A5101721517- Retinopathy of Prematurity Studies
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Neonatal Respiratory Health Research
- Vascular Malformations Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Ocular Disorders and Treatments
- Advanced Numerical Analysis Techniques
- Redox biology and oxidative stress
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Glutathione Transferases and Polymorphisms
- Assisted Reproductive Technology and Twin Pregnancy
- Traumatic Ocular and Foreign Body Injuries
- Neurological and metabolic disorders
- Ocular Infections and Treatments
- Neurological diseases and metabolism
- Corneal Surgery and Treatments
- Ubiquitin and proteasome pathways
- Medical Research and Treatments
- Photodynamic Therapy Research Studies
Peking University People's Hospital
2016-2025
Peking University
2016-2025
Chengdu Fifth People's Hospital
2023
Lanzhou Veterinary Research Institute
2023
University of California, Irvine
2023
Yangzhou University
2023
Wuhan Prevention and Treatment Center for Occupational Diseases
2017
Ministry of Education of the People's Republic of China
2015
Purpose: To reveal molecular mechanisms of diabetic retinopathy (DR) in Asians and facilitate the identification new therapeutic targets through untargeted metabolomics. determine differences serum metabolites metabolic pathways between different stages patients with type 2 mellitus (T2DM) proliferative DR (PDR) non-proliferative (NPDR) identify differential T2DM (NPDR PDR) patients. Methods: This prospective observational registration study described 45 15 control cases no significant...
Intravitreal injection of conbercept (IVC) is the latest applied treatment that could be used in retinopathy prematurity (ROP) patients. The structural outcomes and recurrence ROP among patients treated with IVC or intravitreal ranibizumab (IVR) were compared.A consecutive case series IVR retrospectively studied. primary outcome was success defined as regression plus disease. secondary plus, times injection, final disease.A total 48 eyes (24 patients) included. Twenty (10 received IVC, 28...
To analyze the demographic characteristics of retinopathy prematurity (ROP) in China, attempting to propose optimized screening criteria and hopefully providing valuable information for future updates ROP guideline. A multicenter, retrospective-cohort study was conducted. The included infants born between January 1, 2018, July 31, 2023, who underwent were diagnosed with at seven centers China. Examinations carried out accordance guidelines 2014: a gestational age (GA)<32 weeks and/or birth...
Abstract Purpose To compare the anatomical outcomes of different extents internal limiting membrane ( ILM ) peeling in idiopathic macular hole surgery. Methods Prospective, parallel‐group, randomized clinical trial. A total 121 eyes patients with underwent pars plana vitrectomy, and a diameter two disk diameters DD or 4 based on randomization. The main outcome was proportion complete closure at 12 months. second grading stratified by index MHCI each visit. Results At months, there no...
To compare the efficacies and treatment outcomes of intravitreal anti-VEGF agents laser therapy in retinopathy prematurity (ROP).A retrospective, non-randomized, comparative study patients diagnosed with type 1 ROP or aggressive posterior (A-ROP) treated as primary at People's Hospital Peking University.A total 1,627 eyes 862 were included. In Group 1, 399 204 A-ROP zone I ROP. The initial regression subgroup was better than that subgroup, reactivation rate progression to retinal detachment...
Purpose To investigate the postmenstrual (PMA) age at treatment of severe retinopathy prematurity (i.e. Type 1 prethreshold or threshold) in infants a tertiary referral center China. Principal Findings 76.6% (359/469) were treated for threshold disease. 67.5% (317/469) had birth weight (BW) 1250g above and almost 30% (126) gestational (GA) 32 weeks above. There was little difference characteristics ROP. After controlling GA, PMA highest with BW ≥2000g (mean 40.3±4.4 weeks, p<0.001); after...
Purpose: To investigate the clinical findings in Chinese patients diagnosed with familial exudative vitreoretinopathy (FEVR) and carrying pathogenic mutations. Methods: One hundred twenty unrelated FEVR were enrolled this study. Genomic DNA ophthalmic examinations collected from all their available relatives. Targeted next-generation sequencing was performed to detect In silico programs used evaluate pathogenicity of Results: Eighty identified mutations found 81 (31/81 LRP5, 25/81 FZD4,...
To describe the changes in characteristics of infants treated for severe retinopathy prematurity (ROP) a tertiary referral unit China after screening guidelines were issued 2004 and to evaluate effectiveness current criteria.Information on consecutive referred single eye department treatment Stage 3 (Type 1 pretheshold threshold disease), 4, 5 ROP between January 2001 May 2012 was retrieved from medical records.The mean gestational age 29.98 ± 2.13 weeks (range 26-34 weeks), birth weight...
This study was to examine the expression of total vascular endothelial growth factor (VEGF) and anti-angiogenic VEGF 165 b isoform in vitreous body retinopathy prematurity (ROP) patients, further role splicing development ROP.This a prospective clinical laboratory investigation study. All patients enrolled received standard ophthalmic examination with stage 4 ROP that required vitrectomy collect samples. The control samples were from congenital cataract patients. measured by enzyme-linked...
Purpose . To evaluate angiographic findings of peripheral retina vasculature in retinopathy prematurity (ROP) neonates who received intravitreal conbercept (IVC) or ranibizumab (IVR). Methods Fluorescein angiography (FA) were retrospectively evaluated for ROP IVC IVR. Outcome measures included avascular zone, vascular leakage, blunting, loops, dilatation, arteriovenous shunt, and capillary dropout. Results Fifty-four eyes (28 patients) with included. Twenty-nine (15 IVC, 25 (13 For infants...
Endophthalmitis occurring in silicone oil-filled eyes is a very rare occurrence, with reported incidence rates ranging between 0.07% and 0.039%. Traditional methods of management infectious endophthalmitis include the removal oil, washout vitreous cavity, administration intravitreal antibiotics, re-injection oil.
To describe the long-term effect of scleral buckling (SB) surgery for stage 4A retinopathy prematurity (ROP). A retrospective chart review was conducted patients with a diagnosis ROP who underwent SB between October 2010 and 2021. Basic data were collected from patient charts, including gender, birth weight, gestational age at birth, disease stage, presence plus disease, preoperative treatment [laser photocoagulation, intravitreal anti-vascular endothelial growth factor (VEGF) agent therapy,...
Purpose: As common retinopathy is observed in low-birth infants, the characteristics of ROP twins are worth exploring. The present study tried to demonstrate risk factors treatment for prematurity (ROP) both diagnosed with ROP. Methods: A retrospective, institution-based cohort 62 premature twin pairs a mean gestational age (GA) younger than 35 weeks and birth weight (BW) lower 2500 g. Only infants follow-up period longer 6 months complete records were included. demographic data,...
Abstract Background To evaluate the effect of room air and sulfur hexafluoride (SF6) gas in idiopathic macular hole(MH)surgery. Methods Retrospective, interventional, comparative study. 238 eyes with hole that underwent pars plana vitrectomy, internal limiting membrane peeling, fluid-air exchange, 20% SF6 (SF6 group:125 eyes) or tamponade (air group: 113 were reviewed. The primary outcome measure was closure rate surgery. Results baseline characteristics group comparable except for size...
To demonstrate that the demographic and treatment characteristics of retinopathy prematurity (ROP) eyes showed different types hyperfluorescence in fluorescein angiography (FA) initially treated with anti-vascular endothelial growth factor (VEGF) agents. A consecutive case series ROP anti-VEGF agents was retrospectively studied. All patients underwent FA examinations at least 6 months later after treatment. The or without were analyzed. divided into three groups, including vascular leakage,...
Objective To evaluate the application of a mobile platform-based system in management fundus disease outpatient settings. Methods In departments disease,premature babies requiring eye examination under general anesthesia and adults intraocular surgery were enrolled as subjects. According to existing clinical practices,we developed that met requirements practices optimized management. Based on FileMaker database,the tablet computers used platform could also be run iPad PC terminals.Results...
Objective To observe the surgical effects of scleral buckling and vitrectomy for familial exudative vitreoretinopathy (FEVR). Methods 34 eyes 27 patients with FEVR who underwent either or were enrolled in this study. There are stage 2B 2 (5.88%), 3B 7 (20.59%), 4A 1 eye (2.94%), 4B 16 (47.06%), 5 8 (23.53%). associated rhegmatogenous retinal detachment. The approaches had been chosen according to disease stage, severity, extent morphology proliferative membrane. 13 (stage eyes, 4...
Objective To evaluate the efficacy of vitreous surgery for patients with vitreomacular traction syndrome. Methods Of 30 (30 eyes) who underwent vitrectomy syndrome were retrospectively analyzed. Results Vitreomacular was released successfully, and a better visual acuity obtained in 20 eyes. Mean macular thickness decreased by 267μ m postoperatively. The eyes showed statistically significant improvement central (P <0.05). Optical coherence tomography (OCT) fluorescein fundus angiography (FFA)...