A5102811239- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Intracerebral and Subarachnoid Hemorrhage Research
- Medical Imaging and Pathology Studies
- Neurosurgical Procedures and Complications
- Cardiac tumors and thrombi
- Neonatal Respiratory Health Research
- Acute Ischemic Stroke Management
- COVID-19 diagnosis using AI
- Migraine and Headache Studies
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Congenital Heart Disease Studies
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Vascular Anomalies and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Hedgehog Signaling Pathway Studies
- Dental Research and COVID-19
Guangzhou Medical University
2016-2025
First Affiliated Hospital of Guangzhou Medical University
2016-2025
State Key Laboratory of Respiratory Disease
2015-2025
Second Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2024-2025
Inner Mongolia Agricultural University
2025
Guangxi Medical University
2017-2024
Guigang City People's Hospital
2023-2024
Fujian Medical University
2022-2024
First Affiliated Hospital of GuangXi Medical University
2017-2024
Coronavirus disease 2019 (COVID-19), caused by infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is transmitted through droplets and close contact [1–4]. To diagnose COVID-19, oropharyngeal swab (OP swab) sampling widely used for viral nucleic acid detection [3]. However, healthcare workers who perform OP are at high risk due to aerosol from patients during the process sampling. And quality manual swabs inconsistent among different collectors, which may lead...
Abstract The 2019 novel coronavirus was detected in self-collected throat washings. positive testing rate of washing much higher than that nasopharyngeal swabs. Throat is a promising candidate for 2019-nCoV screening and monitoring due to its noninvasiveness reliability.
Pulmonary hypertension related to pulmonary fibrosis is classed as WHO Group III, one of the most common groups which lacks effective treatment options. In this study, we aimed uncover underlying mechanisms, particularly involvement BMP9/BMPR2/SMAD signalling pathway, in subtype hypertension.Male Sprague Dawley rats were used establish a model with fibrosis, induced by bleomycin. Haemodynamic and lung functions measured, along histological immunohistochemical examinations. Primary cultures...
Oxidative stress is a crucial pathological process that contributes to secondary injury following intracerebral hemorrhage. P2X7 receptor (P2X7R), which activated by the abnormal accumulation of extracellular ATP, plays an important role in regulation oxidative central nervous system, although effects P2X7R-associated after hemorrhage remain unclear. Mouse models were established through stereotactic injection 0.075 U VII collagenase into right basal ganglia. The results revealed P2X7R...
Purpose Osteoarthritis (OA) stands as the most prevalent joint disorder. Mitochondrial dysfunction has been linked to pathogenesis of OA. The main goal this study is uncover pivotal role mitochondria in mechanisms driving OA development. Materials and methods We acquired seven bulk RNA-seq datasets from Gene Expression Omnibus (GEO) database examined expression levels differentially expressed genes related utilized single-sample gene set enrichment analysis (ssGSEA), (GSEA), weighted...
The purpose of this study was to investigate the feasibility using 18F-labeled fibroblast activation protein inhibitor (FAPI) PET/CT in assessing fibrotic remodeling pulmonary artery (PA) and right ventricle (RV) arterial hypertension (PAH). Methods: In a rat model monocrotaline-induced PAH, rats were euthanized at different time points for tissue analysis (fibroblast immunofluorescence Masson's trichrome staining) after completing 18F-FAPI hemodynamic measurements. Thirty-eight PAH patients...
Thrombus enhancement sign (TES) has emerged as a potential imaging biomarker in patients with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT). To evaluate the prognostic value of TES on 90-day mortality and functional outcomes. We conducted prospective, two-center study involving 323 AIS treated EVT. was assessed by CT angiography (CTA) using thin-slab maximum intensity projection. The primary outcome mortality; secondary outcomes included measured modified Rankin...
Alfalfa silage has a high proportion of rumen-degradable protein content. Increasing dietary starch (RDS) can enhance ruminal microbial synthesis. This study was conducted to investigate the influence RDS levels in substrates with alfalfa on vitro rumen fermentation and nitrogen (N) utilization. Rumen fluid collected dispensed into anaerobic bottles, each containing 1 g substrate 60 mL fluid–buffer mixture. The composed 40% five different levels: 14.85% RDS, 16.40% 18.67% 20.21% 21.62% RDS....
<b><i>Background:</i></b> Patients with pulmonary tuberculosis (PTB) have a high risk of concomitant tracheobronchial (TBTB), which commonly causes severe complications such as stenosis. The prevalence and predictors TBTB in China remain unclear due to the lack prospective large-scale studies. <b><i>Objectives:</i></b> To investigate incidence PTB patients southern China, elucidate related <b><i>Methods:</i></b> We...
Objective: To assess the prevalence of laryngopharyngeal reflux disease (LPRD) in Fuzhou region. Methods: A total 4100 subjects who aged from 10 to 70 years derived a random cluster sampling fourty districts region and they were asked complete questionnaires. According grade standard symptom index (RSI), with score more than 13 defined as having LPRD. The factors associated LPRD evaluated corrective analysis. Results: Effective questionnaires obtained 4 063 100 subjects. was 5.00%(203/4...
Background . The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development hemorrhagic stroke. present study attempts verify whether NLRP6 plays an important role in and identify critical microRNA during process. Methods Suitable simulated cerebral environments were established vitro vivo BV2 cells treated with hemin induce cell damage. Collagenase was used establish a model mouse hemorrhage. relationship...
The aetiological composition and clinical characteristics of patients with pulmonary hypertension (PH) hospitalised in the respiratory department were retrospectively analysed, as well correlation between transthoracic echocardiography (TTE) right heart catheterization (RHC) for evaluating artery systolic pressure (PASP) mean (mPAP).Of 731 patients, 544 (74.42%) diagnosed PH by RHC. Pulmonary arterial (PAH) was most common type PH, accounting 30.10%; due to lung disease and/or hypoxia...
Lymphotoxin beta receptor (LTBR) is a positive T cell proliferation regulator gene. It closely associated with the tumor immune microenvironment. However, its role in cancer and immunotherapy unclear. Firstly, expression level prognostic value of LTBR were analyzed. Secondly, clinical stages, subtypes, molecular subtypes was The correlation between regulatory genes, checkpoint RNA modification genes then Correlations cells, scores, cancer-related functional status, stemness index, mismatch...
Rationale: Epithelioid hemangioendothelioma (EHE) is a rare, low to moderate-grade malignancy, even less in pulmonary endovascular neoplasm. Patients with EHE have no optimal treatment, resulting poor prognoses. Patient concerns: We reported 42-year-old man multiple mild metabolic uptakes filling defect maximum standardized uptake value of 4.5 by 18-fluorodeoxyglucose/fibroblast associated protein inhibitor-positron emission tomography/ computed tomography. Anticoagulant treatment was not...
The Hedgehog (Hh) signaling pathway has been implicated in the pathogenesis of various cancers. However, roles downstream GLI family (GLI1, GLI2, and GLI3) tumorigenesis remain elusive. This study aimed to unravel genetic alterations GLI1/2/3 cancer their association with immune microenvironment related pathways. Firstly, we evaluated expression profiles different types, analyzed prognostic predictive values, assessed correlation tumor-infiltrating cells. Secondly, explored relationships...
This research evaluates the effect of balloon pulmonary angioplasty (BPA) on cardiac electrophysiological changes in patients with chronic thromboembolic hypertension (CTEPH).
Purpose: Prolyl 4-hydroxylase subunit alpha 3 (P4HA3) is implicated in several cancers' development. However, P4HA3 has not been reported other cancers, and the exact mechanism of action currently unknown. Materials methods: First, expression profile was analyzed using a combination University California Santa Cruz (UCSC) database, Cancer Cell Line Encyclopedia (CCLE) Genotype-Tissue Expression (GTEx) database. UniCox Kaplan-Meier were used to analyze predictive value P4HA3. The clinical...