A5100617032- Immune Cell Function and Interaction
- Spine and Intervertebral Disc Pathology
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Musculoskeletal pain and rehabilitation
- Chronic Lymphocytic Leukemia Research
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Viral-associated cancers and disorders
- Spinal Hematomas and Complications
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Leadership, Courage, and Heroism Studies
- Pharmacological Effects of Natural Compounds
- Gastrointestinal Tumor Research and Treatment
- Urticaria and Related Conditions
- Tendon Structure and Treatment
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Medical Imaging and Analysis
- Diabetic Foot Ulcer Assessment and Management
First Affiliated Hospital of Anhui Medical University
2024-2025
Hefei First People's Hospital
2024-2025
Anhui Medical University
2025
Xinqiao Hospital
2021-2024
Shantou University Medical College
2023
Army Medical University
2021-2023
Shantou University
2023
Chinese PLA General Hospital
2022-2023
Beijing Union University
2023
Tianjin Medical University Cancer Institute and Hospital
2018-2022
Branched chain amino acids (BCAAs) are associated with the progression of obesity-related metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease. However, whether BCAAs disrupt homeostasis hepatic glucose lipid metabolism remains unknown. In this study, we observed that supplementation significantly reduced high-fat (HF) diet–induced accumulation while increasing plasma levels promoting muscular renal accumulation. Further studies demonstrated increased...
Abstract Purpose: To explore the potential of ex vivo expanded healthy donor–derived allogeneic CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia patients. Experimental Design: Clinical-grade DNTs from peripheral blood donors were their antileukemic activity safety examined using flow cytometry–based in vitro killing assays xenograft models against AML patient blasts hematopoietic cells. Mechanism action was investigated antibody-mediated blocking...
The farnesoid X receptor (FXR) is a member of the metabolic nuclear superfamily that plays critical regulatory role in cardiovascular physiology/pathology. However, systemic FXR activation chronic phase myocardial infarction (MI)-induced cardiac remodelling and dysfunction remains unclear. In this study, we aimed to elucidate long-term on post-MI dysfunction.Mice underwent either MI surgery or sham operation. At 1 week after MI, both mice were gavaged with 25 mg/kg/d synthetic agonist...
Long-term exercise-induced metabolic adaptations occupy a central position in exercise-afforded cardiac benefits. Emerging evidence suggests that branched-chain amino acid (BCAA) catabolic defect contributes to dysfunction multiple cardiometabolic diseases. However, the role of BCAA catabolism benefits remains unknown. Here, we show exercise improves and thus reduce vulnerability myocardial ischemic injury. Exercise increased circulating levels both humans (male adolescent athletes) mice...
Low back pain is thought to be mainly caused by intervertebral disc degeneration (IVDD), and there a lack of effective treatments. Cellular senescence matrix degradation are important factors that cause degeneration. Mitochondrial dysfunction induced oxidative stress an mechanism cellular in the nucleus pulposus (NP), mitophagy can effectively remove damaged mitochondria, restore mitochondrial homeostasis, mitigate damage stress. Optineurin (OPTN) selective receptor, its role remains...
Natural aggressiveness is commonly observed in all animal species, and displayed frequently when animals compete for food, territory mating. Aggression an innate behaviour, influenced by both environmental genetic factors. However, the genetics of aggression remains largely unclear. In this study, we identify peacefulness (pfs) gene as a novel player control male-male Drosophila. Mutations pfs decreased intermale aggressiveness, but did not affect locomotor activity, olfactory avoidance...
ABSTRACT Cellular senescence impedes cancer progression by limiting uncontrolled cell proliferation. To identify new genetic events controlling senescence, we performed a small interfering RNA screening human cells and identified number of targets potentially involved in MDA‐MB‐231 breast cells. Importantly, showed that knockdown RAD21 resulted the appearance several senescent markers, including enhanced senescence‐associated β‐galactosidase activity heterochromatin focus formation, as well...
The study aimed to isolate Lactobacillaceae strains with in vitro hypoglycemic activity and probiotic properties determine their antidiabetic abilities vivo. Lactiplantibacillus plantarum 22, L. 25, Limosilactobacillus fermentum 11, 305 high were screened from 23 of isolated human feces identified by 16S rDNA sequencing. fasting blood glucose (FBG) the mice was recorded weekly. After 12 weeks, liver, kidney, pancreas tissues stained hematoxylin eosin (H&E) observe histomorphology;...
Breast cancer is a significant public health issue worldwide, being the most prevalent among women and leading cause of death related to this disease. The molecular processes that propel breast progression are not fully elucidated, highlighting intricate nature underlying biology its crucial impact on global health. objective research was perform bioinformatics analyses cancer-related datasets gain comprehensive understanding mechanisms at play identify key genes associated with toolkit...
Clinical trials, although academically accepted as the most effective treatment available for cancer patients, poor accrual to clinical trials remains a significant problem. A navigator (CTN) program was piloted where patients and/or their healthcare professionals could request search and provide list of potential in which patient may be eligible based on current status disease.This study examined outcomes pilot try improve with focus at medium small sized programs. Outcomes included...
High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) is still a consolidation treatment choice for relapsed/refractory B-cell non-Hodgkin's lymphoma (NHL) patients and some aggressive NHL as frontline therapy. Due to the shortage of carmustine, we switched idarubicin-substituted BEAC (IEAC) conditioning regimen. We retrospectively compared outcomes 72 treated with IEAC or regimens ASCT upfront consolidative treatment. The median time neutrophil...
Objective To compare the effectiveness and practicality of pedicle screw fixation via Quadrant retractor Buck's technique in treatment adolescent spondylolysis. Methods A total 31 patients who underwent or at our hospital from 2012 to 2017 were selected for this retrospective study. The divided into a group (16 patients) (15 according surgical procedure. Age, sex, disease duration, involved segments, preoperative Oswestry disability index (ODI) scores, visual analogue scale (VAS) scores low...
Summary Bone marrow mesenchymal stromal cells (BM‐MSCs) are implicated in the pathogenesis of acute myeloid leukaemia (AML). However, due to high heterogeneity AML mechanism underlying cross‐talk between MSCs and is not well understood. We found that mixed‐lineage leukaemia‐AF9 (MLL‐AF9)‐induced mice‐derived had higher proliferative viability compared wild‐type with ubiquitin‐conjugating enzyme E2O ( Ube2o ) down‐regulation. After overexpression UBE2O AML‐derived MSCs, growth capacity was...
Multiple myeloma is an incurable clonal B-cell malignancy which may present with neoplastic monoclonal plasma cells in either bone or soft tissues. Central nervous system (CNS) involvement such as dural intraparenchymal infiltration, diffuse leptomeningeal involvement, uncommon. Dural of without parenchymal disease even rarer occurrence; therefore there are no established treatment guidelines for CNS myelomatosis. Here we reported a refractory MM patient progressed to dura mater after the...
Primary bone marrow diffuse large B cell lymphoma (DLBCL) is an independent pathologic type with a poor prognosis when treated standard chemoimmunotherapy. Generally, rituximab-based high-dose chemotherapy regimens such as dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-EPOCH) can be administered to young patients, followed by autologous stem transplantation. For elderly the rituximab, doxorubicin, prednisolone (R-CHOP) regimen well tolerated, but it...
Abstract The development of acute lymphoblastic leuakemia (ALL) is partly attributed to the effects bone marrow (BM) microenvironment, especially mesenchymal stromal cells (MSCs), which interact bilaterally with leukaemia cells, leading ALL progression. In order find MSCs-based microenvironment targeted therapeutic strategies, Notch1-induced T-cell (T-ALL) mice models were used and dynamic alterations BM-MSCs increased cell viability during T-ALL was observed. derived stroma-based condition,...