A5068949418- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Muscle metabolism and nutrition
- High Altitude and Hypoxia
- Liver Disease Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Hepatitis B Virus Studies
- Liver physiology and pathology
- HER2/EGFR in Cancer Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pneumonia and Respiratory Infections
- Axon Guidance and Neuronal Signaling
- Angiogenesis and VEGF in Cancer
- Drug-Induced Hepatotoxicity and Protection
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis Viruses Studies and Epidemiology
- Cancer, Hypoxia, and Metabolism
- Ergonomics and Musculoskeletal Disorders
China Medical University
2019-2025
Huazhong University of Science and Technology
2019-2024
Beijing Center for Disease Prevention and Control
2015-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Tongji Hospital
2019-2024
Air Force General Hospital PLA
2020-2023
Air Force Medical University
2020-2021
First Affiliated Hospital of Zhengzhou University
2016-2017
Liaocheng Center for Disease Control and Prevention
2015
Rutgers, The State University of New Jersey
2014
The prevalence of metabolic-associated fatty liver disease (MAFLD) is rarely reported in Beijing. goal this study was to estimate the and risk factors MAFLD among Beijing adults aged ≥25 years old. A cross-sectional, community-based survey with multistage stratified cluster sampling used. Demographic, transient elastography (TE), biochemical blood examination information collected all subjects study. 32.40% (23,832/73,566). Risk independently associated included male gender (OR = 1.47,...
CoronaVac is an inactivated vaccine containing whole-virion SARS-CoV-2, which has been approved in 43 countries for emergency use as of 26 November 2021. However, the long-term immune persistence still unknown. Here, we reported status antibodies and cellular responses within 12 months after two doses CoronaVac. Such data are crucial to inform ongoing future vaccination strategies combat COVID-19.
This first-in-human study evaluated the safety, immunogenicity, pharmacokinetics, and antitumor activity of onartuzumab, a monovalent antibody against receptor tyrosine kinase MET.This 3+3 dose-escalation comprised three stages: (i) phase Ia dose escalation onartuzumab at doses 1, 4, 10, 20, 30 mg/kg intravenously every 3 weeks; (ii) cohort expansion recommended II (RP2D) 15 mg/kg; (iii) Ib 10 in combination with bevacizumab (15 weeks). Serum samples were collected for evaluation potential...
Oxidative stress is a crucial pathological process that contributes to secondary injury following intracerebral hemorrhage. P2X7 receptor (P2X7R), which activated by the abnormal accumulation of extracellular ATP, plays an important role in regulation oxidative central nervous system, although effects P2X7R-associated after hemorrhage remain unclear. Mouse models were established through stereotactic injection 0.075 U VII collagenase into right basal ganglia. The results revealed P2X7R...
Chronic obstructive pulmonary disease (COPD) is gaining increasing attention, with different subtypes being distinguished for separate research and treatment. The emphysema subtype characterized by widespread alveolar destruction, which may be associated aggravated damage abnormal repair. Type II epithelial cells (AEC2s), known their stem cell potential, have recently emerged as a promising target COPD However, to date, few studies elucidated the specific mechanisms AEC2s induce...
Neutralizing antibody is an important indicator of vaccine efficacy, which IgG the main component. can be divided into four subclasses. Up to now, studies analysing humoral response SARS-CoV-2 vaccination have mostly focused on measuring total IgG, and contribution specific subclasses remains elusive. The aim this study investigate kinetics neutralizing antibodies subclasses, explore their relationships in people vaccinated with inactivated COVID-19 vaccine. We conducted a prospective cohort...
MNRP1685A is a monoclonal antibody to neuropilin-1 (NRP1). We evaluated blood-based pharmacodynamic biomarkers of in two phase I studies assess exposure/response relationships inform target dose and regimen selection.The escalating doses as single agent or combination with bevacizumab. Plasma placental growth factor (PlGF), VEGF, circulating NRP1 (cNRP1) were at multiple time points using meso-scale discovery (MSD) assays ELISA, respectively. PlGF was also measured I/II trial bevacizumab...
Abstract Onartuzumab is a unique, humanized, monovalent (one‐armed) monoclonal antibody (mAb) against the MET receptor. The intravenous (IV) pharmacokinetics (PK) of onartuzumab were investigated in phase I study and II recurrent non‐small cell lung cancer (NSCLC) patients. potential for drug–drug interaction (DDI) was assessed during co‐administration IV with oral erlotinib, by measuring PK both drugs. concentration–time profiles adequately described using two‐compartment model linear...
Transient ischemic attack (TIA) has been widely regarded as a clinical entity. Even though magnetic resonance imaging (MRI) results of TIA patients are negative, potential neurovascular damage might be present, and may account for long-term cognitive impairment. Animal models that simulate human diseases essential tools in-depth study TIA. Previous studies have clarified Dl-3-N-butylphthalide (NBP) promotes angiogenesis after stroke. However, the effects NBP on remain unknown. This aims to...
Backgroud: Beijing was hyper-endemic for hepatitis A until the 1990s and has been vaccinating against since 1994. The objective is to study epidemiology changes of antibody level from 1990 2017.A multistage randomized cluster sampling serological cross-sectional conducted in individuals over one year old 1992, 2006 2014 Beijing. Venous blood samples were collected test anti-HAV antibody. incidence data obtained National Notifiable Disease Reporting System (NNDRS) CDC statistics vaccination...
The alcohol consumption pattern, alcoholic liver disease (ALD) prevalence and related risk factors among drinkers in Beijing haven't been fully elucidated. Hence, a cross-sectional study was conducted to investigate potential link these factors.
Objective To study the tissue-infiltrating immune cells of emphysema phenotype chronic obstructive pulmonary disease (COPD) and find molecular mechanism related to development offer potential targets for more precise treatment patients with COPD. Methods Combined analyses COPD lung tissue-related datasets, GSE47460 GSE1122, were performed. CIBERSORT was used assess distribution cells. Weighted gene co-expression network analysis (WGCNA) select key genes closely clinical features. Rt-qPCR...
Background. When the immunosuppressants cyclosporine (CsA) and sirolimus (SRL) are co-administered to transplant patients, lower doses used than when either drug is given alone. Since both drugs share similar transport metabolic pathways, there potential for an interaction leading unpredictable effects. Furthermore, affect activity of cytochrome P450 3A1/2 (CYP3A1/2), rat parallel human CYP3A4, multidrug transporter P-glycoprotein (Pgp). Methods. To clarify role enzymes membrane transporters...
This study aimed to evaluate the seroprevalence of Bordetella pertussis and persistence antibodies following vaccination. We recruited 6060 healthy subjects from five provinces China during 2017–2018. Serum IgG against toxin (anti-PT IgG) filamentous hemagglutinin (anti-FHA IgG), serum IgA IgA) were measured by ELISA. Geometric mean concentration (GMC), seropositivity rate, recent infection rate calculated. Among 0–6 years-olds, anti-PT IgG, IgA, anti-FHA GMCs 6.4 IU/ml (95% CI 6.1–6.8), 2.8...
Abstract Emphysematous smokers with normal spirometry form a considerable proportion of the clinical population. However, despite presenting respiratory symptoms and activity limitation, they cannot be diagnosed chronic obstructive lung disease (COPD) according to current criteria. Thus, we aimed determine whether emphysema in has different pathogenesis from that patients COPD. We compared 12 pairs tissue samples emphysematous COPD, determined degree using computed tomography. With focus on...
To evaluate the immunogenicity of inactivated COVID-19 vaccines administered at different intervals. Subjects who had received two doses an interval 21 days or 1–7 months were selected to collect 5 ml venous blood after second dose for detection specific IgG antibody against SARS-CoV-2 using chemiluminescent immunoassay. Blood samples collected from 348 and 174 individuals vaccinated months, respectively. Seropositive rate 2 weeks vaccination 21-days was 95.7% 97.1%, respectively, with no...