A5101912968- Tryptophan and brain disorders
- Gut microbiota and health
- Bone Metabolism and Diseases
- Diet and metabolism studies
- Heme Oxygenase-1 and Carbon Monoxide
- Neurogenetic and Muscular Disorders Research
- Reproductive System and Pregnancy
- Pharmacological Effects and Toxicity Studies
- Bipolar Disorder and Treatment
- Microbial Metabolites in Food Biotechnology
- PARP inhibition in cancer therapy
- Cytokine Signaling Pathways and Interactions
- Natural Antidiabetic Agents Studies
- NF-κB Signaling Pathways
- Gynecological conditions and treatments
- Chronic Lymphocytic Leukemia Research
- Bioactive natural compounds
- Probiotics and Fermented Foods
- Biological and pharmacological studies of plants
- Whipple's Disease and Interleukins
- Endoplasmic Reticulum Stress and Disease
- Memory and Neural Mechanisms
- Biochemical Acid Research Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Wnt/β-catenin signaling in development and cancer
Affiliated Hospital of Guizhou Medical University
2017-2025
Guiyang Medical University
2017-2025
Beijing Union University
2023-2024
Henan Provincial People's Hospital
2023
Zhengzhou University
2023
Taizhou People's Hospital
2022
Nantong University
2022
Tianjin University
2007
Objective Depression may be accompanied by cognitive impairment, but its pathogenesis remains unclear. This study aims to investigate the protective effects of fluoxetine on behavioral performance and prefrontal cortex neuronal damage in rats with depression-associated based observation VGLUT2 protein expression. Methods Forty-five SPF-grade male SD were randomly divided into three groups ( n = 15): normal control group (CON), depression (DD), (DD + F). The CON was reared normally, while DD...
Background: Endoplasmic reticulum stress (ERS) has been recently suggested to be activated in the major depressive disorder (MDD). However, whether ERS is a potential therapeutic target for MDD largely unknown. Here we attempted assess preventive effect of metoprolol (MET), N-acetylcysteine (NAC), and escitalopram (ESC) on chronic unpredictable mild (CUMS)-induced depression investigate mediates antidepressant role these drugs. Method: Forty-five sprague-dawley rats were randomly divided...
There is evidence that atypical antipsychotics (APs) increase risk of osteoporosis in schizophrenia patients, however the mechanism unclear. The aim study was to explore molecular mechanisms about Wnt/β-catenin signal pathway underlying osteal side effects APs. We cultured human osteoblast cell line hFob1. 19 (OB) treatments with olanzapine, risperidone, amisulpride, aripiprazole or resveratrol vitro. OB cells viability detected by assay. apoptosis analyzed flow cytometry (FCM). Further...
Background. Recent studies suggest a correlation between the reduced Sirt-1 expression with Alzheimer’s diseases (AD) and depression, respectively, suggesting possible pathogenic role of altered in neuronal degenerative diseases, such as AD depression. However, molecular mechanisms underlying how reduction impairs functions remain unknown. Methods. We used SK-N-SH neuroblastoma cells to study on physiological roles cells. Gain was achieved by transiently transfecting plasmid. Sirt-1-specific...
Indoleamine 2,3‑dioxygenase (IDO) is one of the most important proteins protecting embryos from mother's immune system during pregnancy; however, little known about regulation expression this protein at maternal‑fetal interface. In current study, chorionic villi and decidua were collected women early stages pregnancy. Samples cultured in medium containing different concentrations 17β‑estradiol estriol respectively, with or without fulvestrant. Western blot analysis and/or immunofluorescent...
Sirt1 is closely related to cells aging, and also plays an important role in diffuse large B-cell lymphoma (DLBCL). However, its mechanism remains unclear. Therefore, we investigated the of mediated drug-resistance DLBCL, while recombinant lentivirus was used regulate gene expression DLBCL cell lines. Subsequently, effect on resistance Adriamycin analyzed vitro. The results show that overexpression confers inhibition sensitized lines cytotoxicity. Additionally, tumor-bearing mice were verify...
Objectives: While evidence that episodes of mania in bipolar I are associated with changes bioenergetic and regional cerebral blood flow (rCBF) velocity (rCBFV), both the regions extent these have not yet been defined. Therefore, we determined pattern perfusion patients using major depressive disorder (MDD) as positive controls healthy participants negative controls. Methods: 20 mania, together 22 MDD 24 volunteers, were recruited for this study. On all participants, Transcranial Doppler...
The study aimed to isolate Lactobacillaceae strains with in vitro hypoglycemic activity and probiotic properties determine their antidiabetic abilities vivo. Lactiplantibacillus plantarum 22, L. 25, Limosilactobacillus fermentum 11, 305 high were screened from 23 of isolated human feces identified by 16S rDNA sequencing. fasting blood glucose (FBG) the mice was recorded weekly. After 12 weeks, liver, kidney, pancreas tissues stained hematoxylin eosin (H&E) observe histomorphology;...
This study aimed to evaluate the effects of
This study aimed to assess the impact of Lactobacillaceae (L or H represents a low high dose), inulin (I), and polydextrose (P) combined with aerobic exercise (A) on composition gut microbiota metabolic profiles in db/db mice. After 12-week intervention, LIP, LIPA, HIPA groups exhibited significant improvements hyperglycemia, glucose tolerance, insulin resistance, inflammatory response, short-chain fatty acid (SCFA) blood lipid levels compared type 2 diabetes mice (MC). treatment, shifted...
This aim of this study was to assess the molecular mechanism osteoporosis in schizophrenia patients with risperidone use. Here, we investigated effects on cellular proliferation and apoptosis a preosteoblast cell line, MC3T3-E1. Cell viability apoptotic rate MC3T3-E1 were detected by counting kit-8 flow cytometry at serial dose different time points, respectively. Bone transformation relevant gene serum osteocalcin (BGP), collagen 1, tumor necrosis factor-α (TNF-α), osteoprotegerin (OPG),...
// Zhen Zhou 1, 2, 3, 5 , Qin Fang 4, Dan Ma 3 Nana Zhe 2 Mei Ren Bingqing Cheng Peifan Li Ping Liu Xiaojing Lin Sishi Tang Xiuying Hu Yudan Liao Yaming Zhang Tingting Lu and Jishi Wang 1 Department of Hematology, Affiliated Hospital Guizhou Medical University, Guiyang 550004, China Key Laboratory Hematological Disease Diagnostic Treatment Centre Province, Provincial Hematopoietic Stem Cell Transplantation Center, 4 Pharmacy, Baiyun Correspondence to: Wang, email: wangjishi9646@163.com...
<title>Abstract</title> Background To observe the changes in cognitive function of depressive model rats after fluoxetine intervention, and further explore correlation between fluoxetine's influence on N-methyl-D-aspartate receptor 2B subunit (NMDAR2B) hippocampus, as well its impact hippocampal neurons. Methods The depression was established using Chronic Unpredictable Mild Stress (CUMS) combined with solitary confinement, followed by intervention upon successful establishment....
Abstract The endometrium is the dynamic layer which functional differentiation, proliferation and regeneration follow by menstruation estrous cycle, receptivity decodialization vital for fertility. Epcam CD9 have been proved expression on embryonic stem (ES) cells, however, functions underpinning roles of in receptivity, regulating estrogen progesterone remain incompletely understood. Fertility women infertility patients cell sample were collected detected flow cytometry, Western blot Q-PCR....