A5068820590- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Advanced Proteomics Techniques and Applications
- Carcinogens and Genotoxicity Assessment
- Meat and Animal Product Quality
- Protein Hydrolysis and Bioactive Peptides
- Mass Spectrometry Techniques and Applications
- Gut microbiota and health
- Nanoparticle-Based Drug Delivery
- Analytical chemistry methods development
- Advanced biosensing and bioanalysis techniques
- Synthesis and Biological Evaluation
- Identification and Quantification in Food
- Nutritional Studies and Diet
- Characterization and Applications of Magnetic Nanoparticles
- Genomics and Phylogenetic Studies
- Phytochemicals and Antioxidant Activities
- Advanced Chemical Sensor Technologies
- Pharmaceutical and Antibiotic Environmental Impacts
- Diet and metabolism studies
- Selenium in Biological Systems
- Protein Interaction Studies and Fluorescence Analysis
- Biochemical Analysis and Sensing Techniques
- Nanopore and Nanochannel Transport Studies
- Algal biology and biofuel production
University of Copenhagen
2019-2024
Sapienza University of Rome
2014-2019
Institut Químic de Sarrià
1999
Universitat Ramon Llull
1999
Abstract microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging curated database of >60,000 monocultures, users can known and unknown MS/MS spectra link them to their respective producers via fragmentation patterns. Identification microbe-derived metabolites relative without priori knowledge will vastly enhance the understanding microorganisms’ role ecology human health.
When injected in a biological milieu, nanomaterial rapidly adsorbs biomolecules forming biomolecular corona. The corona changes the interfacial composition of giving it identity that determines physiological response. Characterization structure and has received increasing attention mostly due to its detrimental impact on nanomaterial's metabolism vivo. It is generally accepted an opsonin-enriched promotes immune system recognition rapid clearance from circulation. Here we applied dynamic...
As soon as nanomaterials, such nanoparticles (NPs), are injected into a physiological environment rich coating of biomolecules known the "protein corona" rapidly covers them. This protein dress is main factor, which affects interaction NPs with living systems. While relationship between NP features and biomolecule corona has been extensively investigated, whether how changes in affect NP–protein remains under-investigated. one most important steps translating results animal models to clinic....
Short peptide sequences represent emerging analytes in a variety of fields, including biomarker discovery, but also well-known analytical challenge complex matrices, due to the low abundance, extensive suppression during MS analysis, and lack workflows, as they cannot be identified by ordinary peptidomics strategies coverage is extremely limited metabolomics well. In this context, work, solid phase extraction method was developed for cleanup enrichment dipeptides, tripeptides, tetrapeptides...
The human gut microbiome is highly personal. However, the contribution of physiology and environment to variations in remains understudied. Here we performed an observational trial using multi-omics profile composition metabolism 61 healthy adults for 9 consecutive days. We assessed day-to-day changes environmental factors measured whole-gut segmental intestinal transit time pH a wireless motility capsule subset 50 individuals. observed substantial daily fluctuations, with intra-individual...
The exposure of human DNA to genotoxic compounds induces the formation covalent adducts, which may contribute initiation carcinogenesis. Liquid chromatography (LC) coupled with high-resolution mass spectrometry (HRMS) is a powerful tool for adductomics, new research field aiming at screening known and unknown adducts in biological samples. lack databases bioinformatics this limits applicability adductomics. Establishing comprehensive database will make identification process faster more...
Abstract The human gut microbiome is highly personal. However, the contribution of environment to variations in remains elusive. Here, we profiled composition and metabolism over 9 consecutive days 61 healthy adults assessed environmental factors including segmental transit time pH using a wireless motility capsule. Day-to-day fluctuations as well varied substantially between individuals. explained more urine metabolome than dietary macronutrients or personal characteristics. Finally,...