A5017393230- RNA modifications and cancer
- 14-3-3 protein interactions
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
Soochow University
2024
Hebei Medical University
2022
Second Hospital of Hebei Medical University
2022
Abstract Glycoprotein Ibα (GPIbα), the ligand-binding subunit of platelet GPIb-IX complex, interacts with von Willebrand factor (VWF) exposed at injured vessel wall, initiating adhesion, activation, hemostasis, and thrombus formation. The cytoplasmic tail GPIbα 14-3-3ζ, regulating VWF-GPIbα–elicited signal transduction VWF binding function GPIbα. However, we unexpectedly found that GPIbα–14-3-3ζ association, beyond VWF-dependent function, is essential for general activation. We myristoylated...
Abstract Objective LINC00114 could promote the development of colorectal cancer, but its mechanism has been rarely discussed in esophageal cancer (EC). Herein, we explored molecular via mediating enhancer zeste homolog 2/deleted liver 1 (EZH2/DLC1) axis EC. Methods LINC00114, EZH2 and DLC1 expression EC tissues cells were tested. altered through transfection with different constructs, cell proliferation, migration, invasion, apoptosis glycolysis subsequently observed. The interaction between...