Alexandre Bory
A5038848100- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Mycobacterium research and diagnosis
- Plant biochemistry and biosynthesis
- Photosynthetic Processes and Mechanisms
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Venomous Animal Envenomation and Studies
- Antioxidant Activity and Oxidative Stress
- Fungal Biology and Applications
- Marine Sponges and Natural Products
University of Geneva
2022-2025
HES-SO University of Applied Sciences and Arts Western Switzerland
2025
University of South Florida
2020
University of Fribourg
2017
Abstract microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbe-derived metabolites relative without priori knowledge will vastly enhance the understanding microorganisms’ role ecology human health.
Antibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies restore antibiotic efficacy include targeting multidrug efflux pumps by competitive pump inhibitors. These could be derived from natural substrates of these systems. In this work, we aimed elucidate the clinically relevant Mex Pseudomonas aeruginosa untargeted metabolomic approach. We constructed a PA14 mutant, genetically deleted in major MexAB-OprM, MexCD-OprJ, MexXY-OprM, and MexEF-OprN...
Photosynthetic organisms such as plants, algae and some cyanobacteria synthesize tocochromanols, a group of compounds that encompasses tocopherols tocotrienols exhibits vitamin E activity in animals. While most biosynthetic genes have been identified plant genomes, regulatory controlling tocopherol accumulation are currently unknown. We isolated by forward genetics Arabidopsis enhanced (eve) mutants overaccumulate the classic plastochromanol-8, tocochromanol unknown this species. mapped eve1...
The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted the generation a small chemical library containing diterpenoid secondary metabolites bioactivity an infectious disease screening campaign focused on Leishmania donovani, Plasmodium falciparum, and methicillin-resistant Staphylococcus aureus (MRSA) biofilm. In total, eleven natural products were isolated, including three new compounds...
Abstract MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbial-derived metabolites relative producers, without priori knowledge, will vastly enhance the understanding microorganisms’ role ecology...
Abstract MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbial-derived metabolites relative producers, without priori knowledge, will vastly enhance the understanding microorganisms' role ecology...
This project aims at the development of a screening platform for efficient antimicrobial hits prioritization originating from fungal strains. Given size collection (> 2500) and resulting number extracts, miniaturized approach was developed ([Fig. 1]).