A5100327677- Photonic and Optical Devices
- Photonic Crystal and Fiber Optics
- Advanced Fiber Optic Sensors
- Enzyme Production and Characterization
- Electron and X-Ray Spectroscopy Techniques
- Sulfur Compounds in Biology
- Microbial Metabolites in Food Biotechnology
- Advanced Electron Microscopy Techniques and Applications
- Genetic and Kidney Cyst Diseases
- Advanced Photonic Communication Systems
- Advanced Fiber Laser Technologies
- Hedgehog Signaling Pathway Studies
- Optical Network Technologies
- Acupuncture Treatment Research Studies
- Pancreatic function and diabetes
- Microtubule and mitosis dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Advanced Measurement and Detection Methods
- Rock Mechanics and Modeling
- Spectroscopy and Chemometric Analyses
- Biosensors and Analytical Detection
- Terahertz technology and applications
- Welding Techniques and Residual Stresses
- Nanoparticles: synthesis and applications
- Surface and Thin Film Phenomena
Centrum für Integrierte Onkologie
2024
University Hospital Cologne
2023-2024
University of Cologne
2023-2024
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2024
Institute of Physics
2024
Chinese Academy of Sciences
2024
Jilin Vocational College of Industry and Technology
2024
Shanghai Jiao Tong University
2010-2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
Hefei Institutes of Physical Science
2023
Objective To compare different doses and dosing regimens of RC28-E, a novel bispecific antibody that simultaneously binds vascular endothelial growth factor-A (VEGF-A) fibroblast factor-2 (FGF-2), with conbercept in patients diabetic macular edema (DME). Design Prospective, randomised, active comparator-controlled, open-label, multicentre, phase 2 clinical trial.cente Participants The trial enrolled aged 18 years or older centre-involving DME, best-corrected visual acuity (BCVA) 73 to 24...
So far, how the animals evade environmental nanomaterials is still largely unclear. In this study, we employed in vivo assay system of Caenorhabditis elegans to investigate aversive behavior nematodes graphene oxide (GO) and underlying neuronal basis.In model, detected significant GO at concentrations more than 50 mg/L. Loss-of-function mutation nlg-1 encoding a neuroligin with function connecting pre- post-synaptic neurons suppressed GO. Moreover, based on neuron-specific activity assay,...
Obesity, along with type 2 diabetes mellitus (T2DM), is a major contributor to hypertension. The renin-angiotensin-aldosterone system involved in the occurrence of and However, mechanism by which obesity related T2DM induced hypertension unclear. In this study, we observed that blood pressure serum renin content were increased patients Hydrogen sulfide (H2S), as an endogenous bioactive molecule, has been shown be vasodilator. Db/db mice, characterized T2DM, juxtaglomerular (JG) cells, line...
Abstract: The calcium‐sensing receptor (CaR) is a G protein‐coupled receptor. CaR stimulation elicits phospholipase C‐mediated inositol triphosphate formation, leading to an elevation in the level of intracellular calcium released from endoplasmic reticulum (ER). Depletion ER Ca 2+ leads stress, which thought induce apoptosis. Intracellular overload‐induced apoptosis cardiac myocytes during hypoxia–reoxygenation (H/Re) has been demonstrated. However, links between CaR, stress and H/Re are...
The volatiles in coffee play an important part the overall flavor profile. In this study, GC–TOF/MS and GC×GC–TOF/MS were used to detect volatile organic compounds (VOCs) samples of three different brands at states (bean, powder, brew). differences between two methods characterizing VOCs analyzed using Venn diagram PCA (principal component analysis). aroma-contributing further compared analyzed. results venn diagrams showed that most existed 2–3 kinds coffee. detected by could distinguish...
Hydrogen sulfide (H2S), as a gasotransmitter, is involved in various pathophysiological processes. Diabetic cardiomyopathy (DCM) major complication of diabetes mellitus (DM), which leads to structural and functional abnormalities the myocardium eventually causes heart failure (HF). Systolic diastolic dysfunction are fundamental features failure. SERCA2a, key enzyme for calcium transport endoplasmic reticulum (ER), affects process myocardial relaxation contraction. H2S can protect cardiac...
We present an ultrafast pulse waveform measurement system based on electro-optic sampling technique at 1560 nm and prepare LiTaO3-based modulators with a coplanar waveguide structure. The transmission reflection characteristics of electrical pulses terminated open circuit resistor are investigated by analyzing the corresponding time-domain waveforms. measure output 100 GHz photodiode obtained rise times impulse step responses 2.5 3.4 ps, respectively.
Cell-envelope proteinases (CEPs) can improve the texture and organoleptic characteristics of dairy products, may also cause release bioactive peptides, which contribute to improving host’s health. Thus, CEPs with high activity produced by L. plantarum has great potential in development functional products.A single factor experiment was used investigate effects prebiotics (inulin, stachyose, isomaltooligosaccharide, xylooligosaccharides, galactooligosaccharides fructooligosaccharides),...
The primary cilium plays important roles in regulating cell differentiation, signal transduction, and tissue organization. Dysfunction of the can lead to ciliopathies cancer. formation organization are highly associated with polarity proteins, such as apical protein CRB3. However, molecular mechanisms by which CRB3 regulates ciliogenesis location remain unknown. Here, we show that CRB3, a navigator, vesicle trafficking γ-tubulin ring complex (γTuRC) assembly during cilium-related Hh Wnt...
Abstract In the present study, a simple and sensitive photo‐induced chemiluminescence (CL) method for quantitation of reducing sugars, including fructose, glucose, sucrose lactose, was developed. This based on on‐line photocatalytic reaction using home‐made photoreactor consisting PTEF tube helically coiling around high‐pressure mercury UV lamp. Reducing sugars were detected by direct CL emission resulting from between photoproducts luminol. To maximize signal intensity, effects irradiation...
Using Yam starch as raw material, the fermentation technology of Single Cell Protein (SCP) was optimized through by active dry yeast single factor and orthogonal test in this study. The optimal conditions were showed followed: 30 mL medium volume 250 flask, inoculum size17%, time 69 h, pH 5.0. Under these conditions, production SCP reached 241.54±0.15 (g wet weight/100 g Dry starch.
BRCA1 is a tumor suppressor that has been found to be involved DNA synthesis during cell replication. In recent study, the single nucleotide polymorphism (SNP), rs799917, in was associated with development and progression of various types tumor. present association between rs799917 susceptibility lung cancer evaluated Han Chinese population Liaoning Province China. The genotypes (C/C, C/T T/T) were analyzed using TaqMan quantitative PCR 682 patients 694 healthy controls, results Student's...
A hybrid wavelength division multiple access (WDMA)/optical code multiplexing (OCDM) system is proposed, where the optical not same as address of every network unit (ONU); rather, a virtual fiber passive (PON).To our knowledge, this first report analyzing single encoder/decoder with corresponding being exploited to encode/decode signals simultaneously.This enables OCDM become transparent ONU so that existing (WDM) PON can be upgraded.Thus, redesigning line terminal and easily accomplished,...
Aiming at some long ore passes with severe damages and extensive collapses, we describe an optimal measure to plug a local area of pass in order maintain the capacity continued use. This paper, taking new for extensively collapsed non-empty condition as breakthrough, builds structure-plugging system based on effect, suspension arch span-reducing effect. Meanwhile, key plugging technology has been integrated which includes stability evaluation method structure, controlled drilling casing...
Classification of live and dead human ovarian cancer cells (SKOV3) is an important task in biomedicine research. Fluorescence the most common technique to distinguish cells. However, it requires physical contact cells, which affects appearance their features a certain degree. There urgent need develop novel non-invasive technology for this application. This paper proposes first hyperspectral image (HSI) based system address issue. A microscopic imaging built capture cell images. Then...
Background.Cell-envelope proteinases (CEPs) can improve the texture and organoleptic characteristics of dairy products, may also cause release bioactive peptides, which contribute to improving host's health.Thus, CEPs with high activity produced by L. plantarum has great potential in development functional products.Methods.A single factor experiment was used investigate effects prebiotics (inulin, stachyose, isomaltooligosaccharide, xylooligosaccharides, galactooligosaccharides...
We proposed a Upstream Multi-Wavelength Shared PON using tunable self-seeding FP-LD at ONU. The fiber laser performances are experimentally investigated. paper also for the first time studies effect of channel switch latency on DBA with IPACT scheme.
Despite the considerable success of Bregman proximal-type algorithms, such as mirror descent, in machine learning, a critical question remains: Can existing stationarity measures, often based on divergence, reliably distinguish between stationary and non-stationary points? In this paper, we present groundbreaking finding: All measures necessarily imply existence spurious points. We further establish an algorithmic independent hardness result: algorithms are unable to escape from point finite...