Parkinson's disease (PD) is one of the most prevalent forms synucleinopathies, and it characterized neuropathologically by presence intracellular inclusions composed primarily protein α-synuclein (α-syn) in neurons. The previous immunotherapy targeting α-syn PD models with monoclonal antibodies has established as an effective target for neuronal cell death. However, due to essential weaknesses antibody unique features aptamers, aptamers could represent a promising alternative currently used...

Objective To compare medium-term clinical and radiological outcomes of primary unilateral uncemented (UN) or cemented (CE) femoral component total hip arthroplasty (THA) in elderly patients with osteoporosis. Methods Consecutive osteoporosis who underwent UN CE THAs at our institution from 2006 to 2013 were retrospectively reviewed. All consecutive procedures managed by high-volume surgeons, using THA approaches. Follow-up assessments occurred 1, 3, 6, 9, 12 months postoperatively, yearly...

As social media platforms have become significant sources of information during the pandemic, a volume both factual and inaccurate related to prevention COVID-19 has been disseminated through media. Thus, disparities in verification across populations potential promote dissemination misinformation among clustered groups people with similar characteristics.This study aimed identify characteristics users who obtained unofficial accounts were (1) most likely change their health behaviors...

This real-world study explores the effect of coronavirus disease 2019 (COVID-19) inactivated vaccines on prevention asymptomatic or mild Delta Omicron variant infections progressing to pneumonia. Association between severe acute respiratory syndrome 2 (SARS-CoV-2) pneumonia cases and vaccination was measured with a multivariable logistic regression, stratified by genotype age groups. We recruited 265 (111 (41.9%) infected 154 (58.1%) variants). There were 22 individuals, 156 without...

Alpha-synuclein (α-Syn) is a neuronal protein that highly implicated in Parkinson's disease (PD), and phosphatase 2A (PP2A) an important serine/threonine associated with neurodegenerative diseases, such as PD. α-Syn can directly upregulate PP2A activity, but the underling mechanism remains unclear. Therefore, we investigated molecular of regulating activity.α-Syn its truncations were expressed E.coli, purified by affinity chromatography. Cα mutants recombinant baculovirus, chromatography...

The novel coronavirus (COVID-19) has infected more than 1,000,000 people in at least 120 countries. Data collection the ascending phase is crucial to deal with a rapidly evolving crisis by understanding uncertain relation between risk communication and psychological responses. were collected from 26th Jan 2020 (at which time 30 Provinces launched first level response major public health emergencies China) until 17th February (1,775 deaths 71,429 confirmed cases worldwide) mean test-retest...

Introduction: An outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. This study aimed to analyze the clinical and epidemiologic characteristics patients with COVID-19 better differentiate suspected Beijing, China.
 Methodology: was a retrospective, single-center study. Clinical data were collected from admitted Beijing Ditan Hospital January 29 February 21, 2020.
 Results: One hundred six (60 males 46 females, median age 36 years) enrolled....

Clinical and epidemiological knowledge of 2019 novel coronavirus disease (COVID-19) is limited. We reported a family cluster severe acute respiratory syndrome 2 (SARS-CoV-2) cases in Beijing, China. This comprised three laboratory confirmed with clinical symptoms. All patients had close contact relative from Wuhan, Hubei Province. Throat swab samples were all positive for SARS-CoV-2 using real-time reverse transcriptase-polymerase chain reaction assays. Chest computerized tomography revealed...

Research has shown that the meaningfulness of material increases judged size, whereas symmetry decreases size judgments. These findings have been interpreted in terms information processing, with a greater quantity leading to judgment larger size. An alternative view based on biofunctional understanding theory emphasizes quality affordance-triggered biological activity as reported and observed attitudes toward playing sports, effortless understanding, knowledge-in-action, meditative wisdom,...

Objective To compare surgical complications and functional outcomes of the ring plate versus non-ring approach to repair scapular body fractures (SBFs; AO/OTA classification: 14-A2.2). Methods This retrospective study reviewed data from adults with SBFs who underwent a modified Judet combined or plates between November 2006 June 2013. The primary were Constant Murley score Disabilities Arm, Shoulder Hand (DASH) score. secondary radiographic findings. Results A total 318 patients had internal...

This paper evaluated the impacts of various factors on youngcyclist's intention aberrant crossing behaviors at intersections.Bicycles were classified into conventional bikes and electric (hereinafter referred to as e-bikes).Data collected from 374 participants in Nanjing, China.The hierarchical multiple linear regressionanalysis was conducted estimate factor variablesbased theory planned behavior (TPB).The results showed that three key traditional TPB variables including attitudes,...

The introduction of Purchase Money Security Interest (PMSI) to our country has expanded China's system security interests. structures title retention and financial lease created based on parties' consensus are blurred by the function security, deviating from legal property rights, ignoring true meaning parties, resulting in effectiveness equivalent Although retention, leasing PMSI all have functional value guaranteeing price claims, Article 388 Civil Code enriched content guarantee contracts...

While several initiatives, including monetary rewards and performance system reform, are used to inspire medical staff, none fully effective. We sought describe the intrinsic drive of staff identify elements that improve work enthusiasm by increasing internal motivation.A cross-sectional study was conducted in which 2,975 employee representatives from 22 municipal hospitals Beijing, China were interviewed using a self-made motivation scale for includes achievement motivation, self-efficacy,...

COVID-19 (coronavirus disease 2019) is an infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and discovered in 2019. The clinical manifestations include fever, coughing, difficulty breathing even death from multiple organ failure. Nucleic acid test the golden standard method for confirmation of infection. According to Chinese 'Seventh Edition Diagnosis Treatment Protocol', suspected patients with negative nucleic tests two consecutive airway specimens can be...

<sec> <title>BACKGROUND</title> As social media platforms have become significant sources of information during the pandemic, a volume both factual and inaccurate related to prevention COVID-19 has been disseminated through media. Thus, disparities in verification across populations potential promote dissemination misinformation among clustered groups people with similar characteristics. </sec> <title>OBJECTIVE</title> This study aimed identify characteristics users who obtained unofficial...