A5031247370- FOXO transcription factor regulation
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Liver Diseases and Immunity
- Phagocytosis and Immune Regulation
- Hippo pathway signaling and YAP/TAZ
- Kruppel-like factors research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Digestive system and related health
- Cancer Immunotherapy and Biomarkers
- Fibroblast Growth Factor Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- Inflammatory Bowel Disease
- Cancer Research and Treatments
- Developmental Biology and Gene Regulation
- Colorectal Cancer Screening and Detection
- Cellular Mechanics and Interactions
- IL-33, ST2, and ILC Pathways
Huazhong University of Science and Technology
2018-2023
Tongji Hospital
2018-2023
Shangrao Normal University
2023
Forkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. family protein lays pivotal role in metabolism. ROS involved tumor progression associated with expression lots transcription factors. We next explored mechanism underlying FOXC1 modulating metabolism hemostasis HCC.We used amino acids arrays to verify which FOXC1-induced HCC. The kits were detect levels cells over-expression or down-expression FOXC1. After identified downstream...
Abstract Objectives Induction of deactivation and apoptosis hepatic stellate cells (HSCs) are principal therapeutic strategies for liver fibrosis. Krüppel‐like factor 14 (KLF14) regulates various biological processes, however, roles, mechanisms implications KLF14 in fibrosis unknown. Materials Methods expression was detected human, rat mouse fibrotic models, its effects on HSCs were assessed. Chromatin immunoprecipitation assays utilized to investigate the binding peroxisome...
Abstract Increasing evidence has revealed that cancer cells undergoing an intermediate state, partial epithelial mesenchymal transition (p‐EMT), tend to metastasize rather than complete EMT. We performed a comprehensive analysis of E‐cadherin and 25 p‐EMT‐related genes in HCC explore the roles regulatory mechanisms them HCC. analysed constructed mRNA‐miRNA‐lncRNA ceRNA subnetwork containing by bioinformatic approaches. IHC was used identify protein expression key genes, P4HA2, ITGA5, MMP9,...
// Yunwu Wang 1 , Yu Xu Wei Yan Ping Han Jingmei Liu Jin Gong Dongxiao Li Xiangming Ding Zhuoying Lin Dean Tian and Jiazhi Liao Department of Gastroenterology, Tongji Hospital Medical College, Huazhong University Science Technology, Wuhan, Hubei Province, China Correspondence to: Tian, email: datian@tjh.tjmu.edu.cn Liao, liaojiazhi@tjh.tjmu.edu.cn Keywords: hepatocellular carcinoma; CFIm25; alternative polyadenylation; EMT; metastasis Received: August 05, 2017 Accepted: December Published:...
Abstract Gene fusions caused by cytogenetic aberrations play important roles in the initiation and progression of cancers. The recurrent MTAP-ANRIL fusion gene was reported to have a frequency greater than 7% melanoma our previous study. However, its functions remain unclear. Truncated MTAP proteins resulting from point mutations last three exons can physically interact with wild-type protein, tumor suppressor several human Similarly, MTAP-ANRIL, which is translated into truncated would...
The incidence of autoimmune hepatitis (AIH) has increased significantly worldwide. present study aims to explore the protective effect L-lysine supplementation against AIH and investigate its potential underlying mechanisms. A chronic experimental mouse model was established by repeated tail vein injection human cytochrome P450 2D6 (CYP2D6) plasmid. Starting from day 14 modeling, mice in CYP2D6-AIH +L-lysine group were given 200 μl purified water containing 10 mg/kg gavage until day27, once...
Adequate bowel preparation is essential for colonoscopy, which important detecting colon polyps and preventing colorectal cancer. Linaclotide approved irritable syndrome with predominant constipation (IBS-C) symptoms. The main objective of this study was to explore the quality by low-volume compound polyethylene glycol (PEG) combined linaclotide.A total 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 2022 were randomized 1 3 split PEG regimens: 4LPEG,...
Abstract Background: Forkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. family protein lays pivotal role in metabolism. ROS involved tumor progression associated with expression lots transcription factors. We next explored mechanism underlying FOXC1 modulating metabolism hemostasis HCC. Methods: used amino acids arrays to verify which FOXC1-induced The kits were detect levels cells over-expression or down-expression FOXC1. After...
Abstract Systemic therapy has become the standard treatment for patients with advanced hepatocellular carcinoma (HCC) whose options are limited. However, long-term patient response to drugs and survival outcomes remain a concern. With increasing exploration of HCC microenvironment, particularly in terms T lymphocyte immunity, new era immunomolecular targeted therapy, based on molecular signaling, arrived HCC. In study immune tolerance intrinsic we found that multiple immunosuppressive...