Carlismari O. Grundmann
A5066858147- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Advanced Chemical Sensor Technologies
- Essential Oils and Antimicrobial Activity
- Analytical Chemistry and Chromatography
- Sesquiterpenes and Asteraceae Studies
- Mass Spectrometry Techniques and Applications
- Insect Utilization and Effects
- Insect Pest Control Strategies
- Insect symbiosis and bacterial influences
- Natural product bioactivities and synthesis
Universidade de São Paulo
2017-2024
University of Montana
2020-2021
University of California, San Diego
2020-2021
Universidade de Ribeirão Preto
2017
Abstract Molecular networking connects mass spectra of molecules based on the similarity their fragmentation patterns. However, during ionization, commonly form multiple ion species with different behavior. As a result, these often remain unconnected in tandem spectrometry-based molecular networks, leading to redundant and disconnected sub-networks same compound classes. To overcome this bottleneck, we develop Ion Identity Networking (IIMN) that integrates chromatographic peak shape...
Abstract microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbe-derived metabolites relative without priori knowledge will vastly enhance the understanding microorganisms’ role ecology human health.
Covering: September 1964 to June 2023Bacteria and fungi living in symbiosis with insects have been studied over the last sixty years found be important sources of bioactive natural products. Not only classic producers secondary metabolites such as
This study reports on the chemical composition and antimicrobial activity of essential oil from Artemisia absinthium L. leaves AA EO collected in Brazil against a representative panel cariogenic bacteria. The minimum inhibitory concentrations MICs were determined by broth dilution method 96-well microplates. was inactive most investigated oral pathogens, but it displayed moderate Streptococcus mutans MIC = 250 μg/mL very promising mitis 62.5 μg/mL. Gas chromatography GC FID gas mass...
Abstract Molecular networking connects tandem mass spectra of molecules based on the similarity their fragmentation patterns. However, during ionization, commonly form multiple ion species with different behavior. To connect same molecule, we developed Ion Identity Networking. These new relationships improve network connectivity, are shown to reveal novel ion-ligand complexes, enhance annotation within molecular networks, and facilitate expansion spectral libraries.
Abstract MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbial-derived metabolites relative producers, without priori knowledge, will vastly enhance the understanding microorganisms’ role ecology...
Abstract MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbial-derived metabolites relative producers, without priori knowledge, will vastly enhance the understanding microorganisms' role ecology...