A5100621119- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Prostate Cancer Treatment and Research
- Diagnosis and treatment of tuberculosis
- Immune responses and vaccinations
- Hippo pathway signaling and YAP/TAZ
- Lung Cancer Treatments and Mutations
- Pneumocystis jirovecii pneumonia detection and treatment
- Receptor Mechanisms and Signaling
- Cancer Immunotherapy and Biomarkers
- Healthcare Systems and Reforms
- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Adenosine and Purinergic Signaling
- Chemical Reactions and Isotopes
- Angiogenesis and VEGF in Cancer
- Bacteriophages and microbial interactions
- Alcohol Consumption and Health Effects
- Cancer Treatment and Pharmacology
- Oral health in cancer treatment
- Myofascial pain diagnosis and treatment
- Advanced Breast Cancer Therapies
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
Beijing Chest Hospital
2023-2025
Capital Medical University
2023-2025
NARI Group (China)
2025
Bengbu Medical College
2023-2024
Washington State University Spokane
2021-2024
First Affiliated Hospital of Bengbu Medical College
2024
Nanchang University
2021-2023
Sichuan University
2022-2023
West China Hospital of Sichuan University
2023
Second Affiliated Hospital of Nanchang University
2023
The World Health Organization (WHO) “Global Tuberculosis Report 2024” underscores the ongoing challenges and progress in global fight against tuberculosis (TB). Despite a slowdown annual increase TB cases decline TB-related deaths, disease remains significant public health threat with 10.8 million new reported 2023. report reveals persistently high burden of TB, especially low- middle-income countries, highlights escalating issue drug-resistant TB. also emphasizes critical need for increased...
Earlier evidence has proven that probiotic supplements can reduce concurrent chemoradiotherapy (CCRT)-induced oral mucositis (OM) in nasopharyngeal cancer (NPC). The incidence of severe OM (grade 3 or higher) was the primary endpoint this study. We first enrolled 85 patients with locally advanced NPC who were undergoing CCRT. Of them, 77 finally selected and randomized (1:1) to receive either a cocktail placebo. To investigate protective effects mechanism treatment on induced by radiotherapy...
Prostate cancer (PC) develops in a microenvironment where the stromal cells modulate adjacent tumor growth and progression. Here, we demonstrated elevated levels of monoamine oxidase B (MAOB), mitochondrial enzyme that degrades biogenic dietary monoamines, human PC stroma, which was associated with poor clinical outcomes patients. Knockdown or overexpression MAOB prostate fibroblasts indicated promotes cocultured cell proliferation, migration, invasion co-inoculated mice. Mechanistically,...
This study aimed to evaluate the efficacy and safety of an all-oral short-term regimen for treating multidrug-resistant tuberculosis (MDR-TB). In this semirandomized, controlled, multicenter clinical study, patients with MDR-TB who were sensitive fluoroquinolones assigned treatment groups at enrollment. Patients group C (4-6 months: bedaquiline + linezolid clofazimine moxifloxacin cycloserine; 5 cycloserine) unless protocol was unsuitable or unacceptable, in which case they randomly A...
Abstract Androgen receptor (AR) is the primary oncogenic driver of prostate cancer, including aggressive castration-resistant cancer (CRPC). The molecular mechanisms controlling AR activation in general and reactivation CRPC remain elusive. Here we report that monoamine oxidase A (MAOA), a mitochondrial enzyme degrades neurotransmitters dietary amines, reciprocally interacts with cancer. MAOA was induced by androgens through direct binding to novel intronic androgen response element gene,...
Bedaquiline (BDQ) is a potent drug for treating drug-resistant tuberculosis (TB). Here, we analysed the resistance profiles of BDQ in CFZ-resistant clinical isolates and investigated risk factors CFZ cross/co-resistance.The AlarmarBlue microplate assay was performed to determine minimum inhibitory concentration (MIC) Mycobacterium (MTB) BDQ. The characteristics respective patients were explore possible resistance. drug-resistance-associated genes including Rv0678, Rv1979c, atpE, pepQ Rv1453...
Tuberculosis is an important chronic and often fatal infectious disease mainly caused by the bacterium Mycobacterium tuberculosis (Mtb). Mtb one of most successful pathogens that harbors several potential virulence factors not found in nonpathogenic mycobacteria. As cell envelope closely associated with its resistance, it very to understand for better treatment causative pathogen. There increasing evidence Pro-Glu (PE) Pro-Pro-Glu (PPE) proteins are major effectors persistence encoded H37Rv...
Abstract Background: Therapy resistance in cancer is often linked to cell state or lineage changes. In prostate (PCa), a subset of castration-resistant (CRPC) loses reliance on the androgen receptor (AR) signaling and gains neuroendocrine (NE) traits through switch along disease progression. However, molecular mechanisms driving such cellular plasticity remain unclear. This study investigated functional mechanistic role monoamine oxidase A (MAOA) adenocarcinoma (adeno)-to-NE conversion CRPC...
Abstract Background Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) is a peptide released from the mycobacterial cytoplasm into supernatant of (Mtb) attenuated H37Ra strain after autoclaving at 121 °C for 20 min. Mtb-HAg can specifically induce γδ T-cell proliferation in vitro. However, exact composition and protein antigens that are responsible its function currently unknown. Methods extracted Mtb was subjected to LC‒MS mass spectrometry. Twelve identified fractions were...
SQ109 is a promising candidate drug for the treatment of patients with drug-resistant tuberculosis (DR-TB). The purpose this study was to investigate activity against clinical isolates Mycobacterium (MTB) from multidrug-resistant TB (MDR-TB) and pre-extensively (pre-XDR-TB), explore new mechanisms SQ109.
Objective: To establish the diagnostic concentration range of urine cystatin C and control level for patients with renal injury, to help promote establishment standardization detection. Methods: 150 specimens blood from kidney injury healthy people were collected, stored in refrigerator at -80°C later use. After they uniformly tested. Comparing difference between group group, application value diagnosis treatment was put forward. Results: The concentrations 1.04 ± 2.14 mg/L 1.94 2.36...
Abstract Background Intrauterine adhesion (IUA) is a frequent acquired endometrial condition, for which there no effective preventive or treatment. Previous studies have found that vaginal microbiota dysregulation closely related to fibrosis and IUA. Results In this study, we administered Lactobacillus crispatus ( L. ) vaginally restore explore the beneficial role of probiotics in treatment prevention Then, created mechanically injured mouse model IUA restored mice's by addition convolvulus....
<div>Abstract<p>Androgen receptor (AR) is the primary oncogenic driver of prostate cancer, including aggressive castration-resistant cancer (CRPC). The molecular mechanisms controlling AR activation in general and reactivation CRPC remain elusive. Here we report that monoamine oxidase A (MAOA), a mitochondrial enzyme degrades neurotransmitters dietary amines, reciprocally interacts with cancer. MAOA was induced by androgens through direct binding to novel intronic androgen...