A5043447204- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Neuroscience and Neuropharmacology Research
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Ion channel regulation and function
- Otitis Media and Relapsing Polychondritis
- Allergic Rhinitis and Sensitization
- Air Quality and Health Impacts
- Circadian rhythm and melatonin
- Inflammasome and immune disorders
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Photoreceptor and optogenetics research
- Autoimmune and Inflammatory Disorders Research
- Corneal surgery and disorders
- Advanced Nanomaterials in Catalysis
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Nicotinic Acetylcholine Receptors Study
- interferon and immune responses
- Diet, Metabolism, and Disease
- Climate Change and Health Impacts
- Nanoplatforms for cancer theranostics
Second Hospital of Anhui Medical University
2016-2025
Anhui Medical University
2016-2025
Shanghai Advanced Research Institute
2024
Chinese Academy of Sciences
2024
Dalian University of Technology
2021
Ophthalmology Associates (United States)
2016
Ministry of Education of the People's Republic of China
2015
Chongqing Medical University
2009-2012
The Affiliated Yongchuan Hospital of Chongqing Medical University
2009-2012
Oregon Health & Science University
1991-2010
1. A tissue slice containing a section of striatum was cut obliquely from rat brain so as to preserve adjacent cortex and pallidum. Intracellular recordings were made 368 neurones, using either conventional or tight-seal configurations. 2. Two types neurone distinguished electrophysiologically. Principal cells (96%) had very negative resting potentials (-89 mV) low input resistance at the membrane potential (39 M omega): conductance (10 nS -65 increased within tens milliseconds after onset...
To identify susceptibility loci for Behçet's disease (BD) and elucidate their functional role.A genome-wide association study (GWAS) studies were conducted. A total of 149 patients 951 controls enrolled in the initial GWAS, 554 1,159 replication study. Real-time polymerase chain reaction, luciferase reporter assay, enzyme-linked immunosorbent assay performed.Our GWAS identified a locus around STAT4 (single-nucleotide polymorphisms [SNPs] rs7574070, rs7572482, rs897200; P = 3.36 × 10(-7) to...
Intracellular recordings were made from neurons of rat lateral amygdala, nucleus accumbens, and striatum in vitro. Synaptic potentials mediated by gamma-aminobutyric acid excitatory amino acids isolated pharmacologically using receptor antagonists, their amplitudes used as a measure transmitter release. Muscarine acetylcholine inhibited the release both acids, but measurements dissociation equilibrium constants for antagonists pirenzepine,...
To our knowledge, a set of well-defined diagnostic criteria is not yet developed for the diagnosis Vogt-Koyanagi-Harada (VKH) disease. develop and evaluate VKH disease using data from Chinese patients. This case-control study reviewed medical records patients tertiary referral center between October 2011 2016. Data 634 with 623 non-VKH uveitis southern China were used to Diagnostic Criteria Disease (DCV). an additional group 537 definite 525 northern criteria. Sensitivity, specificity,...
Oxidative stress and the resultant hyperpermeability play a vital role in pathogenesis of diabetic retinopathy (DR). Poldip2 has been implicated H2O2 production, but effects capsaicin on poldip2 have not reported.Diabetic Sprague-Dawley (SD) rats induced with STZ were treated or AAV9-poldip2-shRNA, human retinal microvascular endothelial cells (HRMECs) siRNA.Current data indicated that expression PPARγ, poldip2, Nox4, VCAM-1, HIF-1α, VEGF increased rat retinas DR HRMECs high glucose. The...
Inflammatory diseases present with dysregulated inflammatory reactions and oxidative stress, resulting in heavy health-associated economic burden to society. Current mainstream therapies, including traditional therapies such as steroids, non-steroidal anti-inflammatory drugs (NSAIDs) immunosuppressants, well novel biological strategies cytokine intracellular signal inhibitors, cannot cure always cause a series of unexpected adverse effects. Natural products (NPs), which are complex chemical...
Objectives To provide an overview and in-depth analysis of temporal trends in prevalence musculoskeletal (MSK) disorders women childbearing age (WCBA) at global, regional national levels over the last 30 years, with a special focus on their associations age, period birth cohort. Methods Estimates 95% uncertainty intervals (UIs) for MSK WCBA were extracted from Global Burden Diseases, Injuries Risk Factors Study 2019. An age-period-cohort model was adopted to estimate overall annual...
Abstract Diabetic retinopathy (DR) is the most prevalent type of retinal vasculopathy and widespread cause preventable blindness in adults. Excessive increases reactive oxygen species (ROS) vascular endothelial growth factor are major initiators drivers DR progression, respectively. However, current treatment options remain limited, particularly for early DR. Nanotechnology‐mediated antioxidant strategies gaining increasing popularity to treat ocular diseases. Quercetin has excellent ROS...
1. Repetitive stimulation of guinea‐pig hypogastric nerves elicited, in addition to the fast cholinergic excitatory potential, a slow depolarization lasting for seconds minutes neurones isolated inferior mesenteric ganglion. 2. The which could be elicited at frequency as low 1‐2 Hz several was not blocked by antagonists, but eliminated Ca2+ solution; it termed henceforth non‐cholinergic potential. 3. When membrane potential manually clamped, associated with three types resistance change: an...
<h3>Purpose</h3> IL-23 has been shown to be involved in the pathogenesis of Behcet9s disease (BD) through promoting IL-17 production. This study examined whether <i>IL-23R</i> polymorphisms were associated with susceptibility this a Chinese Han population. <h3>Methods</h3> Four single-nucleotide (SNP), rs7517847, rs11209032, rs 1343151 and rs17375018 genotyped 338 BD patients 407 age, sex ethnically matched healthy controls using PCR restriction fragment length polymorphism assay....
Purpose: Apigenin is a natural small molecule compound widely present in various vegetables and fruits. Recently, was reported to inhibit lipopolysaccharide (LPS)-simulated microglial proinflammatory activation. Considering the important role of microglia retinal disorders, we wonder whether could exert therapeutic effect on experimental autoimmune uveitis (EAU) through reprogramming beneficial subtype. Methods: EAU induced C57BL/6J mice by immunization with interphotoreceptor...
1. Whole‐cell recordings were made from 390 neurons of the suprachiasmatic nucleus (SCN) in horizontal brain slices during different portions circadian day. The locomotor activity rats was measured prior to preparation insure that each rat entrained a 12 h‐12 h light‐dark cycle. 2. mean input conductance 42% higher (1.58 nS) recorded near subjective dawn than those (1.11 dusk. current required hold at ‐60 mV also showed variation with peak middle day and nadir night. Analysis variations...
To evaluate the effect of diabetic retinopathy (DR) status or severity on all-cause and cause-specific mortality among older adults in United States using most recent National Health Nutrition Examination Survey (NHANES) follow-up data. The DR was graded according to Early Treatment Diabetic Retinopathy Study (ETDRS) grading scale. Multiple covariate-adjusted Cox proportional hazards regression models, Fine Gray competing risk propensity score matching (PSM) methods were used assess...
To explore temporal trends and determine driving factors of age-related macular degeneration (AMD) burden in older adults aged 60-89 years at global, regional national levels from 1990 to 2019.
Traffic-related air pollution especially in highly socioeconomically developed megacity is usually considered as a severe problem leading to inevitable adverse health outcomes. This study aimed investigate the associations between traffic-related pollutants with risk of dry eye disease (DED) outpatient visits (Guangzhou) along subtropical coast South China. Daily data on DED and environmental variables from 1 January 2014 31 December 2020 Guangzhou were obtained. A time-series using...
Globally, uveitis is a collection of intraocular inflammatory disorders that affect mainly the uvea, resulting in irreversible blindness and heavy socioeconomic burden. Excessive autoimmune inflammation oxidative stress are major drivers contribute to initiation progression uveitis. Nevertheless, current therapeutic methods for limited accompanied by several serious adverse effects. Recently, nanotechnology-based antioxidant strategies have provided novel options treatment ocular diseases....