The continued expand of the coronavirus disease 19 (COVID-19) pandemic, confinement measures and an urgent change in education nursing students from traditional to distance learning throughout country affect mental health university students. This study analyzed state-trait anxiety levels because e-Learning during two periods COVID-19 confinement. A mixed follow-up was used, which evaluates same cohort cross-sectionally but with a longitudinal component. sample 460 Nursing Degree at...

Background: Glutathione peroxidase-1 (GPX1) is a member of the GPX family, which considered an enzyme that interacts with oxidative stress. GPX1 differential expression closely correlated carcinogenesis and disease progression. In this study, we used bioinformatics analysis to investigate level explore prognostic information in different human cancers. Methods: Expression was analyzed via Oncomine database Gene Profiling Interactive Analysis tool, potential evaluated using UALCAN, GEPIA,...

Purpose Osteoarthritis (OA) stands as the most prevalent joint disorder. Mitochondrial dysfunction has been linked to pathogenesis of OA. The main goal this study is uncover pivotal role mitochondria in mechanisms driving OA development. Materials and methods We acquired seven bulk RNA-seq datasets from Gene Expression Omnibus (GEO) database examined expression levels differentially expressed genes related utilized single-sample gene set enrichment analysis (ssGSEA), (GSEA), weighted...

Recent studies reported that long noncoding RNAs (LncRNAs) were involved in tumorigenesis of various human cancer types, including gastric (GC) through targeting microRNAs (miRNAs/miRs). The present study investigated the biological functions LncRNA SOX2 overlapping transcript (SOX2OT)/miR‑194‑5p axis and its underlying mechanism tumor progression GC. results showed relative expression SOX2OT was highly upregulated while miR‑194‑5p down‑regulated GC tissues cell lines (MGC‑803, SGC‑7901,...

The Dickkopf1 (DKK1) gene encodes a protein that belongs to the Dickkopf family. can inhibit Wnt signaling pathway which plays key role in carcinogenesis and progression of various types cancers. Based on this, we hypothesized differential expression DKK1 may figure significantly cancers by regulating transduction. In this study, conducted bioinformatics analysis evaluate prognostic therapeutic value level human cancers.The was analyzed using Oncomine database Gene Expression Profiling...

Although there are studies that show some pesticides produce gonadal dysfunction and cancer in different animals, not many studiesregardinghumans. This study determined the prevalence risk humans of developing ovarian or testicular areas with distinct exposure to pesticides, which have endocrine disrupting properties. A population-based case-control was carried out on living ten health districts Andalusia (Southern Spain) classified as high low environmental according agronomic criteria. The...

Lymphotoxin beta receptor (LTBR) is a positive T cell proliferation regulator gene. It closely associated with the tumor immune microenvironment. However, its role in cancer and immunotherapy unclear. Firstly, expression level prognostic value of LTBR were analyzed. Secondly, clinical stages, subtypes, molecular subtypes was The correlation between regulatory genes, checkpoint RNA modification genes then Correlations cells, scores, cancer-related functional status, stemness index, mismatch...

Pregnancy monitoring is vital to guaranteeing that both the foetus and mother are in optimal health conditions. WHO protocols recommend at least eight medical examinations during pregnancy period. While cancellation or reduction of appointments due pandemic may help reduce risk infection, it could also negatively influence perinatal outcomes birthing process. The aim this research was analyse differences birth characteristics two groups pregnant women: women who gave before pandemic, whether...

Purpose: Prolyl 4-hydroxylase subunit alpha 3 (P4HA3) is implicated in several cancers' development. However, P4HA3 has not been reported other cancers, and the exact mechanism of action currently unknown. Materials methods: First, expression profile was analyzed using a combination University California Santa Cruz (UCSC) database, Cancer Cell Line Encyclopedia (CCLE) Genotype-Tissue Expression (GTEx) database. UniCox Kaplan-Meier were used to analyze predictive value P4HA3. The clinical...

Purpose: Osteoarthritis (OA) is a disease of senescence and inflammation. Hedgehog’s role in OA mechanisms unclear. This study combines Bulk RNA-seq scRNA-seq to identify Hedgehog-associated genes OA, investigating their impact on the pathogenesis OA. Materials methods: Download merge eight bulk-RNA seq datasets from GEO, also obtain dataset for validation analysis. Analyze Hedgehog pathway activity using datasets. Use ten machine learning algorithms important genes, validate predictive...

The Hedgehog (Hh) signaling pathway has been implicated in the pathogenesis of various cancers. However, roles downstream GLI family (GLI1, GLI2, and GLI3) tumorigenesis remain elusive. This study aimed to unravel genetic alterations GLI1/2/3 cancer their association with immune microenvironment related pathways. Firstly, we evaluated expression profiles different types, analyzed prognostic predictive values, assessed correlation tumor-infiltrating cells. Secondly, explored relationships...

Autism spectrum disorder (ASD) is a specific type of pervasive developmental disorder, and most studies suggest that the onset autism may be related to genetic immune factors. The etiology underlying molecular events need further addressed.The ASD-related dataset GSE18123 was downloaded from Gene Expression Omnibus (GEO) database. set enrichment analysis (GSEA) used screen for Ontology (GO) terms Kyoto Encyclopedia Genes Genomes (KEGG) pathways associated with autism. top 5,000 genes an...

Background: Ferroptosis is a newly discovered type of regulated cell death, the underlying mechanisms which need to be further illuminated. The regulatory activity miR-28-5p in ferroptosis colon cancer cells currently unclear. This study set out investigate effect on and determine its mechanism. Methods: Biochemical Kits were used measure iron concentration, malondialdehyde (MDA) glutathione (GSH) concentration peroxidase (GPX) vitality. Cell counting kit 8 (CCK8) assays conducted evaluate...

Chen, Chuanliang; Zou, Xiaochong; Jiang, Mingyang; Zhang, Ke; Wei, Ruqiong Author Information

T cells are the key to killing tumor cells. However, exact mechanism of their role in cancer is not fully understood. Therefore, a comprehensive understanding T-cell proliferation regulatory genes tumors needed. In our study, we investigated expression levels controlling proliferation, impact on prognosis, and genetic variations. Additionally, explored associations with TMB, MSI, ESTIMATEScore, ImmuneScore, StromalScore, immune cell infiltration. We examined these cancer-related pathways...

Although transcranial magnetic stimulation (TMS)-based closed-loop (TBCL) modality was seldom recommended for functional restoring following spinal cord injury (SCI), several studies recently came to a positive suggestion.To explore the independent factors which influence activity of daily living (ADL) gain, and systematically investigate efficacy TBCL ADL gain.A retrospective observational study.The First Affiliated Hospital Guangxi Medical University.SCI patients with neurological...