A5101423622- Liver Disease Diagnosis and Treatment
- Nuclear materials and radiation effects
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Telomeres, Telomerase, and Senescence
- Nuclear Materials and Properties
- Adipokines, Inflammation, and Metabolic Diseases
- Plant nutrient uptake and metabolism
- CRISPR and Genetic Engineering
- Aortic Disease and Treatment Approaches
- Chromosomal and Genetic Variations
- Aortic aneurysm repair treatments
- Cardiac Fibrosis and Remodeling
- Pluripotent Stem Cells Research
- Ion-surface interactions and analysis
- Tissue Engineering and Regenerative Medicine
- Eicosanoids and Hypertension Pharmacology
- Advanced Glycation End Products research
- GDF15 and Related Biomarkers
- Laser Applications in Dentistry and Medicine
- Burn Injury Management and Outcomes
- Plant Micronutrient Interactions and Effects
- Intracerebral and Subarachnoid Hemorrhage Research
- Healthcare and Venom Research
Air Force Medical University
2014-2024
Chengdu University of Technology
2024
Washington State University Spokane
2019-2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Xijing Hospital
2014-2023
Zero to Three
2023
Nanjing Agricultural University
2018-2022
University of Michigan
1993-2018
Institute of Microbiology
2011
The Western meat-rich diet is both high in protein and fat. Although the hazardous effect of a fat (HFD) upon liver structure function well recognized, whether co-presence intake contributes to, or protects against, HF-induced hepatic injury remains unclear. Increased branched chain amino acids (BCAA, essential compromising 20% total intake) reduces body weight. However, elevated circulating BCAA associated with non-alcoholic fatty disease injury. mechanisms responsible for this quandary...
The branched-chain amino acids (BCAA) accumulated in type 2 diabetes are independent contributors to insulin resistance. activity of α-keto acid dehydrogenase (BCKD) complex, rate-limiting enzyme BCAA catabolism, is reduced diabetic states, which contributes elevated concentrations. However, the mechanisms underlying decreased BCKD remain poorly understood. Here, we demonstrate that mitochondrial phosphatase 2C (PP2Cm), a newly identified increases activity, was significantly downregulated...
Nonalcoholic steatohepatitis (NASH) is closely associated with metabolic syndrome and increases the risk for end-stage liver disease, such as cirrhosis hepatocellular carcinoma. Despite this, molecular events that influence NASH pathogenesis remain poorly understood. The objectives of current study are to delineate transcriptomic proteomic signatures liver, identify potential pathogenic pathways factors, critically assess their role in pathogenesis. We performed RNA sequencing quantitative...
Branched chain amino acids (BCAAs) are associated with the progression of obesity-related metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease. However, whether BCAAs disrupt homeostasis hepatic glucose lipid metabolism remains unknown. In this study, we observed that supplementation significantly reduced high-fat (HF) diet–induced accumulation while increasing plasma levels promoting muscular renal accumulation. Further studies demonstrated increased...
Prostate cancer (PC) develops in a microenvironment where the stromal cells modulate adjacent tumor growth and progression. Here, we demonstrated elevated levels of monoamine oxidase B (MAOB), mitochondrial enzyme that degrades biogenic dietary monoamines, human PC stroma, which was associated with poor clinical outcomes patients. Knockdown or overexpression MAOB prostate fibroblasts indicated promotes cocultured cell proliferation, migration, invasion co-inoculated mice. Mechanistically,...
The farnesoid X receptor (FXR) is a member of the metabolic nuclear superfamily that plays critical regulatory role in cardiovascular physiology/pathology. However, systemic FXR activation chronic phase myocardial infarction (MI)-induced cardiac remodelling and dysfunction remains unclear. In this study, we aimed to elucidate long-term on post-MI dysfunction.Mice underwent either MI surgery or sham operation. At 1 week after MI, both mice were gavaged with 25 mg/kg/d synthetic agonist...
Macrophages are essential for wound repair after myocardial infarction (MI).CD226, a member of immunoglobulin superfamily, is expressed on inflammatory monocytes, however, the role CD226 in infarct healing and effect macrophage remain unknown.Methods: Wild type knockout (CD226 KO) mice were subjected to permanent coronary ligation.CD226 expression, cardiac function ventricular remodeling evaluated.Profile macrophages, myofibroblasts, angiogenesis monocytes mobilization determined.Results:...
DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 71:11-17 (2006) - doi:10.3354/dao071011 Quantitative relationship two viruses (MrNV and XSV) in white-tail disease Macrobrachium rosenbergii Huajun Zhang1, Jianmin Wang1, Junfa Yuan1, Lijuan Li1, Jianhong Jean-Robert Bonami2, Zhengli Shi1,* 1State Key Laboratory Virology, Wuhan Institute Chinese Academy Sciences,...
Abstract Background and Aim It has been well documented that Notch signaling is involved in liver regeneration. However, the exact molecular mechanism mediating this process not fully elucidated. The current study aimed to investigate role of regulating cell cycle proliferating hepatocytes regeneration after partial hepatectomy (PHx, 67% resection) related mechanism. Methods Partial was performed Sprague Dawley rats, remnant livers were harvested 0, 1, 3, 5, 7 days operation, primary...
The incidence of heart failure mainly resulting from cardiac hypertrophy and fibrosis increases sharply in post-menopausal women compared with men at the same age, which indicates a cardioprotective role estrogen. Previous studies our group have shown that novel estrogen receptor G Protein Coupled Receptor 30 (GPR30) could attenuate myocardial caused by ischemic disease. However, GPR30 ovariectomized mice has not been investigated yet. In this study, female bilateral ovariectomy or sham...
ObjectivesAcute type A aortic dissection (ATAAD) with severe stenosis or occlusion of the true lumen arch branch vessels often leads to an increased incidence postsurgical neurological complications and mortality rate. In this study, we aimed introduce our institutional extra-anatomic revascularization cannulation strategy improved postoperative outcomes for better management patients cerebral malperfusion in setting ATAAD.MethodsTwenty-eight ATAAD complicated by vessels, as noted on...
Abstract Telomerase is expressed in adult mouse, but not most human, tissues and mouse telomeres are much longer than those humans. This interspecies difference of telomere homeostasis poses a challenge modeling human diseases using laboratory mice. Using chromatinized bacterial artificial chromosome reporters, we discovered that the 5′ intergenic region, introns 2 6 telomerase gene ( hTERT ) were critical for regulating its promoter somatic cells. Accordingly, engineered humanized gene,...
Abstract Telomerase activation is a crucial step in melanomagenesis, often occurring because of ultraviolet radiation (UVR)‐induced mutations at the telomerase gene ( TERT ) promoter and rendering transcription response to activated Raf‐MAP kinase pathway by BRAF V600E mutation. Due excessively long telomeres mice, this process does not occur during melanomagenesis mouse models. To investigate impact telomere dysfunction on Braf was induced generations 1 4 (G1 G4) Tert −/− mice. Our findings...
Summary Nitric oxide is a potent anti‐apoptotic and cardioprotective molecule in healthy animals. However, recent study demonstrates that overexpression of eNOS exacerbates the liver injury diabetic whether diabetes may also alter NO 's biologic activity ischaemic/reperfused heart remains unknown. The present experiment was designed to determine nitric donor, S‐nitrosoglutathione, exert different effects on non‐diabetic myocardial ischaemia/reperfusion ( MI /R) injury. Diabetic state induced...
Significance Repetitive DNA sequences are abundant in the human genome, and their high variabilities contribute to genetic diversity disease susceptibility. Here, we report that an intronic variable number tandem repeat element, VNTR2-1, is critical for transcription of telomerase reverse transcriptase ( hTERT ) gene a cell-context–dependent manner. Removal this element at its native genomic site cancer cells resulted telomere shortening, cellular senescence, impaired tumor growth. VNTR2-1...
ABSTRACT Mitochondrial damage is an important cause of heart dysfunction after severe burn injury. However, the pathophysiological process remains unclear. This study aims to examine mitochondrial dynamics in and role μ-calpain, a cysteine protease, this scenario. Rats were subjected injury treatment, calpain inhibitor MDL28170 was administered intravenously 1 h before or group displayed weakened performance decreased mean arterial pressure, which accompanied by diminishment function. The...
NLRP3 inflammasome mediates myocardial ischemia/reperfusion (MI/R) injury and diabetic vascular endothelia dysfunction. However, the role of in MI/R with diabetes has not been fully described. Irisin plays an important anti-inflammation improves endothelial function type 2 diabetes. The current study aimed to investigate effect irisin on regulating activation dysfunction.Cardiac microvascular cells (CMECs) were cultured subjected high glucose/high fat (HG/HF) receiving hypoxia/reoxygenation...