A5045272535- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- TGF-β signaling in diseases
- Kruppel-like factors research
- Metalloenzymes and iron-sulfur proteins
- Urinary and Genital Oncology Studies
- Cancer Mechanisms and Therapy
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- RNA Research and Splicing
- Proteoglycans and glycosaminoglycans research
- RNA Interference and Gene Delivery
- Redox biology and oxidative stress
- Bladder and Urothelial Cancer Treatments
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2020-2024
Tongji Hospital
2015-2022
Huazhong University of Science and Technology
2015-2022
Peking University
2020
Peking University Cancer Hospital
2020
Creative Commons
2018
National Natural Science Foundation of China
2018
Academia Sinica
1995
Discoidin domain receptor 1 (DDR1) is a member of the tyrosine kinase family, and its ligand collagen. Previous studies demonstrated that DDR1 highly expressed in many tumors. However, role hepatocellular carcinoma (HCC) remains obscure. In this study, we found was upregulated HCC tissues, expression TNM stage II-IV higher than I high associated with poor prognosis. Gene analysis showed target genes were functionally involved metastasis. positively regulated migration invasion cells promoted...
Polo‑like kinase 4 (PLK4) has been identified as an oncogene, which is overexpressed in various types of human cancer; however, its role colorectal cancer (CRC) development remains unknown. The present study demonstrated that PLK4 protein expression was upregulated CRC tissues compared with normal through western blotting. In addition, immunohistochemical analysis 39 specimens further 64.1% (25/39) samples. Increased closely associated enhanced tumor size (P=0.031), lymph node metastasis...
Background and Aims Transforming growth factor beta (TGF‐β) suppresses early stages of tumorigenesis, but contributes to the migration metastasis cancer cells. However, role TGF‐β signaling in invasive prometastatic hepatocellular carcinoma (HCC) is poorly understood. In this study, we investigated roles canonical TGF‐β/mothers against decapentaplegic homolog 3 (SMAD3) identified downstream effectors on HCC metastasis. Approach Results By using vitro trans‐well invasion assays vivo models,...
G-proteins are intracellular partners of G-protein-coupled receptors. As a member the G-protein family, GNB1 has been shown to play pro-cancer role in lung cancer and breast cancer. However, biological function detailed mechanisms hepatocellular carcinoma progression unclear. In this study, we investigated effects its possible mechanism action (HCC). The clinical significance was evaluated large cohort HCC patients, showing that overexpressed compared adjacent normal liver tissues, increased...
Accumulating evidences indicate that non-coding RNAs play crucial roles in the progression of an extensive range carcinomas. This study aimed to investigate action mechanism miR-144-5p and miR-451a cholangiocarcinoma. We found were significantly decreased cholangiocarcinoma patient samples compared adjacent normal bile duct samples. The downregulation these two miRNAs was correlated with a more advanced disease state patients. Overexpression suppressed proliferation, invasion migration cells...
Abstract Thioredoxin reductase 1 (TXNRD1) is one of the major redox regulators in mammalian cells, which has been reported to be involved tumorigenesis. However, its roles and regulatory mechanism underlying progression HCC remains poorly understood. In this study, we demonstrated that TXNRD1 was significantly upregulated tumor tissues correlated with poor survival patients. Functional studies indicated knockdown substantially suppressed cell proliferation metastasis both vitro vivo,...
Abstract Increasing evidence has suggested that liver cancer arises partially from transformed hepatic progenitor cells (HPCs). However, the detailed mechanisms underlying HPC transformation are poorly understood. In this study, we provide linking coexistence of hepatitis B virus X protein (HBx) and transforming growth factor beta 1 (TGF-β1) with miR-199a-3p in malignant HPCs. The examination specimens demonstrated HBx TGF-β1 expression was positively correlated epithelial cell adhesion...
Exonuclease 1 (EXO1), a member of the RAD2 nuclease family, was first described as possessing 5' to 3' activity and structure-specific endonuclease activity.Here, we show that EXO1 is significantly upregulated in HCC tumor tissues high expression correlated with liver cirrhosis.We further demonstrate knockdown decreases proliferation colony forming abilities cells vitro tumorigenicity vivo, well migration invasive capabilities cells.Alternatively, overexpression increases proliferation,...
Uridine is a key metabolite used as substrate for the production of DNA, RNA, and glucose, it mainly synthesized in liver. Currently, not known whether uridine levels are altered tumor microenvironment patients with hepatocellular carcinoma (HCC) can be target therapy. In this study, detection genes associated de novo synthesis, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, dihydroorotase (CAD) (n = 115), dihydroorotate dehydrogenase (DHODH) 115) HCC tissues through tissue...
Abstract Background The Src homology and collagen 4 (SHC4) is an important intracellular adaptor protein that has been shown to play a pro-cancer role in melanoma glioma. However, the biological function detailed mechanisms of SHC4 hepatocellular carcinoma progression are unclear. This study aimed evaluate potential prognostic treatment value patients with HCC. Methods expression status HCC tissues were investigated by immunohistochemistry western blotting. Clinical significance was...
Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and more effective prognostic markers are needed. Lactic acid has been proved to be an important metabolite involved in cancer development, metastasis, the tumor microenvironment, affecting prognosis of patients. The role lactic metabolism regulators (LAMRs) HCC still unclear. In this study, we analyzed status LAMRs, gene list containing lactate from Molecular Signatures database, consensus clustering was performed based on...
Objective: Immune checkpoint inhibitors (ICIs) have recently demonstrated promising performance in improving the prognosis of urological cancer patients. The goal this meta-analysis was to determine impact PPI use on clinical outcomes patients receiving ICI therapy. Methods: Before 6 May 2022, eligible literature searched using PubMed, EMBASE, Cochrane Library, and Google Scholar. were overall survival (OS), progression-free (PFS), objective response rate (ORR). Results: A total six articles...
Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In present study, plasma profiles 3 HCC HBV 1 healthy volunteer were examined by microarray analysis, order to identify relevant miRNAs involved pathogenesis infection. The results indicated 26 exhibited a ≥20-fold increase or...
Portal vein thrombosis is defined as any that develops in the portal system. It considered a very rare and extremely lethal complication of hepatopancreatobiliary surgery.Acute after hepatectomy patients with hepatolithiasisis rare. Acute dangerous hepatectomy. easy to ignore symptom acute thrombosis. Once appropriate time treatment past, it would lead patients' death.Acute patient hepatolithiasis INTERVENTIONS:: We consider anticoagulation therapy percutaneous transhepatic puncture...
Hepatocellular carcinoma (HCC) is a widespread and impactful cancer which has pertinent implications worldwide. Although most cases of HCC are typically diagnosed in individuals aged ≥60 years, there been notable rise the occurrence among younger patients. However, scarcity precise prognostic models available for predicting outcomes these A retrospective analysis was conducted to investigate early-onset hepatocellular (EO-LIHC) using data from Surveillance, Epidemiology, End Results (SEER)...
Objective: To study the clinicopathological features and PD-L1 expression of microsatellite instability-high (MSI-H) gastric cancer. Methods: The data 2 472 patients who had undergone radical surgical resection been performed immunohistochemical staining four major mismatch repair (MMR) proteins (MLH1, PMS2, MSH2 MSH6) from March 2014 to December 2018 at Peking University Cancer Hospital were collected. One hundred seventy-one showed repair-deficient (dMMR), instability these detected with...