A5045359066- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Ophthalmology and Eye Disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Corneal Surgery and Treatments
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Ion channel regulation and function
- Lymphatic System and Diseases
- Ocular Disorders and Treatments
- Urological Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Neurological diseases and metabolism
- Herpesvirus Infections and Treatments
- Autoimmune and Inflammatory Disorders
- Concrete Properties and Behavior
- Concrete and Cement Materials Research
- Collaboration in agile enterprises
- Quality and Supply Management
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2014-2025
Ningxia Medical University
2008-2023
Ningxia Hui Autonomous Region Peoples Hospital
2014-2023
Northwest Minzu University
2016-2020
Northwest University
2018-2020
China University of Mining and Technology
2019
Jiangsu Province Hospital
2017
Nanjing Medical University
2017
Chongqing Medical University
2012
The Affiliated Yongchuan Hospital of Chongqing Medical University
2012
To our knowledge, a set of well-defined diagnostic criteria is not yet developed for the diagnosis Vogt-Koyanagi-Harada (VKH) disease. develop and evaluate VKH disease using data from Chinese patients. This case-control study reviewed medical records patients tertiary referral center between October 2011 2016. Data 634 with 623 non-VKH uveitis southern China were used to Diagnostic Criteria Disease (DCV). an additional group 537 definite 525 northern criteria. Sensitivity, specificity,...
Significance Because preschool children encounter fewer risks from environmental pressures, we propose that the condition of early-onset high myopia (EOHM) is driven by a genetic predisposition more than factors. In this study, recruited 18 familial trios to decipher using whole-exome sequencing. We identified cluster unique genes linked EOHM, as well mutations in reported genes. Notably, showed both rare inherited and de novo significantly contributed EOHM. Expression profiling ocular...
BackgroundMyopia is a good model for understanding the interaction between genetics and environmental stimuli. Here we dissect biological processes affecting myopia progression.MethodsHuman Genetic Analyses: (1) gene set analysis (GSA) of new genome wide association study (GWAS) data 593 individuals with high (refraction ≤ -6 diopters [D]); (2) over-representation (ORA) 196 genes de novo mutations, identified by whole sequencing 45 high-myopia trio families, (3) ORA 284 previously reported...
Objective To compare different doses and dosing regimens of RC28-E, a novel bispecific antibody that simultaneously binds vascular endothelial growth factor-A (VEGF-A) fibroblast factor-2 (FGF-2), with conbercept in patients diabetic macular edema (DME). Design Prospective, randomised, active comparator-controlled, open-label, multicentre, phase 2 clinical trial.cente Participants The trial enrolled aged 18 years or older centre-involving DME, best-corrected visual acuity (BCVA) 73 to 24...
Purpose: High myopia (HM) is defined as a refractive error worse than −6.00 diopter (D). This study aims to update the phenotypic and genotypic landscape of nonsyndromic HM establish biological link between traits genetic deficiencies. Methods: A cross-sectional involving 731 participants varying in error, axial length (AL), age, myopic retinopathy, visual impairment. The were analyzed by four ophthalmologists while mutational screening was performed eight autosomal causative genes. Finally,...
The aim of this study was to investigate the genetic basis and pathogenic mechanism variable maculopathies, ranging from mild photoreceptor degeneration central areolar choroidal dystrophy, in a five-generation family.Clinical characterizations, whole-exome sequencing, genome-wide linkage analysis were carried out on family. Zebrafish models used pathogenesis GUCA1A mutations.A novel mutation, p.R120L, identified family predicted alter tertiary structure guanylyl cyclase-activating protein...
Ocular coloboma is a developmental structural defect of the eye that often occurs as complex ocular anomalies. However, its genetic etiology remains largely unexplored. Here we report identification mutation (c.331C>T, p.R111C) in IPO13 gene consanguineous family with coloboma, microphthalmia, and cataract by combination whole-exome sequencing homozygosity mapping. encodes an importin-B protein has been proven to be associated pathogenesis microphthalmia. We found Ipo13 was expressed cornea,...
Abstract Clinical studies have demonstrated an association between high myopia (HM) and neuropsychiatric disorders; however, the underlying mechanism of is not clear. We used whole exome sequencing (WES) in combination with Genetic Variants Classification Criteria Guidelines published by American College Medical Genetics (ACMG) bioinformatics analysis to clarify interrelationship candidate genes. Causative genes for ocular diseases (45.38%) followed disorders (22.69%) accounted highest...
To assess the visual outcomes and possible risk factors associated with axis alignment rotational stability after implantation of Toric implantable collamer lens (TICL) for correction high myopic astigmatism.In this prospective, nonrandomized clinical study, 54 consecutive eyes 29 patients astigmatism received TICL implantation. evaluate postoperative deviation from intended axis, a digital anterior segment photograph was taken. The ultrasound biomicroscopy(UBM) used to observe...
Purpose Recent genome-wide association studies (GWAS) have verified eight genetic loci that were significantly associated with primary angle–closure glaucoma (PACG). The present study investigated whether these variants are the ocular biometric parameters of anterior chamber depth (ACD) and axial length (AL) in a northern Chinese population, as well there differences markers our cohort based on ethnicity. Methods A case-control 500 patients 720 controls was undertaken. All individuals...
To assess the effect of myopia on thickness retinal nerve fiber layer (RNFL) measured by 3D optical coherence tomography (3D-OCT) in a group nonglaucomatous Chinese subjects.Two hundred and fifty-eight eyes 258 healthy myopic individuals were recruited four groups classified according to their spherical equivalent (SE): low (n=42, -0.5D<SE<-3.0D), moderate (n=120, -3.0D≤SE<-6.0D), high (n=58, -6.0D≤SE<-8.0D) extreme (n=38, SE≥-8.0D). The RNFL profile including superior, nasal, inferior...
Purpose: The associations between genetic variants located in CFH, CFB, ARMS2 and HTRA1 the risk of age-related macular degeneration (AMD) a northern Chinese population were investigated.Methods: A case-control association study 150 AMD patients 145 ethnicity- gender-matched controls recruited. Genomic DNA was prepared from peripheral blood after participants underwent comprehensive eye examinations. All individuals genotyped for eight single nucleotide polymorphisms (SNPs) four specific...
To describe the clinical characteristics with genetic lesions in a Chinese family Crouzon syndrome.All five patients from this were included and received comprehensive ophthalmic systemic examinations. Direct sequencing of FGFR2 gene was employed for mutation identification. Crystal structure analysis applied to analyze structural changes associated substitution.All presented typical features, including short stature, craniosynostosis, mandibular prognathism, shallow orbits proptosis,...
High myopia (HM) is one of the leading causes visual impairment worldwide. In order to expand gene spectrum in Chinese population, we investigated genetic mutations a cohort 27 families with HM from Northwest China by using whole-exome sequencing (WES). Genetic variations were filtered bioinformatics tools and cosegregation analysis. A total 201 candidate detected, 139 cosegregated disease families. Multistep analysis revealed four missense variants unrelated families, including...
The membrane frizzled-related protein (MFRP) gene is involved in axial length (AL) regulation and MFRP mutations cause nanophthalmos; also, the hepatocyte growth factor (HGF) reported to result morphologic changes of anterior segment abnormal aqueous that increases risk primary angle-closure glaucoma (PACG), while zinc ring finger 3 (ZNRF3) associated with AL. present study investigated association single nucleotide polymorphisms (SNPs) ZNRF3, HGF PACG a northern Chinese population, as well...
Purpose: To screen VSX1 gene sequence variations and describe the clinical features of families with keratoconus (KC) from northwest China. Methods: We screened data 37 including probands diagnosed KC Ningxia Eye Hospital (China). was by targeted next-generation sequencing (NGS) verified Sanger sequencing. In silico analysis Mutation Taster, MutationAssessor, PROVEAN, MetaLR, FATHMM, M-CAP, FATHMM-XF_coding DANN performed to identify pathogenicity as well conserved amino acid implemented...