Rachel Gregor
A5028203074- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Bacterial biofilms and quorum sensing
- Microbial Community Ecology and Physiology
- Inorganic and Organometallic Chemistry
- Analytical Chemistry and Chromatography
- Scientific Computing and Data Management
- Sex and Gender in Healthcare
- Social Media in Health Education
- Antimicrobial Peptides and Activities
- Advanced Chemical Sensor Technologies
- Ethics in Clinical Research
- Biochemical and Structural Characterization
- Mass Spectrometry Techniques and Applications
- Research Data Management Practices
- Bacterial Genetics and Biotechnology
- Microbial Natural Products and Biosynthesis
- Molecular Sensors and Ion Detection
- Marine and coastal ecosystems
- Chemical Reaction Mechanisms
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Immune Response and Inflammation
- Medicine and Dermatology Studies History
Massachusetts Institute of Technology
2021-2024
Ben-Gurion University of the Negev
2016-2021
UNSW Sydney
1992-1995
Abstract microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbe-derived metabolites relative without priori knowledge will vastly enhance the understanding microorganisms’ role ecology human health.
Emerging antibiotic resistance among human pathogens has galvanized efforts to find alternative routes combat bacterial virulence. One new approach entails interfering with the ability of bacteria coordinate population-wide gene expression, or quorum sensing (QS), thus inhibiting production virulence factors and biofilm formation. We have recently developed such a strategy by targeting LasR, master regulator QS in opportunistic pathogen Pseudomonas aeruginosa, through rational design...
Abstract In the past decade, studies on mammalian gut microbiome have revealed that different animal species distinct microbial compositions. The functional ramifications of this variation in composition remain unclear: do these taxonomic differences indicate adaptations to host-specific functionality, or are diverse communities essentially functionally redundant, as has been indicated by previous metagenomics studies? Here, we examine metabolic content microbiomes a direct window into...
Microbiology conferences can be powerful places to build collaborations and exchange ideas, but for queer transgender (trans) scientists, they also become sources of alienation isolation. Many conference organizers would like create welcoming inclusive events feel ill-equipped make this vision a reality, historical lack representation trans folks in microbiology means we rarely occupy these key leadership roles ourselves. Looking more broadly, scientists are systematically marginalized...
The major vault protein (MVP) mediates diverse cellular responses, including cancer cell resistance to chemotherapy and protection against inflammatory responses Pseudomonas aeruginosa Here, we report the use of photoactive probes identify MVP as a target N-(3-oxo-dodecanoyl) homoserine lactone (C12), quorum sensing signal certain proteobacteria P. aeruginosa. A treatment normal cells with C12 or other N-acyl lactones (AHLs) results in rapid translocation into lipid raft (LR) membrane...
As queer and trans scientists, we face varied systemic barriers to our professional success, resulting in relative absence from faculty ranks at many institutions. In this Perspective, call for a change hiring practices present concrete guidance make it more inclusive process.
Abstract Access to web-based platforms has enabled scientists perform research remotely. A critical aspect of mass spectrometry data analysis is the inspection, analysis, and visualization raw validate quality confirm statistical observations. We developed GNPS Dashboard, a tool, facilitate synchronous collaborative visualization, private public
Abstract MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbial-derived metabolites relative producers, without priori knowledge, will vastly enhance the understanding microorganisms’ role ecology...
Abstract MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbial-derived metabolites relative producers, without priori knowledge, will vastly enhance the understanding microorganisms' role ecology...
Queer and transgender scientists face documented systemic challenges across the sciences, as a result have higher attrition rate than their peers. Recent calls for change within microbiology emphasized importance of addressing barriers to success retention queer trans microbiologists create more inclusive, equitable, just scientific establishment. Crucially, we note these come primarily from early career researchers; relatively few us passed through gauntlet faculty job search, this is key...
Abstract Microbial community assembly is governed by trophic interactions that mediate the transfer of carbon sources and biomass building blocks between species. However, central metabolism corresponds to only a small fraction biosynthetic potential microbes: metabolites such as antimicrobial compounds, signaling molecules, co-factors are underexplored forces shaping microbial communities. Here, we focus on B vitamin exchange in coastal marine bacterial communities degrade particulate...
Abstract Gas chromatography-mass spectrometry (GC-MS) represents an analytical technique with significant practical societal impact. Spectral deconvolution is essential step for interpreting GC-MS data. No public repositories that also enable repository-scale analysis exist, in part because requires user input. We therefore engineered a scalable machine learning workflow the Global Natural Product Social Molecular Networking (GNPS) platform to mass community store, process, share, annotate,...
Bacteria assess their population density through a chemical communication mechanism termed quorum sensing, in order to coordinate group behavior. Most research on sensing has focused primarily its role as an intraspecies signaling that enables the regulation of certain phenotypes targeted gene expression. However, recent years several seminal studies have revealed important phenomena which molecules appear serve additional roles interspecies signals may regulate microbial ecology. In this...
Microbiology conferences can be powerful places to build collaborations and exchange scientific thought, but for queer transgender (trans) scientists they also become sources of alienation isolation. Many conference organizers would like create welcoming inclusive events feel ill-equipped make this vision a reality, historical lack representation trans folks in microbiology means we rarely occupy these key leadership roles ourselves. Looking more broadly, are systematically marginalized...
Abstract Gas‐phase reactions between 13 CO 2 and C 18 O a series of carbonyl metallate ions [Metal(CO) x ] − with x=3, 4 for the metals chromium, manganese, iron also x=2 iron, have ben examined at low pressures by Fourier‐transform ion cyclotron resonance mass spectrometry. while 16‐and 17‐electron [Mn(CO) [Fe(CO) were unreactive, both ligand displacement oxidative been identified other 13‐, 14‐ 15‐electron metal‐ion systems as consequences Metal‐C, O OC cleavages in [(CO) . Metal. η...
Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as potent modulator macrophage activity and inflammation.
Abstract Recent studies have shown that microbial communities are composed of groups functionally cohesive taxa, whose abundance is more stable and better associated with metabolic fluxes than any individual taxon. However, identifying these functional in a manner independent from error-prone gene annotations remains major open problem. Here, we develop novel approach identifies taxa an unsupervised manner, solely based on the patterns statistical variation species environmental parameters....