A5101793731- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Vitamin D Research Studies
- Liver Disease Diagnosis and Treatment
- Bone health and treatments
- Stellar, planetary, and galactic studies
- Liver Disease and Transplantation
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Astronomy and Astrophysical Research
- Hepatitis B Virus Studies
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Astrophysics and Star Formation Studies
- Connective tissue disorders research
- Pregnancy and preeclampsia studies
- Reproductive tract infections research
- Birth, Development, and Health
- Pharmacological Effects of Natural Compounds
- Cardiac Arrest and Resuscitation
- Gamma-ray bursts and supernovae
- Genetic Associations and Epidemiology
- Reproductive System and Pregnancy
- Simulation-Based Education in Healthcare
Integrated Chinese Medicine (China)
2024-2025
Nanchang University
2024
Third Affiliated Hospital of Nanchang University
2024
Zunyi Medical University
2020-2024
Shanghai Eye Disease Prevention & Treatment Center
2022-2024
Shanghai Jiao Tong University
2009-2024
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2023-2024
Jinshan Hospital of Fudan University
2024
Shanghai First People's Hospital
2022-2024
Jiangxi University of Traditional Chinese Medicine
2024
Alpha-fetoprotein (AFP) is a well-established biomarker for hepatocellular carcinoma (HCC). Here, we investigated the acetylation state of AFP in vivo. was regulated by acetyltransferase CBP and deacetylase SIRT1. Acetylation at lysines 194, 211, 242 increased stability protein decreasing its ubiquitination proteasomal degradation. promoted oncogenic role blocking binding to phosphatase PTEN pro-apoptotic caspase-3, which signaling proliferation, migration, invasion decreased apoptosis. High...
Abstract Background Icaritin, an active ingredient of the Chinese herb Epimedium, plays anti-tumor role in liver cancer by inhibiting proliferation hepatocellular cells and promoting their apoptosis. In China, phase II a large III clinical trial icaritin reagent for treatment is under-going, but specific mechanism action was unclear. Alpha-fetoprotein (AFP), oncofetal protein, produced healthy fetal yolk sac. Intracellular AFP promoted cellular inhibited apoptosis carcinoma (HCC). The study...
Female genital tract infection with high-risk human papilloma virus (HR-HPV) has the risk of developing into cervical cancer, and there is still a lack effective therapeutic strategies. Probiotic intervention considered as potential for HR-HPV, while exploration living probiotic preparations specific diseases remains limited insufficient. This prospective controlled pilot study was conducted to observe effect intravaginal transplantation vaginal isolated natural strain,
Abstract Background Diabetes mellitus (DM) is a progressive disease that involves multiple organs due to increased blood glucose, and diabetic retinopathy (DR) the main complication of DM in eyes causes irreversible vision loss. In pathogenesis vascular disease, oxidative stress caused by hyperglycemia plays an important role Müller cell impairment. recent years, AdipoRon, adiponectin analog demonstrated physiological functions obesity, diabetes, inflammation, cardiovascular diseases,...
Abstract Background The Wnt/beta-catenin signaling pathway plays an important role in skeletal development. Polymorphisms of frizzled-related protein (FRZB), antagonist this pathway, may generate variations bone mineral density (BMD). In study, we analyzed the association between FRZB genotypes and peak BMD variation spines hips two relatively large samples Chinese female-offspring male-offspring nuclear families. Methods We recruited 1,260 subjects from 401 families 1,296 427 genotyped four...
Abstract To identify the susceptibility genes for osteoporotic fracture in postmenopausal Chinese women, a two-stage case-control association study using joint analysis was conducted 1046 patients with nontraumatic vertebra, hip, or distal radius fractures and 2303 healthy controls. First, 113 single-nucleotide polymorphisms (SNPs) 16 potential osteoporosis candidate reported recent genomewide studies, meta-analyses large-scale functional studies were genotyped small-sample-size subgroup...
Sepsis-associated cardiac dysfunction results in increased mortality. Hyperoside (Hyp) is a flavonoid, showing significant anti-inflammatory effects. However, its pharmacological effects on sepsis-induced remain unknown. In this study, we attempted to explore whether Hyp could prevent and underlying mechanisms. We established mice mode of sepsis by cecal ligation puncture (CLP) treatment, constructed cell model myocardial injury lipopolysaccharide (LPS) stimulation. The function indicators...
Low serum 25-hydroxyvitamin D (25OHD) is associated with osteoporosis and osteoporotic fracture, but it remains uncertain whether these associations are causal. We conducted a Mendelian randomization (MR) study of 1,824 postmenopausal Chinese women to examine the detected between 25OHD bone mineral density (BMD) metabolism markers were In observational analyses, total was positively BMD at lumbar spine (P = 0.003), femoral neck 0.006) hip 0.005), inversely intact parathyroid hormone (PTH)...
To explore the long-term effect of intelligent first-aid training based on virtual reality (VR) technology cardiopulmonary resuscitation (CPR) skill proficiency. The convenience sampling method was used to select a total 100 non-medical volunteers from Nanchang, China, and this cohort randomized either VR group (VR group) or traditional simulation scenario (traditional group). Relevant data were collected for comparative analysis. Participants evaluated by measuring mean chest compression...
We report the detections of two substellar companions orbiting around evolved intermediate-mass stars from precise Doppler measurements at Subaru Telescope and Okayama Astrophysical Observatory. HD 145457 is a K0 giant with mass 1.9 M_sun has planet minimum m_2sini=2.9 M_J period P=176 d eccentricity e=0.11. 180314 also 2.6 hosts companion m_2sin i=22 M_J, which falls in brown-dwarf regime, an orbit P=396 e=0.26. b one innermost planets seventh candidate brown-dwarf-mass found stars.
The aims of this study were as follows: 1) to evaluate the association serum sclerostin with bone mineral density (BMD) and markers metabolism in postmenopausal Chinese women 2) observe relationships single-nucleotide polymorphisms (SNPs) within (SOST) gene sclerostin, BMD, metabolism.A cross-sectional was conducted 703 women. Ten tagging SNPs (rs1234612, rs1513670, rs1634330, rs1708635, rs2023794, rs7220711, rs74252774, rs851057, rs851058, rs865429) SOST genotyped. Serum measured, including...
Genome instability is a common feature of tumor cells, and the persistent presence genome potential mechanism tumorigenesis. The E3 ubiquitin ligase MDM2 intimately involved in instability, but its mechanisms are unclear. Our data demonstrated that transcription factor HBP1 target MDM2. facilitates proteasomal degradation by ubiquitinating HBP1, regardless p53 status, thus attenuating transcriptional inhibition expression genes, such as DNA methyltransferase DNMT1 histone EZH2, which results...
Golgi protein 73 (GP73) and alpha fetoprotein (AFP) serve as biomarkers for the diagnosis of hepatocellular carcinoma (HCC), their serum levels correlate with patients' outcomes. However, mechanisms underlying these correlations are unknown. Here we show that GP73 increased secretion AFP through direct binding to AFP, thereby promoting proliferation metastasis HCC cells expressed its receptor (AFPR). Extracellular contributed independent AFPR. Moreover, extracellular synergized enhance...
Stellar parameters for large samples of stars play a crucial role in constraining the nature and stellar populations Galaxy. An increasing number medium-band photometric surveys are presently used estimating parameters. In this study, we present machine-learning approach to derive estimates parameters, including [Fe/H], logg, Teff, based on combination broad-band observations. Our analysis employs data primarily sourced from SAGE Survey , which aims observe much Northern Hemisphere. We...
The association between autoimmune thyroid disease and cancer remains unclear. We performed a matched case-control study to assess the Hashimoto's thyroiditis papillary microcarcinoma (PTMC). A total of 927 PTMC cases age- gender- controls selected from same population were recruited. Odds ratio (OR) with 95% confidence interval (95% CI) was used strength PTMC. Conditional logistic regression analysis carried out, stratified analyses by age, gender types antibodies also performed....
Abstract Background Intrauterine adhesion (IUA) is a frequent acquired endometrial condition, for which there no effective preventive or treatment. Previous studies have found that vaginal microbiota dysregulation closely related to fibrosis and IUA. Therefore, we wondered whether restoration of by administration L. crispatus could prevent ameliorate Results First, created mechanically injured mouse model IUA restored the mice’s addition convolvulus. The observations suggested intrauterine...
We aim at deriving accurate atmospheric parameters and chemical abundances of 19 barium (Ba) stars, including both strong mild Ba based on the high signal-to-noise ratio resolution Echelle spectra obtained from 2.16 m telescope Xinglong station National Astronomical Observatories, Chinese Academy Sciences. The sample stars were an LTE, plane-parallel line-blanketed model by inputting (effective temperatures, surface gravities, metallicity microturbulent velocity) equivalent widths stellar...