A5061000731- FOXO transcription factor regulation
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Migraine and Headache Studies
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Trigeminal Neuralgia and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- MicroRNA in disease regulation
- Neurosurgical Procedures and Complications
- Cancer Mechanisms and Therapy
- Psychosomatic Disorders and Their Treatments
- Immune cells in cancer
- RNA Research and Splicing
- Fibroblast Growth Factor Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Stress Responses and Cortisol
- Pluripotent Stem Cells Research
- Protein Degradation and Inhibitors
- PARP inhibition in cancer therapy
- Neurogenesis and neuroplasticity mechanisms
- Chemokine receptors and signaling
- Cell death mechanisms and regulation
- Growth Hormone and Insulin-like Growth Factors
- Radiomics and Machine Learning in Medical Imaging
East China University of Technology
2024
Tongji Hospital
2019-2023
Huazhong University of Science and Technology
2019-2023
China Medical University
2018-2022
Shanghai Medical College of Fudan University
2016
Abstract UHRF1 is an important epigenetic regulator for maintenance DNA methylation. recognizes hemi-methylated (hm-DNA) and trimethylation of histone H3K9 (H3K9me3), but the regulatory mechanism remains unknown. Here we show that adopts a closed conformation, in which C-terminal region (Spacer) binds to tandem Tudor domain (TTD) inhibits H3K9me3 recognition, whereas SET-and-RING-associated (SRA) plant homeodomain (PHD) H3R2 recognition. Hm-DNA impairs intramolecular interactions promotes...
RNA-binding protein (RBP) dysregulation is functionally linked to several human diseases, including neurological disorders, cardiovascular disease, and cancer. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RBPs involved in nucleic acid metabolism. A growing body studies has shown that the dysregulated hnRNPs play important roles tumorigenesis. Here, we found heterogeneous ribonucleoprotein C (C1/C2) (HNRNPC) had good performance distinguishing between...
Forkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. family protein lays pivotal role in metabolism. ROS involved tumor progression associated with expression lots transcription factors. We next explored mechanism underlying FOXC1 modulating metabolism hemostasis HCC.We used amino acids arrays to verify which FOXC1-induced HCC. The kits were detect levels cells over-expression or down-expression FOXC1. After identified downstream...
Metastasis is a major determinant of death in patients with hepatocellular carcinoma (HCC). Dissecting key molecular mediators that promote this malignant feature may help yield novel therapeutic insights. Here, we investigated the role E-twenty-six transformation-specific variant 1 (ETV1), member (ETS) family, HCC metastasis. METHODS: The clinical significance ETV1 and its target genes two independent cohorts who underwent curative resection were assessed by Kaplan-Meier analysis...
Abstract Objectives Induction of deactivation and apoptosis hepatic stellate cells (HSCs) are principal therapeutic strategies for liver fibrosis. Krüppel‐like factor 14 (KLF14) regulates various biological processes, however, roles, mechanisms implications KLF14 in fibrosis unknown. Materials Methods expression was detected human, rat mouse fibrotic models, its effects on HSCs were assessed. Chromatin immunoprecipitation assays utilized to investigate the binding peroxisome...
Coiled‐coil domain containing 85 B (CCDC85B) is involved in diverse biological processes; however, its expression patterns and functions human cancers are yet unknown. The present study demonstrated that the of CCDC85B cytoplasm non‐small cell lung cancer (NSCLC) tumor cells was significantly higher compared to adjacent normal tissues ( P < 0.05). Furthermore, correlated with advanced TNM stage = 0.004) positive regional lymph node metastasis 0.009) NSCLC. In addition, A549 H1299 lines,...
To investigate the efficacy and safety of four interventions spontaneous intracerebral hemorrhage simultaneously.PubMed, EmBase, Web Science, Cochrane Central Register Controlled Trials were searched for randomized controlled trials (RCTs) investigating endoscopic surgery (ES), minimally invasive puncture (MIPS), conventional craniotomy (CC), and/or conservative medical treatment (CMT). Good functional outcome, death, recurrence rates evaluated by a network meta-analysis.20 RCTs with 3603...
Background/aim: Pulmonary microvascular endothelial cells (PMVECs) play a pivotal role in the process of acute lung injury (ALI), which can be induced by lipopolysaccharide (LPS). Numerous reports have indicated that both miR-33 and RIP140 are involved inflammatory response macrophages. In this study, we sought to investigate whether participate ALI LPS.Materials methods: First, isolated identified PMVECs from BALB/c mice. Subsequently, mice were treated with PBS, LPS, or pyrrolidine...
Necroptosis, a type of programmed cell death, has recently been extensively studied as an important pathway regulating tumor development, metastasis, and immunity. However, the expression patterns necroptosis-related genes (NRGs) in colorectal cancer (CRC) their potential roles microenvironment (TME) have not elucidated. We explored NRGs 1247 samples from genetics transcriptional perspective. Based on consensus clustering algorithm, we identified NRG molecular subtypes gene subtypes,...
Zinc finger protein 668 (ZNF668) is a recently discovered and its expression levels, as well involvement in the invasion metastasis of non-small cell lung cancer (NSCLC), are largely unknown. In present study, immunohistochemical analysis demonstrated that ZNF668 was decreased tumors (51/167, 30.5%) compared with adjacent normal tissues (43/62, 69.4%; P<0.001). Subsequent statistical revealed negatively associated increased tumor-node-metastasis stage (P=0.019) lymph node (P=0.002)....
Abstract Background: Migraine is one of the most common neurological disorders that leads to disabilities. However, conventional drug therapy for migraine unsatisfactory. Therefore, this meta-analysis aimed evaluate efficacy and safety calcitonin-gene-related peptide binding monoclonal antibody (CGRP mAb) preventive treatment episodic migraine, provide high-quality clinical evidence therapy. Methods: A systematic electronic database search was conducted identify potentially relevant studies....
Astrocytes are promising source cells to replace neurons lost disease owing a shared lineage and capacities for dedifferentiation proliferation under pathological conditions. Reprogramming of astrocytes has been achieved by transcription factor modulation, but reprogramming in vitro or vivo using small‐molecule drugs may have several advantages clinical application. For instance, small molecules can be extensively characterized efficacy, toxicity, tumorigenicity vitro; induce rapid...
Abstract Background: Forkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. family protein lays pivotal role in metabolism. ROS involved tumor progression associated with expression lots transcription factors. We next explored mechanism underlying FOXC1 modulating metabolism hemostasis HCC. Methods: used amino acids arrays to verify which FOXC1-induced The kits were detect levels cells over-expression or down-expression FOXC1. After...
Abstract The difficulty of early diagnosis, high tumor heterogeneity, and recurrence metastasis rates lead to an unsatisfactory treatment status for hepatocellular carcinoma (HCC). HCC is a typical inflammation-driven tumor. Chronic inflammation allows nascent tumors escape immunosurveillance. Chemokines are small, soluble, secreted proteins that can regulate the activation trafficking immune cells during inflammation. Several studies have shown various chemokines with overarching functions...
Abstract Background Migraine is one of the most common neurological disorders that leads to disabilities. However, conventional drug therapy for migraine unsatisfactory. Therefore, this meta-analysis aimed evaluate efficacy and safety calcitonin-gene-related peptide binding monoclonal antibody (CGRP mAb) preventive treatment episodic migraine, provide high-quality clinical evidence therapy.Methods A systematic electronic database search was conducted identify potentially relevant studies....
Since mass effect and secondary brain injuries persist in the pathogenesis of intracerebral hemorrhage, hematoma evacuation within a limited time is reasonable. However, it complex to define an accurate therapeutic window (TTW) for evacuation. In this review, studies about TTW were discussed from four aspects: histopathology, molecular pathophysiology, neuroimaging clinical outcomes. Animal experiments indicated that 6–12 h pathophysiological minimally invasive surgery. Clinical trials...
Objective To investigate the correlation of excision repair cross-complementation group 1(ERCC1) gene methylation status with sensitivity to cisplatin-based concurrent chemoradiotherapy and clinical pathological characteristics in patients cervical squamous cell carcinoma (CSCC). Methods Methylation specific polymerase chain reaction was used determine ERCC1 tissue from 20 healthy people 60 CSCC. All CSCC were treated chemoradiotherapy. The treatment outcomes evaluated using Response...