A5101741220- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Xenotransplantation and immune response
- COVID-19 Clinical Research Studies
- Organ Donation and Transplantation
- Organ and Tissue Transplantation Research
- Animal Genetics and Reproduction
- COVID-19 Impact on Reproduction
- Transplantation: Methods and Outcomes
- Antibiotic Resistance in Bacteria
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Neurological Complications and Syndromes
- Pharmacological Effects and Toxicity Studies
- Virus-based gene therapy research
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Infectious Encephalopathies and Encephalitis
- T-cell and B-cell Immunology
- Pregnancy and Medication Impact
- Complement system in diseases
- Blood groups and transfusion
- Pneumocystis jirovecii pneumonia detection and treatment
- Cell Adhesion Molecules Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Ministry of Education of the People's Republic of China
2016-2025
Southern University of Science and Technology
2025
Saudi Center for Organ Transplantation
2024
National Health and Family Planning Commission
2020-2023
Union Hospital
2014
Terasaki Foundation
2008-2009
The current outbreak of Coronavirus Disease 2019 (COVID-19) has raised great concern worldwide, but its impact on transplant recipients is unknown. We report here the clinical features and therapeutic course first reported renal recipient with confirmed COVID-19 pneumonia. This a 52-year-old man who received kidney transplantation 12 years ago. His overall characteristics (symptoms, laboratory examinations, chest CT) were similar to those non-transplanted patients. Following treatment...
Evidence shows posttransplant antibodies lead to renal allograft failure, but does the time elapsed between transplantation and antibody development impact survival? This is first study showing importance of when appear.Serial sera were collected during 17 years (1991-2008) from two groups patients, one whose failed due chronic rejection containing 25 patients (230 sera) a control group consisting graft functioning (305 who matched by transplant date patient failed.The median follow-up for...
Effective treatment of late antibody-mediated rejection (late AMR) is still an unmet medical need. Clearing donor-specific antibody (DSA) and preventing its rebound the ideal goal treatment. We have summarized clinical data from seven patients with or chronic active AMR after renal transplantation who received daratumumab (Dara)-based first (Phase 1) then tocilizumab (TCZ) therapy 2). Phase 1 consisted intensive period (Dara plus PP/IVIG) a maintenance alone). The main indicators were DSA,...
Background Late or chronic active antibody-mediated rejection (AMR) associated with de novo donor-specific antibodies (dnDSA) after renal transplantation is a great clinical challenge because it often resistant to conventional therapies. Daratumumab, an anti-CD38 monoclonal antibody that can deplete plasma cells, may be effective for the treatment of late AMR. Methods We designed novel regimen included early intensive therapy daratumumab plus plasmapheresis (PP)/intravenous immunoglobulins...
Gene-edited pigs for xenotransplantation usually contain one or more transgenes encoding human complement regulatory proteins (CRPs). Because of species differences, CRP(s) expressed in gene-edited may have difficulty inhibiting the activation exogenous rabbit added to a complement-dependent cytotoxicity (CDC) assay. The use instead CDC experiments accurately reflect actual activity CRP(s). Peripheral blood mononuclear cells (PBMCs) were obtained from GTKO pig and two GTKO/hCD55 with high...
Objective: To investigate the efficacy of dual kidney transplantation (DKT) from adult donors. Methods: Clinical data DKT donors and recipients in Institute Organ Transplantation, Tongji Hospital, Medical College, Huazhong University Science Technology March 2015 to June 2024 were retrospectively analyzed. The patients followed up until September 2024. clinical donor recipient, kidney, surgical techniques, complications, follow-up collected. Transplant renal function recipient/graft survival...
ABSTRACT Background Gene‐edited pigs for xenotransplantation usually contain one or more transgenes encoding human complement regulatory proteins (CRPs). Because of species differences, CRP(s) expressed in gene‐edited may have difficulty inhibiting the activation exogenous rabbit added to a complement‐dependent cytotoxicity (CDC) assay. The use instead CDC experiments accurately reflect actual activity CRP(s). Methods Peripheral blood mononuclear cells (PBMCs) were obtained from GTKO pig and...
Abstract Pediatric donor kidneys show rapid compensatory development in morphology and function after being transplanted into adult recipients. Establishing an animal model that can simulate clinical pediatric‐to‐adult (P→A) kidney transplantation is important for studying the characteristics potential mechanisms related to this graft growth. In P→A group, harvested from 3‐ 4‐week‐old Sprague–Dawley (SD) rats weighing <50 g were SD (300‐400 g). Novel techniques employed using recipient...
LETTER TO THE EDITOR Transpl Int, 22 August 2023 https://doi.org/10.3389/ti.2023.11771
Abstract Background In recent years, the implementation of first case pig‐to‐human heart xenotransplantation and report three cases pig‐to‐brain‐dead human recipient kidney transplantation indicate that is getting closer to clinical application. near future, China may also launch trials xenotransplantation. Therefore, it necessary investigate level knowledge acceptance among transplant recipients candidates in China. This study aims comprehension explore related factors, providing a...
ABSTRACT Background Long‐term immunosuppressive maintenance therapy is necessary to prevent the rejection of xenografts. However, it still unclear which oral immunosuppressant most suitable for pig‐to‐human xenotransplantation . Methods A xenogeneic mixed lymphocyte reaction (MLR) system was established using peripheral blood mononuclear cells (PBMCs) isolated from wildtype (WT) or GTKO/CMAHKO/β4GalNT2KO (TKO) pigs as stimulator and human PBMCs responder cells. Various concentrations...
It has been reported that kidney retransplant patients had high rates of early acute rejection due to previous sensitization. In addition the antibody-mediated (ABMR) received widespread attention, T-cell-mediated (TCMR) may be another important issue in renal retransplantation. current single-center retrospective study, we included 33 and 90 first transplant with similar protocols induction maintenance therapy. Analysis focused particularly on incidence patterns episodes, as well one-year...
Using pediatric donors for single-kidney transplantation (SKT) can increase the number of possible recipients. However, it is unclear when SKT involving small and adult recipients safely be performed without compromising graft outcome.From 2013 to 2017, a total 102 SKTs in were our center using aged <12 years. We compared outcomes from 8 36 months (the small-kidney group [SKG], n = 46) 3 12 years big-kidney [BKG], 56). The median follow-up time was 30 SKG 28 BKG.All patients achieved...
The causative virus of coronavirus disease 2019 (COVID-19) may cause severe fatal pneumonia. clinical presentation includes asymptomatic infection, pneumonia, and acute respiratory failure. Data pertaining to renal injury due COVID-19 in patients who have undergone transplantation are scarce. We herein report two cases along with kidney following transplantation.Case presentation: Two underwent were subsequently diagnosed injury. first patient presented progressive symptoms He was treated...
Chronic active antibody-mediated rejection (AMR) in renal transplantation is usually refractory to current conventional treatment with rituximab, plasmapheresis (PP), and intravenous immunoglobulins (IVIG). Splenic irradiation has been reported be effective the rescue of early severe acute AMR after kidney transplantation; however, its effect chronic not date. In order reduce donor-specific antibody (DSA) prevent progression AMR, we used repetitive low-dose splenic irradiation, together...
Abstract Background Both the complement and coagulation systems play important roles in development of hyperacute or acute antibody‐mediated xenograft rejection. Atrase B is a novel metalloproteinase isolated from venom Naja atra . In this study, we investigated inhibitory effects atrase on activation coagulation, as well effect survival discordant xenotransplantation model. Methods The vitro anti‐complement activity was evaluated using normal human serum (NHS)‐mediated complement‐dependent...