A5102720780- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Meningioma and schwannoma management
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- FOXO transcription factor regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Protein Kinase Regulation and GTPase Signaling
- Plant Genetic and Mutation Studies
- Helicobacter pylori-related gastroenterology studies
- BRCA gene mutations in cancer
Soochow University
2018-2024
First Affiliated Hospital of Soochow University
2018-2024
Suzhou Research Institute
2019
Soochow University
2019
Abstract Unsatisfied cytoreductive surgery predicts worse clinical outcomes. Previous studies have found that cyclophosphamide (CTX) is a rhythmic immune modulator can target suppressive regulatory cells and meanwhile enhance effector cells. Here, therapeutic scaffold engineered based on fibrin hydrogel to codeliver CTX anti‐PD‐L1 antibody (aPDL1) for the prevention of cancer recurrence postsurgery. It demonstrated sequential release aPDL1 from lead selective depletion T (Treg) in residual...
Salt-inducible kinase 2 (SIK2; also known as serine/threonine-protein SIK2) is overexpressed in several cancers and has been implicated cancer progression. However, the mechanisms by which SIK2 regulates cell motility, migration metastasis ovarian have not fully discovered. Here, we identify that promotes vitro vivo. Mechanistically, regulated motility myosin light chain kinase, smooth muscle (MYLK)-meditated phosphorylation of (MYL2). directly phosphorylated MYLK at Ser343 activated its...
Radiotherapy (RT) has been used clinically to overcome cancer in recent decades.
Timeless is a regulator of molecular clockwork in Drosophila and related to cancer development mammals. This study aimed investigate the effect on cell proliferation cisplatin sensitivity cervical cancer. expression was determined by bioinformatics analysis, immunohistochemistry, quantitative polymerase chain reaction (qPCR). Chromatin immunoprecipitation assays reporter gene were applied determine transcriptional factor contributing upregulation. The effects depletion through vitro vivo...
Maternal embryo leucine zipper kinase (MELK) is highly expressed in a variety of malignant tumors and involved cell cycle regulation, proliferation, apoptosis, tumor formation etc However, the biological effects MELK cervical cancer are still uninvestigated. This study aimed to explore expression cancer, as well its on DNA damage repair line vitro provide novel ideas for further improving clinical efficacy cancer. Immunohistochemistry, Western blot, RT-qPCR, CCK8, immunofluorescence...
Cervical cancer is the fourth most common cause of cancer-associated mortality in women worldwide. Previous studies have reported that microRNAs (miRNAs) are involved multiple biological aspects progression by regulating gene expression. Here, we investigated role microRNA-708 (miR-708) cervical cancer.The expression levels miR-708 tissues and paired-normal were tested quantitative polymerase chain reaction (qPCR). The interaction between Timeless was identified bioinformatics method,...
Background Genome instability plays a crucial role in promoting tumor development. Germline mutations genes responsible for DNA repair are often associated with familial cancer syndromes. A noticeable exception is the CHEK1 gene. Despite its well-established homologous recombination, germline rarely reported. Case presentation In this report, we present patient diagnosed ovarian clear cell carcinoma who has family history of cancer. Her relatives include grandfather esophageal cancer, father...
Radiotherapy (RT) has been used clinically to overcome cancer in recent decades. However, the abnormal tumor microenvironment (TME) featured with hypoxia, acidosis, and dense extracellular matrix is found be related resistance of tumors RT. Herein, intelligent bovine serum albumin (BSA)-coated Bi2S3 MnO2 (Bi2S3-MnO2) nanocomposites synthesized by biomineralization are capable modulating hypoxic TME effectively enhance efficacy After intravenous injection, BSA-Bi2S3-MnO2 show efficient...