A5100767688- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- Healthcare Education and Workforce Issues
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Plant Micronutrient Interactions and Effects
- Nanocluster Synthesis and Applications
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Hypoxia, and Metabolism
- Magnesium in Health and Disease
- Reproductive System and Pregnancy
Soochow University
2006-2025
First Affiliated Hospital of Soochow University
2006-2025
Brigham and Women's Hospital
2006
Harvard University
2006
Northwestern University
2006
Inactivation of p53 by mutations commonly occurs in human cancer. The mutated proteins may escape proteolytic degradation and exhibit high expression tumors acquire gain-of-function activity that promotes tumor progression chemo-resistance. Therefore, selectively targeting the mutants serve as a promising therapeutic strategy for cancer prevention treatment. In this study, we identified cabozantinib, multikinase inhibitor currently used clinical treatment several types cancer, selective...
Cervical cancer is a leading cause of cancer-related deaths, with cervical squamous cell carcinoma (CSCC) accounting for majority cases. Circular RNAs (circRNAs) have been repeatedly suggested as crucial effectors in modulating development multiple malignancies. The expression circ_0002762 was predicted to be high CSCC tissues GEO dataset, but the functional role and underlying regulatory mechanism unclear. By series assays assays, supported by bioinformatics analysis, reverse transcription...
The aim of this study was to investigate the effect role and mechanism miR-30b-3p on ovarian cancer cells biological function. expression detected in cell lines normal epithelial line by qRT-PCR. Mir-30b-3p mimic transfected into OVCAR3 cells. Cell-counting kit-8 (CCK-8) assay conducted explore mir-30b-3p cells' proliferation. Cell cycle apoptosis were Flow cytometry. invasion ability Transwell test. regulation putative target verified double luciferase reporter assays Western blot. We found...
Abstract Ovarian cancer (OC) is a malignant tumor with high mortality in women. Although patients initially respond to paclitaxel chemotherapy following surgery, most will relapse after 12–24 months and gradually die from resistance. In OC, cells become resistant under hypoxic environment. The miR-27a has been identified as an oncogenic molecular ovarian cancer, prostate liver etc. addition, the involved hypoxia-induced chemoresistance various cancers. However, role of OC resistance remains...
Cervical cancer is the fourth most common cause of cancer-associated mortality in women worldwide. Previous studies have reported that microRNAs (miRNAs) are involved multiple biological aspects progression by regulating gene expression. Here, we investigated role microRNA-708 (miR-708) cervical cancer.The expression levels miR-708 tissues and paired-normal were tested quantitative polymerase chain reaction (qPCR). The interaction between Timeless was identified bioinformatics method,...
The aim of the present study was to identify differentially expressed microRNAs (miRs) in cervical carcinoma (CC) tissues and cells explore function miR‑302c‑3p miR‑520a‑3p proliferation CC cells. Potential dysregulated miRNAs tumour‑adjacent were detected. Reverse transcription‑quantitative PCR (RT‑qPCR) performed determine expression miR‑302c‑3p, CXCL8 cell lines. target genes predicted using miRTarBase verified by luciferase reporter assays. RT‑qPCR western blotting measure C‑X‑C motif...
Oxygen and glucose deprivation (OGD)-re-oxygenation (OGDR) stimulation to the human endometrial cells mimics ischemia-reperfusion injury.Cyclophilin D (CypD)-dependent programmed necrosis pathway mediates OGDRinduced cytotoxicity cells.We here identified a novel CypD-targeting miRNA, microRNA-1203 (miR-1203).In T-HESC primary cells, ectopic overexpression of miR-1203, using lentiviral construct, potently downregulated CypD 3'-untranslated region (3'-UTR) activity its expression.Both were...
Cervical cancer (CC) remains a major cause of cancer-related mortality among women globally. Long noncoding RNAs (lncRNAs) play crucial regulatory roles in various cancers, including CC. This study investigates the function novel lncRNA, USP30 antisense RNA 1 (USP30-AS1), CC tumorigenesis. We analyzed USP30-AS1 expression using RT-qPCR and conducted vitro loss-of-function assays, as well vivo to evaluate effects silencing on cell growth migration. Additional mechanistic experiments,...
Here, we reported a simple method for recognizing CA125 overexpressed serum samples using array‐based fluorescent gold nanoclusters (AuNCs). The sensing array was fabricated by the combination of various aptamer functionalized AuNCs. fluorescence different aptamer‐capped AuNCs quenched to extent in presence CA125. By comprehensive analysis these changes, unique patterns were formed when samples. This strategy is successfully used discriminating human samples, which have great importance...