A5102939562- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Polyamine Metabolism and Applications
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- MicroRNA in disease regulation
- Maternal and fetal healthcare
- Extracellular vesicles in disease
- Cannabis and Cannabinoid Research
- Heme Oxygenase-1 and Carbon Monoxide
- Exercise and Physiological Responses
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hearing, Cochlea, Tinnitus, Genetics
- Genetics and Neurodevelopmental Disorders
- Bone Metabolism and Diseases
- FOXO transcription factor regulation
- RNA regulation and disease
- Sulfur Compounds in Biology
- Genomic variations and chromosomal abnormalities
- Ectopic Pregnancy Diagnosis and Management
- Oral health in cancer treatment
- Connexins and lens biology
- Apelin-related biomedical research
Sichuan University
2014-2024
West China Second University Hospital of Sichuan University
2014-2024
Hangzhou Children's Hospital
2022
Nantong University
2021
Hospital of Hebei Province
2021
Third Hospital of Hebei Medical University
2021
Hebei Medical University
2021
Beijing Tian Tan Hospital
2020
Capital Medical University
2020
Weatherford College
2019
Sarcopenia, characterized by reduced muscle function as well mass, has been a public health problem with increasing prevalence. It might result from aging, injury, hormone imbalance and other catabolic conditions. Recently, exosomes were considered to regulate regeneration protein synthesis. In order confirm the effect of BMSC-derived (BMSC-Exos) on muscle, dexamethasone-induced atrophy was built both in vitro vivo . present research, BMSC-Exos attenuated decrease myotube diameter induced...
Myocardial infarction (MI) is associated with a high mortality rate, which attributed to the effects of myocyte loss that occurs as result ischemia-induced cell death. Very few therapies can effectively prevent or delay ischemia. Polyamines (PAs) are polycations required for growth and division, their use may loss. The aim this study was investigate relationship between hypoxia/ischemia (H/I)-induced apoptosis PA metabolism ability spermine limit H/I injury in cardiomyocytes by blocking...
Abstract Background The belief that genetics plays a major role in the pathogenesis of congenital heart defects (CHD) has grown popular among clinicians. Although some studies have focused on genetic testing foetuses with CHD China, genotype–phenotype relationship not yet been fully established, and hotspot copy number variations (CNVs) related to Chinese population are still unclear. This cohort study aimed assess prevalence chromosomal abnormalities different types CHD. Results In 200...
Eupatilin (5,7‐dihydroxy‐3′,4′,6‐trimethoxyflavone) is a natural active substance found in génépi group plants, and its pharmacological activities has been proven to be useful the treatment of various cancers. However, whether eupatilin demonstrates anti‐cancer activity cervical cancer still under evaluation. To clarify this, cell lines nude mouse model were used this study. The results indicated that could inhibit occurrence both vivo vitro. Cervical (C4‐1, HeLa, Caski, Siha) Ect1/E6E7...
This meta-analysis aims to elucidate the role of probiotics in regulating blood lipid profiles adults with overweight or obesity. The Pubmed, Cochrane Library, Scopus and Web Science were used search for relevant randomized controlled trials (RCTs) published before August 2021. effects probiotic intervention assessed by total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C) high-density (HDL-C) levels. outcome data synthesized using standardized mean differences (SMDs)....
Pulmonary vascular remodeling is a significant pathological feature of hypoxia-induced pulmonary hypertension (HPH), while artery smooth muscle cell (PASMC) proliferation plays leading role in remodeling. Spermine (Sp), polyamine, critical periodic and apoptosis. The present study was conducted to observe the association between PASMC polyamine metabolism, explore effects exogenous Sp on poliferation related mechanisms. In study, PASMCs were cultured with cobalt chloride (CoCl2) establish...
Other SectionsABSTRACTINTRODUCTIONRESULTSDISCUSSIONMATERIALS AND METHODSACKNOWLEDGEMENTSSupplementary InformationFIGURESREFERENCES
Wound complications are a major source of morbidity after cesarean section (CS) and contribute to increased risks in subsequent pregnancies. In the present study, we aim investigate wound healing potential kind oligopeptide compound, mainly derived from marine fish peptides (MFPs), rats CS by biomechanical, biochemical, histological methods.Eighty-four pregnant Sprague-Dawleyrats were randomly assigned four groups, namely control group 1.1, 2.2, 4.4 mg/kg MFP respectively. The MFPs or normal...
Background: The cystic fibrosis transmembrane conductance regulator (CFTR) and nuclear factor κB (NF-κB) signalling pathways are currently regarded as co-regulators of the occurrence cervical cancer. However, detailed mechanism CFTR- NF-κB-mediated effects in cancer remains to be elucidated. This study aimed investigate by which CFTR NF-κB influence development Patients Methods: ΔF508 mutation promoter methylation were detected tissue samples. p65 IκBα protein levels tested HeLa cells with...
Reactive astrogliosis is a key hallmark of inflammatory responses in the pathogenesis brain injury, including Parkinson’s disease (PD), but its role and regulatory mechanisms are not fully understood. Pannexin 1 (Panx 1) membrane channel that mediates substance release many neurodegenerative diseases. However, astrocyte Panx regulation PD-like neuroinflammation remains elusive. Here, we characterized expression isolated primary astrocytes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...
Abstract This study explored the mechanisms underlying recovery of myocardial protection from ischemic post‐conditioning (PC) by exogenous hydrogen sulfide (H 2 S) in aged rat hearts. We observed that ischemia/reperfusion (I/R) inhibited phosphorylation extracellular signal‐regulated kinase 1/2 (ERK1/2) and promoted p38 MAPK c‐Jun N‐terminal (JNK) both young hearts PC up‐regulated ERK1/2 phosphorylations down‐regulated JNK phosphorylations. Exogenous H S further enhanced role In hearts,...
Placenta previa and accreta with prior cesarean section is an extremely serious condition that associated maternal morbidity mortality from obstetric hemorrhage. The aim of our study was to evaluate the efficacy advantages a novel surgical technique, parallel transverse uterine incisions (PTUI), during conservative delivery in patients placenta accreta.This retrospective cohort including 124 pregnant women, who had at least 1 were diagnosed anterior between January 2014 October 2017. Using...
Our previous study implied a correlation between inhibitors of differentiation‐1 (Id‐1) and cervical cancer development. However, how Id‐1 contributes to carcinogenesis is unknown. In the present study, we used an in vitro transformation model investigate role cells. Human papillomavirus (HPV)‐immortalized epithelial cells (H8) were successfully transformed by exposure carcinogen N‐nitrosopyrrolidine (NPYR). The expression both RNA protein was significantly increased H8 cells, suggesting...
This research investigates the interplay between Reactive Oxygen Species (ROS) and Apelin (APLN) in regulating autophagy, with implications for placental cell senescence apoptosis pre-eclampsia (PE). We manipulated APLN expression using sgRNA to study its effects on ROS levels subsequent cellular responses. Our findings reveal that overexpression elevates production, accelerating apoptosis. In contrast, silencing enhances thereby diminishing aging These outcomes were confirmed vitro vivo...