A5000282458- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Cell Function and Interaction
- Aquaculture disease management and microbiota
- Wound Healing and Treatments
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- Systemic Sclerosis and Related Diseases
- RNA Interference and Gene Delivery
- Oral Health Pathology and Treatment
- CAR-T cell therapy research
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- Inflammatory Biomarkers in Disease Prognosis
- Respiratory Support and Mechanisms
- IL-33, ST2, and ILC Pathways
- Invertebrate Immune Response Mechanisms
- Inflammation biomarkers and pathways
- Air Quality and Health Impacts
- Oral microbiology and periodontitis research
- Sepsis Diagnosis and Treatment
- FOXO transcription factor regulation
- Signaling Pathways in Disease
- Immune Response and Inflammation
- Extracellular vesicles in disease
Sichuan University
2021-2022
State Key Laboratory of Oral Diseases
2021-2022
China Medical University
2019-2021
City University of Hong Kong
2012
Sapporo Medical University
2012
Calcitonin gene-related peptide (CGRP) is an important neuropeptide expressed in the nerve fibers during bone repair. Here, we aimed to pinpoint role of CGRP osteogenic differentiation property human periodontal ligament stem cells (hPDLSCs) and resultant repair alveolar defect. The key factor related hPDLSCs was retrieved from GEO database. After extraction hADSCs (hADSC-EVs) identification, EVs were subjected coculture with hPDLSCs, which expression patterns marker proteins (ALP, RUNX2,...
Abstract Emphysematous smokers with normal spirometry form a considerable proportion of the clinical population. However, despite presenting respiratory symptoms and activity limitation, they cannot be diagnosed chronic obstructive lung disease (COPD) according to current criteria. Thus, we aimed determine whether emphysema in has different pathogenesis from that patients COPD. We compared 12 pairs tissue samples emphysematous COPD, determined degree using computed tomography. With focus on...
Abstract Aim In this study, we aimed to explore the effects of microRNA‐203 (miR‐203) on Porphyromonas gingivalis lipopolysaccharide ( P . g LPS)‐stimulated periodontal ligament cells (PDLCs) and identify potential molecular targets for periodontitis treatment. Methods Periodontal were stimulated by LPS, followed quantification miR‐203 AP ‐ 1 expression. Next, loss‐ gain‐of‐function experiments applied in LPS‐induced PDLCs. The proliferation, apoptosis, differentiation PDLCs determined,...
Background: The mechanisms underlying differences in the susceptibility to chronic obstructive pulmonary disease (COPD) exacerbations between patients are not well understood. Recent studies have shown that with frequent COPD is related specific protein expression lung tissue. Anterior gradient 3 (AGR3) expressed airway epithelial cells and proteomic analysis revealed its decreased exacerbations. Moreover, loss of integrity might facilitate trans-epithelial permeability pathogens such...
Abstract OSAS is attributable to periodic collapse of the upper airway due adenotonsillar hypertrophy, featuring prominent germinal centers and wide interfollicular zones. However, mechanism still unclear. Here we present possible involvement Tfh cells in pathogenesis as indicated by comprehensive analysis tonsillar lymphocytes patients. The results revealed that were plentiful compared recurrent tonsillitis (RT) without any discrepancy T-cell components between tonsils RT patients,...
Frequent exacerbator of chronic obstructive pulmonary disease (COPD) is a newly proposed independent phenotype, which characterized by poor quality life, increased mortality, decreased lung function and prognosis.In recent years, more studies on the pathogenesis this phenotype have been carried out, suggesting that it related to immune inflammation.Therefore, paper reviews role inflammation including innate immunity, cellular immunity humoral response in frequent COPD. Key words:...