A5061776135- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Biomarkers in Disease Mechanisms
- Adipose Tissue and Metabolism
- Cellular Mechanics and Interactions
- Gout, Hyperuricemia, Uric Acid
- IL-33, ST2, and ILC Pathways
- Meningioma and schwannoma management
- Heme Oxygenase-1 and Carbon Monoxide
- Microtubule and mitosis dynamics
- Melanoma and MAPK Pathways
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Neurofibromatosis and Schwannoma Cases
- Intracranial Aneurysms: Treatment and Complications
- Biochemical effects in animals
- RNA Interference and Gene Delivery
- Nuclear Receptors and Signaling
- Aldose Reductase and Taurine
- Traumatic Brain Injury and Neurovascular Disturbances
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Extracellular vesicles in disease
- Renal Diseases and Glomerulopathies
- Head and Neck Surgical Oncology
Xuzhou Medical College
2012-2023
Nanjing Drum Tower Hospital
2020-2023
Abstract Background Adiponectin is an adipocytokine that plays a key regulatory role in glucose and lipid metabolism obesity. The prevalence of obesity has led to increase the incidence obesity-related glomerulopathy (ORG). This study aimed identify protective adiponectin ORG. Methods Small-interfering RNA (siRNA) against gene encoding was transfected into podocytes. oxidative stress level determined using fluorometric assay. Apoptosis analyzed by flow cytometry. expressions podocyte markers...
Diabetic nephropathy (DN) is one of the most common complications diabetes. Gradual loss podocytes a sign DN and pyroptosis mechanistically correlates with podocyte injury in DN; however, mechanism(s) involved remain unknown. Here we reveal that TRIM29 overexpressed high glucose (HG)-treated murine cells silencing significantly inhibits damage due to HG treatment, as evidenced by lower desmin expression greater nephrin expression. Additionally, flow cytometry analysis showed inhibited...
Pineal region meningiomas are deeply located and adjacent to critical neurovascular structures, making them one of the most challenging areas access. The authors presented a combined microscopic endoscopic surgery investigated its value in resecting pineal meningiomas. Twelve patients with from February 2017 December 2020 were retrospectively reviewed. All underwent using occipital-parietal transtentorial approach. Perioperative clinical, surgical, radiographic data collected. endoscope...
Increasing evidence indicates that early brain injury (EBI) can contribute to poor outcomes following subarachnoid hemorrhage (SAH), and is associated with apoptosis. Cyclin-dependent kinase 5 (Cdk5) a key mediator of neuronal viability. The role Cdk5 in several neurological disorders has been elucidated; however, its EBI after SAH remains unclear. present study aimed explore the involvement SAH. expression levels Cdk5, phosphorylated at Tyr15 (Cdk5-pTyr15) p25 (a activator) were assessed by...
Glioma is one of the malignancy brain tumors, which deeply threaten health patients. Although traditional therapies for glioma have improved, outcome still far from satisfactory. Bone Marrow Stromal Cells (BMSC)-based therapy provided novel insight in treatment glioma. However, detailed molecular mechanism not clear. The aim present study to discover factor BMSC-based cell proliferation and apoptosis were identified by using CCK-8 flow cytometry. invasion cells was examined Transwell assay...
Introduction The aim of this study is to explain the effects and mechanisms Nur77 in glioma development. Material methods protein gene expression were measured by immunohistochemistry real-time quantitative polymerase chain reaction (RT-qPCR) tissues from craniocerebral injury patients. patients divided into two groups according median correlations between clinical pathology, progression-free survival (PFS), overall (OS), analysed. U257 U87 cells employed assess cancer cell development MTT,...