A5101508508- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Retinal and Optic Conditions
- Corneal surgery and disorders
- Neonatal Health and Biochemistry
- Retinal and Macular Surgery
- Cytomegalovirus and herpesvirus research
- Advanced Radiotherapy Techniques
- Surgical Simulation and Training
- Retinal Development and Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ocular Disorders and Treatments
- Climate Change and Health Impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Pancreatitis Pathology and Treatment
- Metabolomics and Mass Spectrometry Studies
- Ocular Surface and Contact Lens
- Esophageal and GI Pathology
- Ocular Oncology and Treatments
- Lung Cancer Diagnosis and Treatment
Peking University People's Hospital
2010-2025
Peking University
2010-2025
Ministry of Education of the People's Republic of China
2012-2018
University of Maryland, Baltimore
2010-2014
Association for Research in Vision and Ophthalmology
2014
American Academy of Ophthalmology
2014
University of California, San Francisco
2013
Albert Einstein College of Medicine
2013
Montefiore Medical Center
2013
Washington University in St. Louis
2009
We explored associations between age-related macular degeneration (AMD) and genetic variants of 10 genes in a nationwide Chinese population.In this multicenter case-control study, 535 AMD patients 469 controls were recruited from 16 centers that spread the north to south China. All participants underwent comprehensive eye examinations, 40 single nucleotide polymorphisms (SNPs) selected. DNA samples genotyped with MassArray system. The effect genotypes haplotypes on was assessed logistic...
The aim of this study was to assess the effect various tube parameters on corneal endothelial cell density (ECD) after insertion Ahmed valves.Thirty-nine eyes 33 patients with previous superotemporal (ST) valve implantation and 20 13 participants uncomplicated phacoemulsification intraocular lens but no history glaucoma surgery were evaluated. Various measured anterior segment optical coherence tomography. ST, central, inferonasal (IN) ECD pachymetry measured. Endothelial loss thickness in...
Purpose: To reveal molecular mechanisms of diabetic retinopathy (DR) in Asians and facilitate the identification new therapeutic targets through untargeted metabolomics. determine differences serum metabolites metabolic pathways between different stages patients with type 2 mellitus (T2DM) proliferative DR (PDR) non-proliferative (NPDR) identify differential T2DM (NPDR PDR) patients. Methods: This prospective observational registration study described 45 15 control cases no significant...
Purpose To evaluate and contrast the effectiveness safety of two conbercept treatment protocols—a three-dose treat-and-extend (3+T&E) regimen a pro re nata (3+PRN) regimen—in Chinese patients diagnosed with neovascular age-related macular degeneration (nAMD).
Age-related macular degeneration (AMD) is a leading cause of irreversible central blindness among the elderly worldwide. We use exome sequencing to analyse nonsynonymous single-nucleotide variants (SNVs) across whole genome 216 neovascular AMD cases and 1,553 controls. As follow-up validation, we evaluate 3,772 6,942 controls from five independent cohorts in East Asian population. Here show strong evidence an association at novel, missense SNV, rs7739323, which located ubiquitin protein...
To determine whether there is an association between CFH, ARMS2, HTRA1, VEGF, SERPING1 or C3 genotypes and patient response to treatment with intravitreal bevacizumab for neovascular age-related macular degeneration (AMD).This was a multicenter prospective study. One hundred forty four patients AMD treated were recruited from 13 centers. Twelve SNPs genotyped using Sequenom. Visual acuity score (VAS), central retinal thickness maximum of lesion measured at each visit.For the CFH rs800292...
We determined the receiver operating characteristic (ROC) curves for Peristat online perimetry at detecting varying degrees of glaucoma and correlation between Humphrey visual field.A prospective, comparative study (an achromatic static computer threshold testing program) field (HVF) 24-2 SITA standard was performed by 63 patients 30 healthy controls in random order. The number total adjacent abnormal test points were identified each test, compared with Spearman correlation. Receive...
Background Branch retinal vein occlusion (BRVO) is a common vascular disorder of the elderly and both intravitreal triamcinolone acetonide (TA) bevacizumab were reported to be effective. The purpose this study was compare with TA for treatment macular edema resulting from BRVO. Methods retrospectively comparative interventional included group 34 BRVO patients (1.25 mg bevacizumab) (4.0 TA), two groups matched by baseline best corrected visual acuity (BCVA). Examinations designed carried out...
Purpose. To identify the predictors of visual response to bevacizumab treatment neovascular age-related macular degeneration (AMD). Design. A cohort study within Neovascular AMD Treatment Trial Using Bevacizumab (NATTB). Methods. This was a multicenter trial including 144 participants from NATTB study. Visual outcomes measured by change in acuity (VA) score, proportion gaining ≥15 letters, and central retinal thickness (CRT) were compared among groups according baseline, demographic, ocular...
Background Age-related degeneration(AMD) and asthma are both diseases that related to the activation of complement system. The association between AMD has been debated in previous studies. authors investigated relationship systemically. Principal Findings epidemiological study showed was choroidal neovascularization(CNV) subtype(OR = 1.721, P 0.023). However, meta-analysis there no asthma. In an animal model, we found more fluoresce leakage CNV lesions by FA analysis angiogenesis...
Purpose: To determine whether long-term, slow-release exposure to corticosteroids with Retisert promotes better surgical outcomes after Ahmed valve implantation. Patients: This comparative retrospective cohort study included 17 eyes (10 patients) uncontrolled uveitis requiring and implantation, 55 control (51 other types of medically glaucoma that only received Ahmed. Materials Methods: Main outcome measures were intraocular pressure (IOP), eye drops per day, best-corrected visual acuity,...
Purpose: To evaluate the safety and efficacy of continuous high-dose (6 mg) intravitreal ganciclovir injections (IVG) for cytomegalovirus (CMV) retinitis (CMVR) after haploidentical hematopoietic stem cell transplantation (Haplo-HSCT), to explore factors that may influence treatment procedure. Design: Prospective, randomized, single-blinded, positive-controlled, interventional, comparative study. Methods: A total 22 patients with CMVR (32 eyes) were randomized either group (IVG 6 mg weekly)...
Objective: To explore clinical and laboratory factors that influencing treating procedure of cytomegalovirus retinitis (CMVR) after allogeneic bone marrow hematopoietic stem cell transplantation (HSCT). Methods: This is a retrospective case series study. A total 9 CMVR patients (15 eyes) between January 2016 March 2017 were included in this All received intravenous or oral ganciclovir, together with intravitreous injection ganciclovir alone combined foscanet sodium. One day before the first...
Objective To observe the clinical characteristics of polypoidal choroidal vasculopathy (PCV).Methods Two hundreds fifty-four PCV patients (306 eyes) were enrolled in this study.All examined for corrected visual acuity (BCVA) testing,slit-lamp microscope,indirect ophthalmoscopy,fundus photography,fluorescein angiography,indocyanine green angiography and optic coherence tomography.Results The included 152 males (59.8％) 102 females (40.2％) ; age was from 38 to 91 years,with a mean (65.4±8.9)...
Purpose: To explore the efficiency and safety of surgical procedure pars plana vitrectomy (PPV) with silicone oil (SO) tamponade without internal limiting membrane (ILM) peeling for myopic foveoschisis (MF) eyes high risk macular hole formation. Methods: Three (three patients) MF foveal detachment were enrolled into study. Comprehensive preoperative ophthalmological assessments, including best corrected visual acuity (BCVA) spectral-domain optical coherence tomography (SD-OCT) performed on...