury. Alcohol consumption is typically associated with folic acid deficiency. However, no clear evidence has confirmed effect supplementation on injury via GLA homeostasis. In this study, male C57BL/6J mice were given 56% (v/v) ethanol and 5.0 mg/kg daily by gavage for 10 weeks to investigate potential protective mechanisms Histopathological biochemical analyses showed that improved lipid...
RNA molecules often play critical roles in assisting the formation of membraneless organelles eukaryotic cells. Yet, little is known about organization RNAs within organelles. Here, using super-resolution imaging and nuclear speckles as a model system, we demonstrate that different sequence domains transcripts exhibit differential spatial distributions speckles. Specifically, image containing region enriched binding motifs serine/arginine-rich (SR) proteins another heterogeneous...
Abstract The pathogenesis of canine pyometra is multifactorial, involving hormonal imbalances, aberrant immune responses, and metabolic dysregulation includes lipid metabolism oxidative stress. This study focuses on stress, revealing the key regulatory role AMPK PLIN2 in pyometra. Bitches with open cervix (n:8) healthy bitches undergoing elective ovariohysterectomy (n:4) were enrolled to study. In experiment one, serum tissue levels Malondialdehyde (MDA) Superoxide Dismutase (SOD) activity...
Marine biological shell waste, as a representative renewable resource, can lead to serious environmental problems and resource waste if effective utilization methods are not developed. Therefore, there is an urgent need for innovative solutions enable the recycling reuse of marine waste. Although previous studies have explored applications shells in chitin extraction animal feed production, this study first reveal possibility obtaining metal resources from shells, which available large...
Reinforcing grain boundaries through solute segregation is a promising strategy to strengthen nanograined metals. However, maintaining strengthening in extremely fine metals poses challenges due size reduction and boundary structural changes from excessive segregation. This study employs hybrid Monte Carlo/Molecular Dynamics simulations investigate the interplay between concentration, structure, deformation mechanism, strength Zr-segregated Cu. Results exhibit significant enhancement by...
The ladder step-inspired uranyl binding protein fiber with twin sites achieves a record-high uranium extraction capacity of 25.6 mg g−1 from seawater in terms adsorption methods.
Malachite green (MG) poses a formidable threat to ecosystems and human health. Laccase emerges as promising candidate for MG degradation, prompting an investigation into the catalytic activity modulation of small laccase (SLAC) from Streptomyces coelicolor, with focus on amino acid position 228. Through saturation mutagenesis, five mutants 50% increase in specific were generated. Characterization revealed notable properties, Km E228F was 8.8% wild type (WT), E288T exhibited 133% kcat...
T-box riboswitches are cis-regulatory RNA elements that regulate the expression of proteins involved in amino acid biosynthesis and transport by binding to specific tRNAs sensing their aminoacylation state. While modular structural recognize different parts a tRNA have been identified, kinetic trajectory describing how these interactions established temporally remains unclear. Using smFRET, we demonstrate binds riboswitch two steps, first anticodon recognition followed 3’ NCCA end, with...
Abstract Thioredoxin reductase 1 (TXNRD1) is one of the major redox regulators in mammalian cells, which has been reported to be involved tumorigenesis. However, its roles and regulatory mechanism underlying progression HCC remains poorly understood. In this study, we demonstrated that TXNRD1 was significantly upregulated tumor tissues correlated with poor survival patients. Functional studies indicated knockdown substantially suppressed cell proliferation metastasis both vitro vivo,...
Phospholipid-hydrolyzing enzymes include members of the phospholipase C (PLC) family that play important roles in regulating plant growth and responding to stress. In present study, a systematic silico analysis wheat PLC gene revealed total 26 genes (TaPLCs). Phylogenetic sequence alignment analyses divided into 2 subfamilies, TaPI-PLC (containing typical X, Y, C2 domains) TaNPC phosphatase domain). TaPLC expression patterns differed among tissues, organs, under abiotic stress conditions....
Abstract Granulation of juice sacs is a physiological disorder, which affects pomelo fruit quality. Here, the transcriptome and ubiquitinome granulated were analyzed in Guanxi pomelo. We found that lignin accumulation was regulated at transcription protein modification levels. In data, we genes biosynthesis pathway antioxidant enzyme system significantly upregulated. However, ubiquitinated enzymes increased abundance but activities decreased after modification, gave rise to reactive oxygen...
Hybrid grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatu) is a popular aquaculture species in recent years. The latest research has found that cottonseed protein concentrate (CPC) been to be an effective alternative fishmeal feed production, but high substitution rates could cause growth inhibition and organism damage hybrid grouper. Compound acidifiers previous studies effectively enhance the digestive performance of fish. Therefore, five isonitrogenous (50% crude protein)...