Abstract Objective Gut mycobiota plays a crucial role in benign liver diseases; however, its correlation with hepatocellular carcinoma (HCC) remains elusive. This study aimed to elucidate fungal differences patients HCC-associated cirrhosis compared cirrhotic without HCC and healthy controls. Methods The 72 fecal samples from 34 patients, 20 18 controls were collected analyzed using ITS2 rDNA sequencing. Results Our results revealed the presence of intestinal dysbiosis significant enrichment...

Background: After glucagon and insulin, amylin is the third most significant active islet hormone. Amylin insulin act synergistically to suppress postprandial blood glucose levels. Research has shown that plays a vital role in growth progression of cancer; however, relationship between gastric cancer (GC) unclear.

Intrahepatic cholangiocarcinoma (ICC) is a silent liver malignancy with an increasing incidence. Gut mycobiota plays crucial role in benign diseases; however, its correlation ICC remains elusive. This study aimed to elucidate fungal differences patients compared healthy controls. The 40 fecal samples from 23 and 17 controls were collected analyzed using ITS2 rDNA sequencing. Obtaining the OTUs combining effective grouping, we carried out biodiversity composition of fungi, as well FUNGuild...

Objective To understand the relationship between steroid hormones synthesized by gonads and colorectal cancer as well its tumor microenvironment, in expectation of providing new ideas order to detect treat cancer. Methods Through reviewing relevant literature at home abroad, we summarized that androgens promote growth cancer, estrogens progesterone help prevent bowel from developing; these three also have a role cellular other non-cellular components microenvironment Conclusion The current...

Prolyl 3-hydroxylase 1 (P3H1) is essential for human collagen synthesis. Here, we investigated its relevance to multiple cancers, especially hepatocellular carcinoma (LIHC). We estimated the relationship of P3H1 with 33 cancers using publicly available databases. And immunohistochemistry was utilized verify expression in liver, gastric, colon, pancreatic, and rectal cancer. Then, attenuated BEL-7402 HLF cells by lentivirus technology assessed effect on cell proliferation, migration,...

Abstract DBF4 zinc finger (DBF4) is a critical component involved in DNA replication and cell proliferation. It acts as positive regulator of the division cycle 7 kinase. In this study, our investigation encompassed impact on hepatocellular carcinoma (HCC) progression delved into potential mechanisms. We utilized open-access databases like TCGA GEO to analyze association between 33 different tumor types. also conducted immunohistochemistry experiments validate expression HCC, STAD, COAD,...

Objective: Immune checkpoint inhibitors (ICIs) have recently demonstrated promising performance in improving the prognosis of urological cancer patients. The goal this meta-analysis was to determine impact PPI use on clinical outcomes patients receiving ICI therapy. Methods: Before 6 May 2022, eligible literature searched using PubMed, EMBASE, Cochrane Library, and Google Scholar. were overall survival (OS), progression-free (PFS), objective response rate (ORR). Results: A total six articles...

SummaryObjectiveThe impact of sarcopenia on the efficacy immune checkpoint inhibitors (ICI) in gastrointestinal cancer (GIC) patients remains uncertain clinical practice. Hence, this study aims to investigate potential correlation between and outcomes GIC treated with ICIs.MethodsTo gather pertinent studies, a systematic literature search was implemented across multiple databases, including PubMed, Embase, Cochrane Library, Google Scholar. The primary interest were overall survival (OS)...

ATP citrate lyase (ACLY) and acyl-CoA short-chain synthetases 2 (ACSS2) are key enzymes in lipid metabolism. We explored the role of ACLY gastric cancer (GC) effect ACSS2 compensation on GC growth. used immunohistochemistry to verify expression level GC, shRNA stably knock down cells. The levels metabolizing were verified by qPCR WB, targeted lipidomics quantification metabolism-related indicators helped us understand changes Finally, subcutaneous graft tumors validate our findings from...

Hepatocellular carcinoma (HCC) is a widespread and impactful cancer which has pertinent implications worldwide. Although most cases of HCC are typically diagnosed in individuals aged ≥60 years, there been notable rise the occurrence among younger patients. However, scarcity precise prognostic models available for predicting outcomes these A retrospective analysis was conducted to investigate early-onset hepatocellular (EO-LIHC) using data from Surveillance, Epidemiology, End Results (SEER)...

Abstract Background: This study ought to further explore the anti-tumor effects of Sophoridine on gastric cancer cells. Methods: Cell viability assay (CCK-8 assay) was used measure IC50 values gastirc AGS and SGC7901 cell lines normal epithelial line GES-1. EdU colony formation were performed confirm cytotoxic effect The apoptotic cells measured by Flow cytometry. Transwell evaluate migration invasion protein expression detected via Western blot. Results: We demonstrated that exerts potent...

Abstract Background: An increasing number of studies have focused on the association between leptin, adiponectin levels and risk as well prognosis hepatocellular carcinoma. However, reported results are conflicting. Methods: A meta-analysis was performed to assess correlation carcinoma (CRD42020195882). Through June 14, 2020, PubMed, Cochrane Library EMBASE databases were searched, including references qualifying articles. Titles, abstracts, main texts reviewed by at least 2 independent...