A5100462192- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Liver physiology and pathology
- Wnt/β-catenin signaling in development and cancer
- Mitochondrial Function and Pathology
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Zhangzhou Normal University
2023-2024
West China Hospital of Sichuan University
2021-2024
Ministry of Education of the People's Republic of China
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Sichuan University
2021-2024
Nantong University
2020-2023
Yancheng First People's Hospital
2020-2023
Fujian University of Traditional Chinese Medicine
2020-2022
Background and Aims Because of a paucity effective treatment options, metastasis is still major cause for HCC-associated mortality. The molecular mechanism inflammation-induced HCC open study. Here, we characterized the function solute carrier family 7 member 11 (SLC7A11) in inflammation-related probed therapy strategies this subpopulation patients. Approach Results Elevated expression SLC7A11 was positively correlated with poor tumor differentiation, higher tumor-nodule-metastasis stage,...
Abstract The durable response rate to immune checkpoint blockade such as anti-programmed cell death-1 (PD-1) antibody remains relatively low in hepatocellular carcinoma (HCC), mainly depending on an immunosuppressive microenvironment with limited number of CD8 + T cells, especially stem-like tumor tissues. Here we develop engineered microparticles (MPs) derived from alpha-fetoprotein (AFP)-overexpressing macrophages load resiquimod (R848@M2pep-MPs AFP ) for enhanced anti-PD-1 therapy HCC....
RNA-binding protein (RBP) dysregulation is functionally linked to several human diseases, including neurological disorders, cardiovascular disease, and cancer. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RBPs involved in nucleic acid metabolism. A growing body studies has shown that the dysregulated hnRNPs play important roles tumorigenesis. Here, we found heterogeneous ribonucleoprotein C (C1/C2) (HNRNPC) had good performance distinguishing between...
RNA modifications play a pivotal role in regulating cellular biology by exerting influence over distribution features and molecular functions at the post-transcriptional level.Among these modifications, N7-methylguanosine (m7G) stands out as one of most prevalent.Over recent years, significant attention has been directed towards understanding implications m7G modification.This modification is present diverse molecules, including transfer RNAs, messenger ribosomal other noncoding RNAs.Its...
Abstract Tumor angiogenesis plays an essential role in carcinogenesis, cancer progression, and metastasis. Some studies indicate that lipoxins, endogenous anti-inflammatory lipid mediators, might be involved tumor angiogenesis; however, the governing mechanisms are still unknown. In present study, we examined effects of exogenous lipoxin A4 (LXA4) mouse hepatocarcinoma cell line (H22) H22-bearing mice model. It was found H22 cells, LXA4 inhibited production vascular endothelial growth factor...
Abstract Metastasis is the predominant reason for high mortality of hepatocellular carcinoma (HCC) patients. It critical to explore molecular mechanism underlying HCC metastasis. Here, we reported that transcription factor One Cut homeobox 2 (ONECUT2) functioned as an oncogene facilitate Elevated ONECUT2 expression was positively correlated with increased tumor number, encapsulation loss, microvascular invasion, poor differentiation, and advanced TNM stage. Mechanistically, directly bound...
As the most important RNA epigenetic regulation in eukaryotic cells, N6-metheyladenosine (m6A) modification has been demonstrated to play significant roles cancer progression. However, this long intergenic non-coding RNAs (lincRNAs) and corresponding functions remain elusive. Here, we showed a lincRNA LINC02551 was downregulated by AlkB Homolog 5 (ALKBH5) overexpression m6A-dependent manner hepatocellular carcinoma (HCC). Functionally, required for growth metastasis of HCC. Mechanistically,...
Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap 'n' Collar basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates epigenetic modifications, heme homeostasis, oxidative stress. Additionally, involved immune system development. More importantly, highly plays a key role numerous malignant tumors, affecting cellular metabolism, tumor invasion metastasis, proliferation, different cell death pathways, drug...
The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation SOX members closely associated tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research investigate mechanisms functions...
Proteases can regulate many aspects of tumor development as their actions, which include degradation the extracellular matrix, proteolytic processing chemokines and activation other enzymes, influence several key tumorigenic processes. Members one protease class, cysteine cathepsins, have received increasing recognition for involvement in cancer development, numerous clinical studies reported correlations between elevated cathepsin levels malignant progression. This is also case H, a member...
Metastasis is a major determinant of death in patients with hepatocellular carcinoma (HCC). Dissecting key molecular mediators that promote this malignant feature may help yield novel therapeutic insights. Here, we investigated the role E-twenty-six transformation-specific variant 1 (ETV1), member (ETS) family, HCC metastasis. METHODS: The clinical significance ETV1 and its target genes two independent cohorts who underwent curative resection were assessed by Kaplan-Meier analysis...
Abstract Background Aberrant expressions of long noncoding RNAs (lncRNAs) have been demonstrated to be related the progress HCC. The mechanisms that SNHG14 has participated in development HCC are obscure. Methods Quantitative real-time PCR (qRT-PCR) was used measure lncRNA, microRNA and mRNA expression level. Cell migration, invasion proliferation ability were evaluated by transwell CCK8 assays. ceRNA regulatory mechanism RNA immunoprecipitation (RIP) dual luciferase reporter assay....
Abstract Background Tigecycline, a first-in-class broad-spectrum glycylcycline antibiotic, has in vitro activity against bacteria commonly encountered complicated intra-abdominal infections (cIAIs), including aerobic and facultative Gram-positive Gram-negative anaerobic bacteria. In the current trial, tigecycline was evaluated for safety efficacy vs. imipenem/cilastatin hospitalized Chinese patients with cIAIs. Methods this phase 3, multicenter, open-label study, were randomly assigned to...
ABSTRACTS This research aimed to explore effects of SIX1 and DACH1 on hepatocellular carcinoma (HCC) cell proliferation, apoptosis cycle. Fifty paired tissues were screened for differentially expressed genes. expressions subjected qRT-PCR western blot in tumor cells. The knockdown efficiency siRNAs transfection cDNAs validated by as well. Then colony formation assay flow cytometry applied observe cycle changes. Immunofluorescence co-localization immunoprecipitation used analyze the...
The aim of this study was to investigate the effect role and mechanism miR-30b-3p on ovarian cancer cells biological function. expression detected in cell lines normal epithelial line by qRT-PCR. Mir-30b-3p mimic transfected into OVCAR3 cells. Cell-counting kit-8 (CCK-8) assay conducted explore mir-30b-3p cells' proliferation. Cell cycle apoptosis were Flow cytometry. invasion ability Transwell test. regulation putative target verified double luciferase reporter assays Western blot. We found...