A5026431784- Bacillus and Francisella bacterial research
- Bone health and treatments
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Disaster Response and Management
- Bone Metabolism and Diseases
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Cell Adhesion Molecules Research
- COVID-19 epidemiological studies
- Hepatitis Viruses Studies and Epidemiology
- Travel-related health issues
- Viral gastroenteritis research and epidemiology
- Adolescent and Pediatric Healthcare
- SARS-CoV-2 detection and testing
- Poxvirus research and outbreaks
- Zoonotic diseases and public health
- Vitamin D Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Mosquito-borne diseases and control
- Bone and Dental Protein Studies
- Geriatric Care and Nursing Homes
- Digital Mental Health Interventions
- Mental Health and Patient Involvement
- Malaria Research and Control
Health and Human Services Agency
2020-2023
Uniformed Services University of the Health Sciences
2005-2020
Atrium Health Wake Forest Baptist
2020
Jackson Foundation
2019
Henry M. Jackson Foundation
2019
Georgia Department of Public Health
2017
Saint Francis Memorial Hospital
2016
Landcare Australia
2004-2012
MemorialCare Health System
2012
Pacific Northwest National Laboratory
2007-2009
Abstract As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing infeasible at scale, especially in areas with limited resources, participation, or and/or sequencing capacity, which can also introduce biases 1–3 . RNA concentration wastewater successfully tracks regional infection dynamics provides less biased abundance estimates than 4,5 Tracking virus genomic sequences...
The osteoclast, the multinucleated giant cell of bone, is derived from circulating blood cells, most likely monocytes. Evidence has accrued that consistent with hypothesis recruitment monocytes for osteoclast development occurs by chemotaxis. In present study, we have examined chemotactic response human peripheral and related polymorphonuclear leucocytes to three constituents bone matrix: peptides Type I collagen, alpha 2-HS glycoprotein, osteocalcin (bone gla protein). latter two substances...
To describe rapid implementation of telehealth during the COVID-19 pandemic and assess for disparities in video visit Appalachian region United States.A retrospective cohort consecutive patients seen first 4 weeks was identified from Neurology Ambulatory Practice at a large academic medical center. Telehealth visits defaulted to video, when unable, phone-only were scheduled. Patients divided into 2 groups based on type: or phone only. Clinical variables collected electronic record including...
To test the hypothesis that mononuclear cells are stimulated to release interleukin 1 (IL-1) by bone fragments released in microenvironment during remodeling cycle, we have investigated effects of matrix and some its constituents on IL-1 secretin from peripheral blood (PBMC). Increases activity were observed when either PBMC or adherent monocytes, but not lymphocytes depleted co-cultured with human rat particles latex similar size. Co-culture a transwell system where physically separated...
• Numerous anatomic and physiologic alterations occur in the kidney with aging. These changes affect ability of elderly patient(s) to maintain homeostasis alter response medications, stress, illness, or diet, mobility, environment. Drug-induced illness drug interactions are major problems elderly. Bone disease fractures associated negative calcium balance decreased production 1,25-dihydrocholecalciferol seen The geriatric patient is not immune primary glomerular diseases that younger...
The issue of the direct action glucocorticoids on bone resorption was addressed in a model system consisting pure (99%) population putative osteoclast precursors, namely thioglycollate-elicited rat macrophages cocultured vitro with devitalized particles which had been prelabeled vivo 45Ca. After 4 days culture, these mobilized net 20–30% 45Ca from bone. addition cortisol physiological concentrations (10-8 M) elicited significant (P < 0.001) increases isotope mobilization; optimal enhancement...
Surgical trauma care requires excellent multidisciplinary team skills and communication to ensure the highest patient survival rate. This study investigated effects of Hyper-realistic immersive surgical training improve individual performance. A environment is defined as having a high degree fidelity in replication battlefield conditions environment, so participants willingly suspend disbelief that they become totally immersed eventually stress inoculated way can be measured physiologically.
MALONE, JOHN D. MD; HYAMS, KENNETH C. MD, MPH; HAWKINS, RICHARD E. SHARP, TRUEMAN W. DANIELL, FREDRIC MPH Author Information
As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing infeasible at scale, especially in areas with limited resources, participation, or testing/sequencing capacity, which can also introduce biases. RNA concentration wastewater successfully tracks regional infection dynamics provides less biased abundance estimates than testing. Tracking virus genomic sequences would...
1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) induces monocytic differentiation of the human promyelocytic leukemia line, HL-60, and enhances Ca2+ transport in target cells mineral metabolism system. Hence, we determined whether steroid's maturational effect on HL-60 involves alterations intracellular calcium [(Ca2+]i). We found that, as detected by indo-1 fluorescence, [Ca2+]i increases a slow tonic manner from 99 +/- 11 nM virgin to 182 19 (p less than 0.001) those treated with 1,25-(OH)2D3 for...
Journal Article Risk of Viral Hepatitis among Military Personnel Assigned to US Navy Ships Get access Richard E. Hawkins, Hawkins Reprints or correspondence: Dr. Hawkins. Infectious Disease Division, National Naval Medical Center, Bethesda. MD 20889-1000. Search for other works by this author on: Oxford Academic PubMed Google Scholar John D. Malone, Malone Lee A. Cloninger, Cloninger Patrick J. Rozmajzl, Rozmajzl Drew Lewis, Lewis James Butler, Butler Eleanor Cross, Cross Stephanie Gray,...
Objective: The primary aim of this study was to describe high support accommodation services available for patients with chronic mental illness living in New South Wales (NSW). second ask these facilities about their needs and satisfaction assess level functioning. Method: Non-inpatient matching NSW Health's definition support, very residential rehabilitation were sent a survey regarding type service, criteria acceptance, choice housing options, patient demographics, evaluation methods staff...
Human peripheral mononuclear cells responded chemotactically to 4-carboxyl-L-glutamic acid. The maximal chemotactic response occurred at 0.1 nM. No was found with neutrophils or fetal bovine fibroblasts. Glutamic acid, a neuroexcitatory dicarboxylic amino acid and the parent compound of 4-carboxyglutamic did not stimulate chemotaxis in any tested. However, it functioned as an antagonist (ED50 approximately 2 pM; ED100 10 pM). In contrast lack glutamic its cyclic analogue, kainic excited...
To determine whether military personnel deployed outside the United States are at increased risk of Helicobacter pylori infection, 1,000 male U.S. Navy and Marine Corps (mean age 22 years) were evaluated. Study subjects included 200 recruits, 500 shipboard for six months to South America, West Africa, Mediterranean, 300 ground troops five Saudi Arabia. Among all subjects, 247 (25%) seropositive H. IgG antibody by an enzyme-linked immunosorbent assay; 24% new recruits 25% who had been on...
During the process of enhancing monocytic differentiation human leukemia line HL-60, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) also primes cell for respiratory burst by increasing uptake Ca2+ across plasma membrane (Hruska, K.A., Bar-Shavit, Z., Malone, J.D., and Teitelbaum, S.L. (1988) J. Biol. Chem. 263, 16039-16044). The present study asked if maturational effect vitamin D is dependent upon this priming phenomenon. To end, we exposed HL-60 to either 1,25(OH)2D3 or its synthetic analogue (1...
Volunteers in a natural history study of human immunodeficiency virus type 1 (HIV-1) at two military medical centers were studied to determine whether plasma HIV-1 RNA levels differ among racial and ethnic groups US adults infected with HIV-1. Cross-sectional analyses CD4 cell counts done using demographic clinical data collected during visits. Age, gender, count, seroconversion status, use antiretroviral therapy 545 members (46% white, 49% black, 6% Hispanic). No association was found...