Caitlin Tribelhorn
A5021868586- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Metabolomics and Mass Spectrometry Studies
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 detection and testing
- Genomics and Phylogenetic Studies
- SARS-CoV-2 and COVID-19 Research
- Gene expression and cancer classification
- Plant Ecology and Taxonomy Studies
- COVID-19 diagnosis using AI
- Computational Drug Discovery Methods
- Nutritional Studies and Diet
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Biosensors and Analytical Detection
University of California, San Diego
2021-2024
Abstract As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing infeasible at scale, especially in areas with limited resources, participation, or and/or sequencing capacity, which can also introduce biases 1–3 . RNA concentration wastewater successfully tracks regional infection dynamics provides less biased abundance estimates than 4,5 Tracking virus genomic sequences...
As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing infeasible at scale, especially in areas with limited resources, participation, or testing/sequencing capacity, which can also introduce biases. RNA concentration wastewater successfully tracks regional infection dynamics provides less biased abundance estimates than testing. Tracking virus genomic sequences would...
ABSTRACT Next-generation sequencing technologies have enabled many advances across diverse areas of biology, with benefiting from increased sample size. Although the cost running next-generation instruments has dropped substantially over time, preparation methods lagged behind. To counter this, researchers adapted library miniaturization protocols and large pools to maximize number samples that can be prepared by a certain amount reagents sequenced in single run. However, due high...
SUMMARY Bacteroides fragilis is a prominent member of the human gut microbiota, playing crucial roles in maintaining homeostasis and host health. Although it primarily functions as beneficial commensal, B. can become pathogenic. To determine genetic basis its duality, we conducted comparative genomic analysis 813 strains, representing both commensal pathogenic origins. Our findings reveal that strains emerge across diverse phylogenetic lineages, due part to rapid gene exchange adaptability...
ABSTRACT Bacteroides fragilis is a Gram-negative commensal bacterium commonly found in the human colon, which differentiates into two genomospecies termed divisions I and II. Through comprehensive collection of 694 B. whole genome sequences, we identify novel features distinguishing these divisions. Our study reveals distinct geographic distribution with division strains predominantly North America II Asia. Additionally, are more frequently associated bloodstream infections, suggesting...
Despite extensive efforts, extracting information on medication exposure from clinical records remains challenging. To complement this approach, we developed the tandem mass spectrometry (MS/MS) based GNPS Drug Library. This resource integrates MS/MS data for drugs and their metabolites/analogs with controlled vocabularies sources, pharmacologic classes, therapeutic indications, mechanisms of action. It enables direct analysis drug metabolism untargeted metabolomics independent records. Our...
Emerging research suggests that diet plays a vital role in shaping the composition and function of gut microbiota. While significant efforts have been made to identify general patterns linking microbiome, much this lacks representation from low- middle-income countries such as Mexico. Additionally, both microbiome highly complex individualized configurations, there is growing evidence tailoring diets individual microbiota profiles may optimize path toward improving or maintaining health...
is a Gram-negative commensal bacterium commonly found in the human colon that differentiates into two genomospecies termed division I and II. We leverage comprehensive collection of 694