A5053805883- Parathyroid Disorders and Treatments
- Fibroblast Growth Factor Research
- Complement system in diseases
- Connective tissue disorders research
- Platelet Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Inflammasome and immune disorders
- Chronic Kidney Disease and Diabetes
- Corneal Surgery and Treatments
- Kawasaki Disease and Coronary Complications
- Autoimmune and Inflammatory Disorders Research
- Glaucoma and retinal disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ocular Diseases and Behçet’s Syndrome
- Corneal surgery and disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- Blood Coagulation and Thrombosis Mechanisms
- Retinal Imaging and Analysis
- Connexins and lens biology
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Genetic Syndromes and Imprinting
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders
University of Colorado Denver
2021-2024
Suzhou Municipal Hospital
2021
Nanjing Medical University
2020-2021
Zhongda Hospital Southeast University
2020-2021
University of Colorado Anschutz Medical Campus
2021
Jinan University
2014-2020
ORCID
2020
Soochow University
2011
First Affiliated Hospital of Soochow University
2011
To our knowledge, a set of well-defined diagnostic criteria is not yet developed for the diagnosis Vogt-Koyanagi-Harada (VKH) disease. develop and evaluate VKH disease using data from Chinese patients. This case-control study reviewed medical records patients tertiary referral center between October 2011 2016. Data 634 with 623 non-VKH uveitis southern China were used to Diagnostic Criteria Disease (DCV). an additional group 537 definite 525 northern criteria. Sensitivity, specificity,...
Patients with chronic kidney disease (CKD) often exhibit associated endothelial dysfunction and inflammation. Systemic inflammation may contribute to the accelerated thrombosis observed in CKD patients. In this study, we assessed relationships among dysfunction, a disintegrin-like metalloprotease thrombospondin type 1 repeats 13 (ADAMTS13) activity levels of inflammatory cytokines patients were classified into three groups: The glomerulonephritis group (CGN; n=31), idiopathic nephritic...
Unchecked inflammation can result in severe diseases with high mortality, such as macrophage activation syndrome (MAS). MAS and associated cytokine storms have been observed COVID-19 patients exhibiting systemic hyperinflammation. Interleukin-18 (IL-18), a proinflammatory belonging to the IL-1 family, is elevated both patients, its level known correlate severity of symptoms. IL-18 binds specific receptor 5 (IL-1R5, also alpha chain), leading recruitment coreceptor, 7 (IL-1R7, beta chain)....
Introduction Interleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is key mediator ofautoinflammatory diseases associated with development of macrophage activation syndrome (MAS).High levels IL-18 correlate MAS and COVID-19 severity mortality, particularly in COVID-19patients MAS. As an inflammation inducer, binds its receptor Receptor 5 (IL-1R5), leadingto recruitment co-receptor, 7 (IL-1R7). This heterotrimeric complex subsequentlyinitiates downstream signaling,...
Cardiovascular disease (CVD) is the leading cause of death in haemodialysis (HD) patients. Vascular calcification (VC) dramatically accelerated and strongly associated with CVD events mortality HD VC coexists osteoporosis many studies. Fibroblast growth factor 21 (FGF21) which known as an adipocytokine a new hypoglycemic strategy inversely related to bone mineral density.To evaluate contribution FGF21 patients, we detected circulating levels measured whole thoracic aorta scores (TACS) 3...
Abstract Background The goal was to characterize retinal vasculature by quantitative analysis of arteriole-to-venule (A/V) ratio and vessel density in fundus photos taken with the PanOptic iExaminer System. Methods ophthalmoscope equipped a smartphone used acquire centered on optic nerve head. Two total 19 eyes from 10 subjects were imaged. Retinal vessels analyzed obtain A/V ratio. In addition, tree extracted using deep learning U-NET, processed percentage pixels within over entire image....
Abstract Inflammation is considered an important mechanism in the development of diabetes mellitus (DM) and persists for a long time before occurrence diabetic nephropathy (DN). Many studies have demonstrated that decrease endothelial glycocalyx (EG) negatively correlated with proteinuria. To elucidate whether EG damage induced by inflammasomes DM patients leads to microalbuminuria (MA) accelerates progression DN, this study screened 300 diagnosed patients. Finally, 70 type 2 were invited...
Abstract Introduction Osteoporosis is one of the important bone abnormalities in chronic kidney disease-mineral and disorder (CKD-MBD) still lacks a sensitive biomarker to diagnose. Fibroblast growth factor 21 (FGF21) can stimulate loss patients with diabetes increase CKD patients. In this study, we investigated whether FGF21 could serve as predict osteoporosis haemodialysis cohort. Methods We recorded demographic information, biochemical data, serum FGF23 levels measured CT attenuation...
Genetic variations within the paired box gene 6 (PAX6) are associated with congenital aniridia.To detect genetic defects in a Chinese twin family aniridia and nystagmus, exons of PAX6 were amplified by polymerase chain reaction (PCR), sequenced compared reference database.Six members from three generations included study.The twins' father presented aniridia, nystagmus cataract at birth, while twins nystagmus.A novel mutation c.888 insA exon 10 was identified all affected individuals.This...
Abstract Background: Cardiovascular disease (CVD) is the leading cause of death in haemodialysis (HD) patients. Vascular calcification (VC) dramatically accelerated and strongly associated with CVD events mortality HD VC coexists osteoporosis many studies. Fibroblast growth factor 21 (FGF21) as an adipocytokines a new hypoglycemic strategy inversely related to bone mineral density . Methods: To evaluate contribution FGF21 patients, we preliminary sreened 802 patients two large centers China....
Background Previous studies demonstrated that the transforming growth factor beta induced (TGFβⅠ) gene is most common disease-causing for corneal dystrophy.However,if DNA variant associated with phenotype unclear.Objective This study was to identify clinical features and molecular genetics of a Chinese family Avellino dystrophy (ACD) analyze association between TGFβⅠ mutation phenotype.Methods complied Helsinki Declaration approved by Ethic Commission Shenzhen Eye Hospital.Informed consent...
Abstract Background and Aims Cardiovascular disease (CVD) is the leading cause of death in hemodialysis (HD) patients. Vascular calcification (VC) dramatically accelerated strongly associated with CVD events mortality HD This study aimed to achieve 4 objectives using a population-based retrospective cohort patients: (1)quantify correlation between FGF21 VC; (2)determine whether novel risk factor for (3)examine predictive effect on (4)explore underlying mechanism promoting VC, especially...
Abstract Background and Aims The global diabetes mellitus (DM) prevalence in 2019 is estimated to be 9.3%. Approximately 20% 40% of patients with DM develop diabetic nephropathy (DN). DN the leading cause end stage renal disease (ESRD). Inflammation considered an important mechanism development persists for a long time before occurrence DN. Many studies demonstrated that decrease endothelium glycocalyx (EG) was negatively correlated proteinuria. Whether EG damage induced by inflammasome...