A5101977937- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Analytical Chemistry and Sensors
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Microbial Metabolic Engineering and Bioproduction
- PI3K/AKT/mTOR signaling in cancer
- 2D Materials and Applications
- Carbon and Quantum Dots Applications
- Electrochemical sensors and biosensors
- Epigenetics and DNA Methylation
- Electronic Packaging and Soldering Technologies
- Prion Diseases and Protein Misfolding
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Histone Deacetylase Inhibitors Research
- Natural Fiber Reinforced Composites
- bioluminescence and chemiluminescence research
- Polymer crystallization and properties
- Protein Kinase Regulation and GTPase Signaling
- Antimicrobial agents and applications
- Pharmacological Receptor Mechanisms and Effects
- CRISPR and Genetic Engineering
- Anodic Oxide Films and Nanostructures
- Biochemical and biochemical processes
Shenzhen Technology University
2024-2025
Shenzhen University
2024-2025
Wuhan Textile University
2024
Chinese Academy of Sciences
2017-2024
Shenzhen Institutes of Advanced Technology
2023-2024
Shenzhen Second People's Hospital
2023-2024
Changchun University of Technology
2024
Guangzhou Medical University
2023
Institute of Biophysics
2021-2022
Tianjin Institute of Industrial Biotechnology
2017-2018
The Hippo signaling pathway plays a crucial role in tissue growth and tumorigenesis. Core components of the include MST1/2 Lats1/2 kinases. Acting downstream from are YAP/TAZ transcription coactivators, which inhibited through phosphorylation by Lats. However, upstream signals that regulate have not been well delineated. Here we report stimulation protease-activated receptors (PARs) activates decreasing increasing nuclear localization. PAR1 acts G 12/13 Rho GTPase to inhibit kinase. Our...
Abstract DNMT1 is an important epigenetic regulator that plays a key role in the maintenance of DNA methylation. Here we determined crystal structure complex with USP7 at 2.9 Å resolution. The interaction between two proteins primarily mediated by acidic pocket and Lysine residues within DNMT1’s KG linker. This intermolecular required for USP7-mediated stabilization DNMT1. Acetylation linker impair DNMT1–USP7 promote degradation Treatment HDAC inhibitors results increase acetylated decreased...
Abstract UHRF1 is an important epigenetic regulator for maintenance DNA methylation. recognizes hemi-methylated (hm-DNA) and trimethylation of histone H3K9 (H3K9me3), but the regulatory mechanism remains unknown. Here we show that adopts a closed conformation, in which C-terminal region (Spacer) binds to tandem Tudor domain (TTD) inhibits H3K9me3 recognition, whereas SET-and-RING-associated (SRA) plant homeodomain (PHD) H3R2 recognition. Hm-DNA impairs intramolecular interactions promotes...
A new directed evolution approach is presented to enhance the activity of an enzyme and manipulate stereoselectivity by focusing iterative saturation mutagenesis (ISM) simultaneously on residues lining entrance tunnel binding pocket. This combined strategy was applied successfully monoamine oxidase from Aspergillus niger (MAO-N) in reaction sterically demanding substrates which are interest synthesis chiral pharmaceuticals based benzo-piperidine scaffold. Reversal enantioselectivity...
Abstract One of the long‐sought‐after goals in responsive material development is to generate and tune colors for advanced emerging applications such as dynamic displays, light‐emitting diodes, lasers, smart windows, chromic fabrics, high‐security encryption, visual sensors. Benefiting from atomically thin nature well strong optical interaction, two‐dimensional (2D) materials can serve color‐generating centers both chemical pigment physical interference solution, gels, films, matrix...
A fluorescent chemodosimeter containing a guanidiniocarbonylpyrrole and 9-(aminomethyl)anthracene moiety has been synthesized. The sensor exhibits ratiometric fluorescence changes for SO(3)(2-) over other anions in 90% water/DMSO. interesting are attributed to the resonance energy transfer (FRET) complex induced photochemical reaction.
The target of rapamycin (TOR) complex 1 (TORC1) is a central cell growth regulator in response to wide array signals. Rag GTPases play an essential role relaying amino acid signals TORC1 activation through direct interaction with raptor and recruitment the lysosomes. Here we present crystal structure Gtr1p-Gtr2p complex, homologs from Saccharomyces cerevisiae, at 2.8 Å resolution. heterodimeric reveal pseudo-twofold symmetric organization. Structure-guided functional analyses RagA-RagC,...
Abstract Low-dimensional materials exhibit unique quantum confinement effects and morphologies as a result of their nanoscale size in one or more dimensions, making them distinctive physical properties compared to bulk counterparts. Among all low-dimensional materials, due atomic level thickness, two-dimensional possess extremely large shape anisotropy consequently are speculated have optically anisotropic absorption. In this work, we demonstrate an optoelectronic device based on the...
By utilizing a displacement method, macrocyclic compound 1, could report the presence of sulfide anion, with detection limit 7.0 × 10−7 mol/L; moreover, no interference was observed from other anions, including SO32−, HSO3−, SO42−, ClO4−, I−, Br−, Cl−, F−, IO3−, HPO42−, PO43−, C2O42−, S2O32−, CO32−, AcO−, CN− and P2O74−, making 1 new, highly sensitive selective anion chemosensor.
ABSTRACT To construct a universal vaccine against mastitis induced by either Streptococcus agalactiae or Staphylococcus aureus , the B cell epitopes of surface immunogenic protein (Sip) from S. and clumping factor A (ClfA) were analyzed predicted. sip - clfA novel chimeric epitope-based gene, was obtained overlap PCR, then recombinant Sip-ClfA (rSip-ClfA) expressed purified. rSip-ClfA inactivated formulated into different vaccines with mineral oil as adjuvant evaluated in mouse models. The...
A new 4-amino-1,8-naphthalimide-based fluorescent chemosensor bearing a guanidiniocarbonyl pyrrole moiety has been synthesized. The sensor displays selective enhancement with pyrophosphate over ATP, ADP, AMP and other inorganic anions in aqueous solution.