A5089752490- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Viral Infections and Vectors
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Vector-Borne Animal Diseases
- Streptococcal Infections and Treatments
- Animal Virus Infections Studies
Shihezi University
2017-2025
Xinjiang Production and Construction Corps
2017-2024
South China Agricultural University
2014-2021
Key Laboratory of Guangdong Province
2017
Abstract Human infections with avian influenza H7N9 or H10N8 viruses have been reported in China, raising concerns that they might cause human epidemics and pandemics. However, how these adapt to mammalian hosts is unclear. Here we show besides the commonly recognized viral polymerase subunit PB2 residue 627 K, other residues including 87E, 292 V, 340 588 648 V 676 M also play critical roles adaptation of virus. The avian-origin H10N8, H9N2 harboring PB2-588 exhibited higher activity, more...
Porcine transmissible enteritis virus (TGEV) is a fatal pathogen affecting newborn piglets, presenting significant challenge to global intensive pig farming biosecurity due its ongoing mutation. There still lack of effective vaccines combat this virus, Vaccination has long been considered the most way overcome infectious diseases, however, traditional cannot be brought market quickly enough deal with rapid mutations and emerging viruses. Therefore, study addresses gap by using...
Wild birds play an important role in the emergence, evolution, and spread of zoonotic avian influenza viruses (AIVs). However, there are few studies on cross-species transmission H3N8 AIV originating from wild birds. In this study, we investigated transmissibility pathogenicity two low pathogenic (LPAIVs) isolated birds, GZA1 XJ47, to mammals. The HA genes both strains belonged Eurasian isolates, while other were derived a variety subtypes AIVs. Both can infect specific-pathogen-free (SPF)...
Considered an epicenter of pandemic influenza virus generation, southern China has recently seen increasing number human H7N9 infections. However, it is not the only threat. On 30 November 2013, a H10N8 infection case was first described in China. The origin and genetic diversity this novel similar to that virus. As avian (AIV) identified from duck Guangdong Province during 2012 there also evidence infected dogs region, we sought examine archived sera animal workers see if subclinical...
Avian influenza (AI) is an important zoonotic disease, which can be transmitted across species barriers to other hosts, especially humans, posing a serious threat the poultry industry and public health. In recent years, human cases infected with H10N8, H9N2, H7N9 of avian viruses (AIVs) have been identified frequently as internal genes are derived from H9N2 viruses. The adaptive mutation PB2 gene way for AIVs spread adapt new hosts. Several well-known mutations in gene, such E627K, D701N,...
African swine fever (ASF) is an acute and severe infectious disease that seriously endangers the global porcine industry. In order to develop ASF serodiagnostic reagents with high specificity sensitivity, in present study, antigenic epitopes of P72 protein virus (ASFV) were analyzed, ASFV multi-epitope fusion gene MeP72 tandem dominant linear was constructed. The recombinant (reMeP72) prepared Escherichia coli. A colloidal gold-based immunochromatographic assay (CGIA) based on reMeP72...
Considered an epicenter of pandemic influenza virus generation, southern China has recently seen increasing number human H7N9 infections. However, it is not the only threat. On 30 November 2013, a H10N8 infection case was first described in China. The origin and genetic diversity this novel similar to that virus. As avian (AIV) identified from duck Guangdong Province during 2012 there also evidence infected dogs region, we sought examine archived sera animal workers see if subclinical...