A5050759194- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Bone health and treatments
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
- Sex work and related issues
- Virus-based gene therapy research
- Inflammatory mediators and NSAID effects
- Sports injuries and prevention
- Viral Infections and Immunology Research
- Chemokine receptors and signaling
- Musculoskeletal synovial abnormalities and treatments
- Animal Virus Infections Studies
- RNA Research and Splicing
- LGBTQ Health, Identity, and Policy
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
Children's Hospital of Philadelphia
2020-2023
Chongqing Medical University
2022
Osteoarthritis (OA) is the leading joint disease characterized by cartilage destruction and loss of mobility. Accumulating evidence indicates that incidence severity OA increases with diabetes, implicating systemic glucose metabolism in health. However, a definitive link between cellular articular pathogenesis not yet established. Here, we report mice surgically induced to develop knee through destabilization medial meniscus (DMM), expression main transporter Glut1 notably reduced cartilage....
Skeletal fragility is associated with type 2 diabetes mellitus (T2D), but the underlying mechanism not well understood. Here, in a mouse model for youth-onset T2D, we show that both trabecular and cortical bone mass reduced due to diminished osteoblast activity. Stable isotope tracing vivo 13 C-glucose demonstrates glycolysis glucose fueling of TCA cycle are impaired diabetic bones. Similarly, Seahorse assays suppression oxidative phosphorylation by marrow mesenchymal cells as whole, whereas...
Osteoclasts specialize in bone resorption and are critical for remodeling. Previous studies have shown that osteoclasts possess abundant mitochondria derive most energy through oxidative phosphorylation (OXPHOS). However, the substrates fueling OXPHOS remain to be fully defined. Here, we showed osteoclast differentiation was coupled with increased oxidation of glucose, glutamine, oleate. Transcriptomic analyses RNA sequencing revealed marked upregulation genes participating mitochondrial...
Osteoarthritis (OA) is the most common arthropathy, characterized by progressive degeneration of articular cartilage. Currently, there are no disease-modifying approaches for OA treatment. Adeno-associated virus (AAV)-mediated gene therapy has recently become a potential treatment due to its exceptional characteristics; however, tropism and transduction efficiency different AAV serotypes joints safety profile applications still unknown. The present study aims screen an ideal serotype...
Abstract Background The Anterior cruciate ligament (ACL) is one of the most easily injured ligaments in knee. Abnormal femur and knee rotation may lead to ACL injury, while an increased proportion lateral femoral condyle also a potential factor injury. Therefore, distal torsion (DFT) be closely related Thus, this study aims investigate associations DFT with risk injury severity Methods 582 patients who received reconstruction surgery between 2014 2019 were examined retrospectively, 114...