A5101780500- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Legionella and Acanthamoeba research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Immunotherapy and Biomarkers
- Blood Pressure and Hypertension Studies
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Antifungal resistance and susceptibility
- Single-cell and spatial transcriptomics
- Chronic Myeloid Leukemia Treatments
- Cardiovascular Health and Risk Factors
- Water Treatment and Disinfection
- Fungal Infections and Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nutritional Studies and Diet
- Cytomegalovirus and herpesvirus research
- Pregnancy and preeclampsia studies
- Immune cells in cancer
China Medical University
2015-2024
First Hospital of China Medical University
2008-2024
The University of Texas Health Science Center at Houston
2024
Affiliated Hospital of Qingdao University
2024
Jiangxi Provincial Cancer Hospital
2023-2024
Southern Medical University
2023-2024
North Sichuan Medical University
2024
Affiliated Hospital of North Sichuan Medical College
2023-2024
Nanfang Hospital
2024
Harbin University of Commerce
2024
Pulmonary fibrosis is a progressive and irreversible fibrotic lung disorder with high mortality few treatment options. Recently, induced pluripotent stem (iPS) cells have been considered as an ideal resource for cell-based therapy. Although, earlier study demonstrated the therapeutic effect of iPS on pulmonary fibrosis, exact mechanisms remain obscure. The present investigated effects inflammatory responses, transforming growth factor (TGF)-β1 signaling pathway, epithelial to mesenchymal...
Obesity and insulin levels can influence each other by metabolism. However, their temporal sequences on hypertension are generally unknown, especially in Chinese adults. Recently, some scholars have proposed that triglycerides-glucose index (TyG) is an important indicator of resistance. The study aims to describe the relationship between body mass (BMI) TyG its impact hypertension.A total 4081 adults (56.33% women) without antihypertensive, hypoglycemic or lipid-lowering medications were...
Myeloid lineage cells such as macrophages and dendritic (DCs), targeted by HIV-1, are important vehicles for virus dissemination through the body well viral reservoirs. Compared to activated lymphocytes, myeloid collectively more resistant HIV-1 infection. Here we report that NRP-1, encoding transmembrane protein neuropilin-1, is highly expressed in DCs but not CD4+ T cells, serving an anti-HIV factor inhibit infectivity of progeny virions. Silencing NRP-1 enhanced transmission significantly...
Objective To investigate the change in plasma apelin level patients with stable angina. Methods The study enrolled 96 angina as Stable Angina Group and another 78 outpatients no Control Group. Subjects were excluded if they had a history of acute coronary syndrome, rheumatic heart disease, cardiomyopathy, cardiac arrhythmia, diabetes mellitus, hyperthyroidism, or antecedent hypertension. Plasma levels all subjects determined using commercially available immunoassay. In addition, blood was...
Studies have shown that non-traditional lipid profiles a better association with stroke than traditional blood lipids in clinical applications, other studies drawn different conclusions. This study was large-scale median follow-up of 8.4 years. The hazard ratio (HR) and 95% Confidence interval (CI) variables for risk incident were analyzed by multivariable Cox proportional models. During the follow-up, 502 new strokes (310 ischemic, 187 hemorrhagic, 5 unclassified strokes) occurred among...
Background: The objective was to evaluate the association of hypertriglyceridemic waist (HTGW) phenotype with prediabetes and diabetes (DM) in rural Chinese population. Methods: In a cross-sectional study, 11,579 adults (5361 men 6218 women) aged 35 years or older were recruited from areas China. Anthropometric measurements, laboratory examinations self-reported information collected by trained personnel. HTGW defined as elevated triglycerides circumference. We used logistic regression...
9562 Background: Despite great success of immunotherapy (IO) in advanced melanoma, there remains unmet clinical needs for IO resistant and cold tumors. IBI363 is a first-in-class PD-1/IL-2 α -bias bispecific antibody fusion protein which could block PD-1 checkpoint activate α-bias IL-2 to rejuvenate exhausted tumor-specific T cells. Herein, we report updated results from the phase I study evaluate safety efficacy pts with melanoma. Methods: Eligible melanoma who failed or intolerant standard...
Cordycepin has good antitumor activity, but its clinical application is limited due to the easy deamination of N6 in structure. In this study, a large lipolysis group was introduced at cordycepin improve problem, derivatives (3a–4c) were synthesized, and biological evaluation compounds studied. vitro activity against MCF7 cells, HepG2 cells SGC-7901 evaluated by MTT assay. results, compound 4a showed most obvious inhibitory effect on with an IC50 value 27.57 ± 0.52 μM, which much lower than...
Abstract Mounting evidence has demonstrated the considerable regulatory effects of long noncoding RNAs (lncRNAs) in tumorigenesis and progression various carcinomas. LncRNA Semaphorin 3B (SEMA3B) antisense RNA 1 ( SEMA3B‐AS1 ) been found to be dysregulated a few carcinomas recently. However, its potential function mechanism colorectal carcinoma (CRC) have not yet examined. Here we show that acts as crucial regulator CRC progression. We expression was downregulated cell lines tissues....
Hyperhomocysteinemia (Hhcy) is a known cardiovascular disease (CVD) risk factor. Observational studies had supported the role of lifestyle factors such as physical activity, diet and alcohol consumption in CVD prevention. Our study aimed to determine relationship between Hhcy general Chinese population.In this cross-sectional study, total 7135 adults (3320 men 3815 women) aged 35 years or older were recruited from rural Northeast China. Data on factors, activities, sleep duration, current...
Objective To study the tissue-infiltrating immune cells of emphysema phenotype chronic obstructive pulmonary disease (COPD) and find molecular mechanism related to development offer potential targets for more precise treatment patients with COPD. Methods Combined analyses COPD lung tissue-related datasets, GSE47460 GSE1122, were performed. CIBERSORT was used assess distribution cells. Weighted gene co-expression network analysis (WGCNA) select key genes closely clinical features. Rt-qPCR...
Abstract Background A single-inhaler extrafine triple combination of beclometasone dipropionate (BDP), formoterol fumarate (FF) and glycopyrronium (G) has been developed for maintenance therapy chronic obstructive pulmonary disease (COPD). This study evaluated the efficacy safety BDP/FF/G in patients three eastern Asian areas: China, Republic Korea Taiwan. Methods TRIVERSYTI was a double-blind, randomised, active-controlled, parallel-group with COPD, post-bronchodilator forced expiratory...
Aim: To investigate whether monocyte to HDL cholesterol ratio (MHR) can improve the risk stratification of reduced renal function by estimating atherosclerosis. Patients & methods: The cross-sectional study included 8159 subjects (males: 45.73%, mean age: 54.12 years) from Northeast China in 2013. Results: Each standard deviation increase MHR brought 42.9% additional males. In females, strongly correlated with before it reached a breakpoint (MHR = 0.25). Additionally, net reclassification...
History of first-degree relatives with colorectal cancer is one the most important and common risk factors for in China. Most chronic diseases, such as malignancies, are preventable by adopting health-promoting behaviors other approaches. However, relationships among affecting lifestyles have not been sufficiently studied. This study aimed to test mediation effects Health belief relationship between lifestyle health information literacy cancer.A cross-sectional descriptive design was...
Gastric carcinoma (GC) is a high heterogeneity and malignant tumor with poor prognosis. The current implementation of immunotherapy in GC limited due to the insufficient exploration immune-related mutations speculated early mutation events. Therefore, we performed whole-exome sequencing on 40 patients explore their genetic characteristics, shedding light order events, somatic impacting immune microenvironment, potential biomarkers for immunotherapy. Regarding TP53 disruptions were identified...
Alternative splicing is a crucial cellular process in eukaryotes, enabling the generation of multiple protein isoforms with diverse functions from single gene. To better understand impact alternative on structures, protein-protein interaction and human diseases, we developed ASpdb (https://biodataai.uth.edu/ASpdb/), comprehensive database integrating experimentally determined structures AlphaFold 2-predicted models for isoforms. includes over 3400 canonical isoforms, each represented by both...