A5100420972- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Health disparities and outcomes
- Aging and Gerontology Research
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Dementia and Cognitive Impairment Research
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Ocular Diseases and Behçet’s Syndrome
- Intergenerational Family Dynamics and Caregiving
- Complement system in diseases
- COVID-19 Impact on Reproduction
- Retirement, Disability, and Employment
- Cardiovascular Health and Risk Factors
- Peripheral Neuropathies and Disorders
- COVID-19 and Mental Health
- Palliative Care and End-of-Life Issues
- Long-Term Effects of COVID-19
- Cardiac Health and Mental Health
- Optimism, Hope, and Well-being
- Hepatitis Viruses Studies and Epidemiology
Beijing Center for Disease Prevention and Control
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Center for Disease Control
2023
Peking Union Medical College Hospital
2023
Capital Medical University
2023
Hunan Cancer Hospital
2023
Institute of Psychology, Chinese Academy of Sciences
2011-2022
Guilin University of Electronic Technology
2021
Chinese Academy of Sciences
2012
Objective In China, the rapid socioeconomic transition and consequential traditional culture change had significant influences on Chinese older‐adult depression. present study, prevalence, potential risk, protective factors of depression in older population were investigated. Methods A cross‐sectional survey was conducted with a nationwide representative sample 4945 adults; Center for Epidemiologic Studies Depression Scale (CES‐D) used as measurement tool depressive symptoms. Demographic...
CoronaVac is an inactivated vaccine containing whole-virion SARS-CoV-2, which has been approved in 43 countries for emergency use as of 26 November 2021. However, the long-term immune persistence still unknown. Here, we reported status antibodies and cellular responses within 12 months after two doses CoronaVac. Such data are crucial to inform ongoing future vaccination strategies combat COVID-19.
Neutralizing antibody is an important indicator of vaccine efficacy, which IgG the main component. can be divided into four subclasses. Up to now, studies analysing humoral response SARS-CoV-2 vaccination have mostly focused on measuring total IgG, and contribution specific subclasses remains elusive. The aim this study investigate kinetics neutralizing antibodies subclasses, explore their relationships in people vaccinated with inactivated COVID-19 vaccine. We conducted a prospective cohort...
To determine whether there is an association between CFH, ARMS2, HTRA1, VEGF, SERPING1 or C3 genotypes and patient response to treatment with intravitreal bevacizumab for neovascular age-related macular degeneration (AMD).This was a multicenter prospective study. One hundred forty four patients AMD treated were recruited from 13 centers. Twelve SNPs genotyped using Sequenom. Visual acuity score (VAS), central retinal thickness maximum of lesion measured at each visit.For the CFH rs800292...
This real-world study explores the effect of coronavirus disease 2019 (COVID-19) inactivated vaccines on prevention asymptomatic or mild Delta Omicron variant infections progressing to pneumonia. Association between severe acute respiratory syndrome 2 (SARS-CoV-2) pneumonia cases and vaccination was measured with a multivariable logistic regression, stratified by genotype age groups. We recruited 265 (111 (41.9%) infected 154 (58.1%) variants). There were 22 individuals, 156 without...
Purpose. To identify the predictors of visual response to bevacizumab treatment neovascular age-related macular degeneration (AMD). Design. A cohort study within Neovascular AMD Treatment Trial Using Bevacizumab (NATTB). Methods. This was a multicenter trial including 144 participants from NATTB study. Visual outcomes measured by change in acuity (VA) score, proportion gaining ≥15 letters, and central retinal thickness (CRT) were compared among groups according baseline, demographic, ocular...
The intranasal spray COVID-19 vaccine was made available for the first time in China, it is necessary to understand receivers' satisfaction and experience toward help optimize vaccination service. A self-administered multicenter cross-sectional questionnaire survey conducted Beijing, December 2022. evaluated through three dimensions: immediate tolerance, smooth progress, time-saving. Vaccine acceptability measured by preference over intramuscular injection after their recommendation...
To evaluate the immunogenicity of inactivated COVID-19 vaccines administered at different intervals. Subjects who had received two doses an interval 21 days or 1–7 months were selected to collect 5 ml venous blood after second dose for detection specific IgG antibody against SARS-CoV-2 using chemiluminescent immunoassay. Blood samples collected from 348 and 174 individuals vaccinated months, respectively. Seropositive rate 2 weeks vaccination 21-days was 95.7% 97.1%, respectively, with no...
A rising rate of suicide among the elderly in rural China has been recognized to be triggered by mental health-associated factors. This study uses 3,397 sampled adults from Labor-force Dynamic Survey 2016 explore response mechanism through which non-agricultural employment participation can influence their health. Utilizing Multivariate Regression, Instrumental Variable and Propensity Score Matching methods, we find that, who participate local significantly improve Self-employment tends have...
Purpose. The etiology of neovascular age-related macular degeneration (nAMD) cannot be completely explained by identified environmental risk factors or single-locus gene variants. This study was to explore the potential interactions among variants on nAMD in Chinese population. Methods. 43 SNPs located different genes were genotyped 932 individuals (464 patients and 468 controls). We explored using generalized multifactor dimensionality reduction (GMDR) algorithm method measure departure...
To determine the status of immune responses after primary and booster immunization for SARS-CoV-2 variants evaluate differences in disease resistance based upon titers neutralizing antibodies (NAbs) against variants.Participants aged 18-59 years received 2 doses inactivated COVID-19 vaccine, 14 days apart, a dose 12 months. Blood samples were collected before vaccination (baseline), 1 6 months immunization, at multiple instances within 21 dose. NAbs spike protein Wuhan-Hu-1 3 measured using...
To evaluate the neutralizing antibody (NAb) levels against SARS-CoV-2 Omicron variants BF.7, BQ.1, BQ.1.1, XBB.1, and XBB.1.5 after vaccination natural infection.
Amid the ongoing global COVID-19 pandemic, limited literature exists on immune persistence after primary immunization and immunogenic features of booster vaccines administered at different time intervals. Therefore, this study aimed to determine attenuation neutralizing antibodies against SARS-CoV-2 wild-type strain, Delta Omicron variants 12 months administration inactivated vaccine evaluate response a A total 514 individuals were followed up vaccinated with booster. Neutralizing strain...
Abstract Background With more and new vaccines being developed flooding the market, governments must decide which priority to include in public health programs. Many WHO-recommended were slow be included into national local routine immunization China. We aimed construct a comprehensive vaccine evaluation indicator framework provide basis for program. Methods an pool inclusion through experts' consultation, literature review, group discussion. The modified Delphi method was applied consult 22...
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination service system lacks standardized indicators to assess resource allocation, and limited data are available on convenience- accessibility-related factors. objective of this study was allocation investigate factors.Methods: From October 12, 2022, May 2023 in Beijing, information collected through survey tables questionnaires. Five were established evaluate services used for clustering analysis. Generalized...
Background: This study aimed to evaluate the neutralizing antibody (NAbs) levels against SARS-CoV-2 Omicron variants BF.7, BQ.1, BQ.1.1, XBB.1, and XBB.1.5.Methods: The NAbs different viral strains of 490 infected 187 uninfected individuals during Beijing December 2022 January 2023 outbreak were analyzed.Findings: In without prior infection, administration two vaccine doses resulted in limited production both prototype variant strains. Nevertheless, a notable increase was observed when three...
Background: Uninfected and unvaccinated older adults were most vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection illness. Exploring both the barriers facilitators of vaccination among these people is very important.Methods: We investigated participants aged ≥80 years without SARS-CoV-2 history from 5 April 2023 May 2023, in Beijing, China. The data collected through door-to-door interviews or telephone surveys using a questionnaire. Participants divided...
Governments must decide which vaccine priority to include in their public health programs. Using the modified Delphi and entropy method, we developed an indicator framework for inclusion at national, provincial, municipal, district/county levels, each containing three dimensions. In total, 4 primary indicators, 17 secondary 45 tertiary indicators were selected, covering vaccine-preventable diseases, candidate vaccines, social drivers of supply demand sides. From a subjective perspective,...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination service system lacks standardized indicators to assess resource allocation. Moreover, data on specific vaccination-promoting measures is limited. This study aimed evaluate accessibility and capacity investigate convenience-related factors in China during the Omicron variant epidemic. We collected information SARS-CoV-2 services among sites Beijing. Analysis was performed using nearest neighbor, Ripley's K, hot spot...
Introduction. The societal burden of cognitive impairments in China has prompted researchers to develop clinical prediction models aimed at making risk assessments that enable preventative interventions. However, it is unclear which factors best predict future impairment and if predictive ability consistent across different socioeconomic groups. Methods. We quantified the demographics, instrumental activities daily living, tests, social factors, psychological diet, exercise sleep, chronic...