A5106265104- Skin Protection and Aging
- Bladder and Urothelial Cancer Treatments
- Neuropeptides and Animal Physiology
- Genital Health and Disease
- Urological Disorders and Treatments
- Acne and Rosacea Treatments and Effects
- Cancer Cells and Metastasis
- Dermatology and Skin Diseases
- Bioactive Compounds and Antitumor Agents
- Adipose Tissue and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Sexual function and dysfunction studies
- Nonmelanoma Skin Cancer Studies
- Urologic and reproductive health conditions
- Receptor Mechanisms and Signaling
- Cell Adhesion Molecules Research
- Healthcare and Venom Research
- Immune Cell Function and Interaction
- Advanced Glycation End Products research
- Wound Healing and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- Plant Pathogenic Bacteria Studies
- Ion Channels and Receptors
- Metabolism, Diabetes, and Cancer
University of South China
2024-2025
Southern Medical University
2012-2025
Affiliated Hospital of Jiangsu University
2022-2025
Jiangsu University
2022-2025
Soochow University
2023-2024
Nanchang University
2024
Nanjing Second Hospital
2024
Central China Normal University
2024
Minzu University of China
2023
Wuhan University
2009-2023
Aim: The aim of this study was to assess the efficacy, safety, and morbidity minimally invasive tract in percutaneous nephrolithotomy (Mini-PCNL) for renal stones comparison with standard PCNL. Patients Methods: In a randomized trial, 69 patients (72 units) undergoing Mini-PCNL (group 1) from May 2004 December 2007 were compared similar group 111 (115 PCNL 2). who needed more than one or had simultaneously undergone two techniques on same unit excluded group. Chi-square test performed...
Cinobufacini is a well-known Chinese medicine extracted from Venenum Bufonis, also called Chan Su. It has been used clinically for various cancers, including colon cancer. However, the function of on cancer invasion and metastasis, its underlying molecular mechanism, still not clear. In this study, we investigated mechanism metastasis both in vitro vivo studies. Human cells were cultured. CCK assay was to detect effect proliferation. The migration abilities observed by transwell assays,...
Abstract Bedaquiline fumarate tablets are a novel oral antimycobacterial drug. This study assessed the bioequivalence of generic bedaquiline tablet compared to reference under fasting (n = 44) and fed 24) conditions. Conducted as single‐center, randomized, open‐label, 2‐sequence, crossover trial, 68 participants were randomly assigned receive 100‐mg dose either test or tablet, with 42‐day washout period between doses. Blood samples collected at prespecified time points from 0 hour (before...
Cognitive impairment induced by chronic methamphetamine (METH) exposure exhibits similarities to neurodegenerative disorders and is associated with blood-brain barrier (BBB) dysfunction. However, the potential involvement of β-catenin in maintaining BBB integrity during METH remains unexplored. In this study, Y-maze novel object recognition tests were conducted assess cognitive mice exposed chronically for 2 4 weeks. Gd-DTPA Evans blue leakage revealed disruption hippocampus, while weeks...
Manganese monoxide (MnO), a versatile manganese oxide, is highly regarded for its potential to address heavy metal and radioactive contamination effectively. In this study, we investigated the adsorption mechanism of strontium nitrate solution on MnO crystal surfaces using molecular dynamics simulations. We examined effects diffusion ions water molecules three distinct surfaces. The results revealed significant differences in capacities Sr2+, NO3−, H2O radial distribution function (RDF),...
Abstract Glycoprotein Ibα (GPIbα), the ligand-binding subunit of platelet GPIb-IX complex, interacts with von Willebrand factor (VWF) exposed at injured vessel wall, initiating adhesion, activation, hemostasis, and thrombus formation. The cytoplasmic tail GPIbα 14-3-3ζ, regulating VWF-GPIbα–elicited signal transduction VWF binding function GPIbα. However, we unexpectedly found that GPIbα–14-3-3ζ association, beyond VWF-dependent function, is essential for general activation. We myristoylated...
Methamphetamine (METH) is a highly abused substance on global scale and has the capacity to elicit toxicity within central nervous system. The neurotoxicity induced by METH encompasses neuronal degeneration cellular demise substantia nigra-striatum hippocampus. Caffeic acid phenethyl ester (CAPE), constituent of propolis, diminutive compound that demonstrates antioxidative anti-inflammatory characteristics. Numerous investigations have demonstrated safeguarding effects CAPE in various...
Topical drugs for mild to moderate acne include adapalene (ADA) and benzoyl peroxide(BPO). Supramolecular salicylic acid (SSA), a modified SA preparation, is considered as new effective therapeutic scheme.To compare the safety efficacy of 2% supramolecular (2% SSA) with 0.01% plus 5% peroxide (5%BPO +0.1%ADA) treatment facial acne.This was an open-label, split face, randomized single-centre clinical trial. Subjects were enrolled. Two percent SSA cream randomly applied on one side face while...
Achaete-scute-like 2 (ASCL2) is a transcription factor containing basic helix-loop-helix (bHLH) domain and downstream target of Wnt signaling in intestinal stem cells. Bufalin the primary active ingredient Chan Su, traditional Chinese medicine obtained from skin parotid venom glands toads. The purpose this study was to research anti-invasion anti-metastasis activity bufalin gastric cancer identify potential mechanism. inhibited cell invasion metastasis, suppressed colony formation, growth...
Endomorphins were recently identified as endogenous ligands with high selectivity for mu opioid receptors. We have characterized the ability of endomorphins to bind and functionally activate cloned human receptor. Both endomorphin‐1 endomorphin‐2 exhibited binding receptor over delta kappa agonists inhibited forskolin‐stimulated increase cAMP in a dose‐dependent fashion. When was coexpressed Xenopus oocytes G protein‐activated K + channels, application either endomorphin activated an inward...
The application of adipose derived stem cells (ADSCs) in skin repair has attracted much attention nowadays. Epidermal growth factor (EGF) participates the progress proliferation, differentiation and so forth. We aimed to explore role EGF invasion, migration transdifferentiation into epidermal cell phenotypes ADSCs.ADSCs were extracted from tissues patient. Immunophenotyping was determined by flow cytometry. Overexpressed or siEGF transfected lentiviruses. enzyme linked immunosorbent assay...
The formation and regulation mechanisms of pore structures in porous geopolymers (PGs) remain qualitatively unclear, posing significant challenges to their practical application performance optimization. In this study, PGs were synthesized utilizing metakaolin as the primary raw material hydrogen peroxide foaming agent. Three distinct surfactants—sodium dodecyl sulfate, hydroxypropyl methylcellulose, cetyltrimethylammonium bromide—were incorporated fabricate three unique categories PGs....
Oncostatin M (OSM) is an inflammatory cytokine which has been found to be expressed at sites of atherosclerotic lesions. We sought investigate whether serum OSM levels are associated with coronary stenosis in patients artery disease (CAD).A total 117 CAD and 35 without who underwent angiography were enrolled this study. Serum measured by enzyme-linked immunosorbent assay. The severity was assessed the number diseased vessels score.Serum significantly elevated compared those CAD. A stepwise...
Abstract Bladder cancer is the second most prevalent urological malignancy. It's a big contributor to cancer-related deaths throughout globe. Researchers discovered that hedgehog signaling (HhS) pathway contributed onset and spread of many different kinds cancer. Nevertheless, present understanding function HhS in bladder molecular landscape incomplete. Raw data were gotten from IMvigor210, Gene Expression Omnibus, The Cancer Genome Atlas databases. Bioinformatics was used examine score each...
Objective: The aim of this investigation was to explore the correlation between levels tumor-infiltrating CD8+ and CD4+ T cells quantitative pharmacokinetic parameters dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with advanced gastric cancer. Methods: We retrospectively analyzed data 103 histopathologically confirmed cancer (AGC). Three parameters, Kep, Ktrans, Ve, their radiomics characteristics were obtained by Omni Kinetics software. Immunohistochemical...