A5101802738- Bone Metabolism and Diseases
- Bone health and treatments
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Spine and Intervertebral Disc Pathology
- Bone Tumor Diagnosis and Treatments
- Estrogen and related hormone effects
- Sarcoma Diagnosis and Treatment
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Vitamin D Research Studies
- Management of metastatic bone disease
- RNA modifications and cancer
- Musculoskeletal pain and rehabilitation
- Radiopharmaceutical Chemistry and Applications
- Ion channel regulation and function
- biodegradable polymer synthesis and properties
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Parasitic infections in humans and animals
- Reproductive System and Pregnancy
- Hip and Femur Fractures
- Additive Manufacturing and 3D Printing Technologies
- Nuclear Structure and Function
- NF-κB Signaling Pathways
Huazhong University of Science and Technology
2018-2025
Tongji Hospital
2018-2025
Zhengzhou University
2022
Henan Provincial People's Hospital
2022
Wuhan Institute of Technology
2021
Study Design. A retrospective cohort study. Objective. The authors aimed to estimate the incidence, prevalence and years lived with disability (YLDs) of spinal cord injury (SCI) by location, sex, age, site socio-demographic index (SDI) based on data Global Burden Disease (GBD) 2019. Summary Background Data. GBD 2019 estimates burden 369 diseases injuries worldwide in temporal trends past 30 years. SCI is estimated as a result from various causes. Methods. Bayesian meta-regression tool,...
Abstract Background Hip fractures are associated with a high risk of death; among those who survive hip fracture, many experience substantial decreases in quality life. A comprehensive understanding the epidemiology and burden by country, age, gender, sociodemographic factors would provide valuable information for healthcare policymaking clinical practice. The Global Burden Disease (GBD) study 2019 was global-level estimating 369 diseases injuries 204 countries territories. An exploration...
Objective We aim to explore the global spatial prevalence and temporal trends of burden low bone mineral density (LBMD) worldwide, due a lack related studies. Design Cross-sectional study. Methods used data from Global Burden Disease Study 2019 conduct this LBMD in GBD study includes both osteopenia osteoporosis. The estimation for prevalence, measured by summary exposure value (SEV), was made DisMod-MR 2.1, Bayesian meta-regression tool. Correlation analysis performed using Spearman rank...
Abstract Osteoporosis is a degenerative bone disease resulting from homeostasis imbalance regulated by osteoblasts and osteoclasts. Treating osteoporotic defects tends to be more difficult due suppressed osteogenic differentiation, hyperactive osteoclastogenesis, impaired angiogenesis. Hence, drug carrier system composed of gelatin‐coated hollow mesoporous silica nanoparticles (HMSNs/GM) loaded with pro‐osteogenic parathyroid (PTH) anti‐osteoclastogenic alendronate (ALN) constructed...
Abstract Osteoclasts consume an amount of adenosine triphosphate (ATP) to perform their bone resorption function in the development osteoporosis. However, mechanism underlying osteoclast energy metabolism has not been fully elucidated. In addition glucose, glutamine (Glu) is another major carrier produce ATP. role Glu osteoclasts and related molecular mechanisms poorly Here we show that required for differentiation function, deprivation or pharmacological inhibition transporter ASCT2 by...
Bone infection is one of the most devastating orthopedic outcomes, and overuse antibiotics may cause drug-resistance problems. Photothermal therapy(PTT) a promising antibiotic-free strategy for treating infected bone defects. Considering damage to normal tissues cells caused by high-temperature conditions in PTT, this study combines antibacterial property Cu construct multi-functional
Neck pain and low back are two of the major diseases, which causes patients a quantify life heavy economic burden, intervertebral disc degeneration (IDD) contributes to them, mechanism is not totally clear. The increased inflammatory cytokines including interleukin (IL)-1β tumor necrosis factor (TNF)α downstream signaling pathways involved. Inositol requiring enzyme 1 (IRE1) crucial that regulates endoplasmic reticulum (ER) stress. It reported IRE1 plays an important role in activation...
Low back pain (LBP) is a common worldwide disease that causes an enormous social economic burden. Intervertebral disc degeneration (IDD) considered as major cause of LBP. The process IDD complicated and involves both inflammation senescence. production pro-inflammatory cytokines, including tumor necrosis factor (TNF)α interleukin (IL)-1β, increased in the degenerating intervertebral disc, inducing extracellular matrix degradation. Urolithin A (UA) metabolite compound resulting from...
ABSTRACT ATP-citrate lyase (ACLY), generating most of the nucleocytosolic acetyl coenzyme A (acetyl-CoA) for histone acetylation, links cell metabolism to epigenetic regulation. Recent investigations demonstrated that ACLY activated by metabolic reprogramming played an essential role in both M1 and M2 macrophage activation via acetylation. Previous studies also revealed methylation acetylation were critical transcriptional regulation osteoclast-specific genes. Considering osteoclast...
Osteosarcoma (OS) is the most common primary bone tumor, whose poor prognosis mainly due to lung metastasis.The aim of this study build a practical and valid diagnostic test that can predict risk OS metastasis progression.We performed weighted gene co-expression network analysis (WGCNA) on GSE21257 from Gene Expression Omnibus (GEO) database, which contains microarray data biopsies patients.In these modules, highest association was found between blue module stage (r = -0.52)by Pearson's...
Due to the unique physical characteristics of intervertebral disc degeneration (IVDD) and pathological microenvironment that it creates, including inflammation oxidative stress, effective self-repair is impossible. During process degeneration, there an increase in infiltration M1 macrophages secretion proinflammatory cytokines. Here, we designed a novel injectable composite hydrogel scaffold: oligo [poly (ethylene glycol) fumarate]/sodium methacrylate (OPF/SMA) scaffold loaded with...
Bone homeostasis is maintained by osteoclast-mediated bone resorption and osteoblast-mediated formation. A dramatic decrease in estrogen levels postmenopausal women leads to osteoclast overactivation, impaired homeostasis, subsequent loss. Changes the gut microbiome affect mineral density. However, role of deficiency-induced loss its underlying mechanism remain unknown. In this study, we found that abundance Clostridium sporogenes (C. spor.) derived metabolite, indole propionic acid (IPA),...
Biodegradable scaffolds based on biomedical polymeric materials have attracted wide interest in bone transplantation for clinical treatment defects without a second operation. The composite of poly(trimethylene carbonate), poly(L-lactic acid), and hydroxyapatite (PTMC/PLA/HA PTMC/HA) were prepared by the modification blending PTMC with PLA HA, respectively. PTMC/PLA/HA PTMC/HA further additive manufacturing using biological 3D printing method materials, These also characterized Fourier...
Bone metastasis is a severe complication associated with various carcinomas. It causes debilitating pain and pathologic fractures dramatically impairs patients' quality of life. Drugs aimed at osteoclast formation significantly reduce the incidence skeletal complications are currently standard treatment for patients bone metastases. Here, we reported that serum- glucocorticoid-inducible kinase 1 (SGK1) plays pivotal role in function osteoclasts by regulating Ca
3D Printed biodegradable polymeric scaffolds are critical to repair a bone defect, which can provide the individual porous and network microenvironments for cell attachment tissue regeneration. Biodegradable PCL/HA composites were prepared with blending of poly(ε-caprolactone) (PCL) hydroxyapatite nanoparticles (HA). Subsequently, produced by melting deposition-forming method using as raw materials in this work. Through serial vitro assessments, it was found that possessed good...
Osteoporosis is a systemic skeletal disease which highly prevalent worldwide and considered to be associated with excessive bone resorption mediated by osteoclast. Osteoclast differentiation characterized the activation of inflammation-related pathways generation reactive oxygen species (ROS). Schisandrin B bioactive compound strong anti-inflammation anti-oxidative properties, we thus speculated that might serve as potential candidate for osteoporosis. In present study, found formation...
Regional lymph node metastasis (RLNM) has been reported to be a prognostic factor for poor survival outcomes of bone sarcoma. However, studies about risk factors RLNM sarcoma are extremely rare, and the outcome such patients remains explored. We aimed identify conduct analysis with RLNM.A total 10,641 confirmed malignant sarcomas from 1983 2014 were identified Surveillance, Epidemiology, End Results (SEER) database, 311 being regional positive. Logistic regression was used RLNM, while Cox...
Osteoclasts are multinucleated cells derived from the monocyte/macrophage cell lineage under regulation of receptor activator nuclear factor-κB ligand (RANKL). In previous studies, stimulation by RANKL during osteoclastogenesis was shown to induce a metabolic switch enhanced glycolytic metabolism. Thus, we hypothesized that blockage glycolysis might serve as novel strategy treat osteoclast-related diseases. present study, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), an...