Adriana Vasquez Ayala
A5092516382- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- Immune Response and Inflammation
- Infant Nutrition and Health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Bacterial Identification and Susceptibility Testing
- Escherichia coli research studies
- Immune Cell Function and Interaction
University of California, San Diego
2021-2024
Abstract microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbe-derived metabolites relative without priori knowledge will vastly enhance the understanding microorganisms’ role ecology human health.
Type I interferons (IFNs) exert a broad range of biological effects important in coordinating immune responses, which have classically been studied the context pathogen clearance. Yet, whether immunomodulatory bacteria operate through IFN pathways to support intestinal tolerance remains elusive. Here, we reveal that commensal bacterium, Bacteroides fragilis, utilizes canonical antiviral modulate dendritic cells (DCs) and regulatory T cell (Treg) responses. Specifically, signaling is required...
SUMMARY Bacteroides fragilis is a prominent member of the human gut microbiota, playing crucial roles in maintaining homeostasis and host health. Although it primarily functions as beneficial commensal, B. can become pathogenic. To determine genetic basis its duality, we conducted comparative genomic analysis 813 strains, representing both commensal pathogenic origins. Our findings reveal that strains emerge across diverse phylogenetic lineages, due part to rapid gene exchange adaptability...
Abstract MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbial-derived metabolites relative producers, without priori knowledge, will vastly enhance the understanding microorganisms’ role ecology...
Abstract MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbial-derived metabolites relative producers, without priori knowledge, will vastly enhance the understanding microorganisms' role ecology...
ABSTRACT The early microbial colonization of the gastrointestinal tract can lead to long-term impacts in development and overall human health. Keystone species, including Bacteroides spp ., play a crucial role maintaining structure, diversity, function intestinal ecosystem. However, process by which defined resilient community is curated maintained during life remains inadequately understood. Here, we show that single sialidase, NanH, fragilis mediates stable occupancy mucosa regulates...
ABSTRACT Type I interferons (IFN) exert a broad range of biological effects important in coordinating immune responses. Host and microbial factors regulate IFN production, triggering signaling cascade that has classically been studied the context pathogen clearance. In particular, commensal bacteria have shown to induce protect against viral infections. Yet, whether immunomodulatory operate through pathways support tolerance remains elusive. Here, we demonstrate microbiota-dependent is...