A5091560388- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Testicular diseases and treatments
- Osteoarthritis Treatment and Mechanisms
- Plant Toxicity and Pharmacological Properties
- Peroxisome Proliferator-Activated Receptors
- Cancer-related gene regulation
- Hedgehog Signaling Pathway Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Spinal Fractures and Fixation Techniques
- Infectious Diseases and Tuberculosis
- RNA modifications and cancer
- Bone health and osteoporosis research
- Medical Imaging and Analysis
- Infective Endocarditis Diagnosis and Management
- Healthcare and Venom Research
- Orthopedic Infections and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Vitamin D Research Studies
Xinqiao Hospital
2019-2024
Army Medical University
2019-2024
General Hospital of Central Theater Command
2024
Central Hospital of Wuhan
2024
Abstract Background The N6‐methyladenosine (m6A) dynamics in the progression of intervertebral disc (IVD) aging remain largely unknown. This study aimed to explore distribution and pattern m 6 A modification nucleus pulpous (NP) tissues rats at different ages. Methods Histological staining MRI were performed evaluate degeneration IVD. expression m6A modifiers was analyzed using qRT‐PCR western blot. Subsequently, methylated RNA immunoprecipitation next generation sequencing RNA‐seq conducted...
Enhance recovery after surgery (ERAS) is a new and promising paradigm for spine surgery. The purpose of this study to investigate the effectiveness safety multimodal evidence-based ERAS pathway patients undergoing anterior cervical discectomy fusion (ACDF).The treated with ACDF-ERAS were compared historical cohort who underwent ACDF before implementation. Primary outcome was length stay (LOS). Secondary outcomes included cost, MacNab grading, complication rates 90-day readmission...
The senescence of nucleus pulposus (NP) cells plays a vital role in the pathogenesis intervertebral disc (IVD) degeneration (IDD). NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce premature NP cell senescence. Enhancer zeste homolog 2 (EZH2) is crucial gene regulating aim this study was investigate roles EZH2 NOX4-induced and feedback loop between NOX4.The down-regulation up-regulation NOX4 p16 were observed degenerative discs aging rats. regulated via H3K27me3-p16...
Intervertebral disc degeneration (IDD) is the most common chronic disease. Oxidative stress and apoptosis of nucleus pulposus (NP) cells disrupt intervertebral (IVD) homeostasis, which main cause IDD. Glioma-associated oncogene 1 (Gli1) an important transcription factor in Hedgehog (Hh) pathway. Depletion Gli1 accelerates occurrence development degenerative diseases. This study aimed to explore role aging related depletion progression IDD.The relationship between IDD was studied NP tissues...
Intervertebral disc degeneration (IDD) and ligamentum flavum hypertrophy (LFH) are major causes of degenerative spinal disorders. Comparative proteomic analysis was used to identify differentially expressed proteins (DEPs) in IDD LFH discs compared with normal discs. Subsequent gene ontology term enrichment Kyoto Encyclopedia Genes Genomes pathway the DEPs human or samples were performed biological processes signaling pathways involved LFH. The PI3K‑AKT pathway, advanced glycation...
Abstract Background Despite the wide use of intraoperative neurophysiological monitoring (IONM) in spinal surgeries, efficacy IONM during percutaneous endoscopic transforaminal lumbar interbody fusion (PE-TLIF) surgery detecting postoperative neurological deficits has not been well characterized. Methods MIONM data from 113 consecutive patients who underwent PE-TLIF surgeries between June 2018 and April 2020 were retrospectively reviewed. Postoperative documented analyzed, specificity...
Abstract Background Enhanced recovery after surgery (ERAS) protocols are widely used worldwide. Recently, studies of the ERAS program in spinal subspecialties have been reported. The aim this study was to evaluate impacts minimally invasive microdiscectomy (MD) surgery. Methods This a retrospective cohort patients undergoing MD at single center. From March 2018 2021, 286 were group. A total 140 from 2017 February conventional outcomes included length stay (LOS), postoperative numeric rating...
Disruption of intervertebral disc (IVD) homeostasis caused by oxidative stress and nucleus pulposus cell (NPC) senescence is a main cause degeneration (IDD). The sonic hedgehog (Shh) pathway plays an important role in IVD development, but its roles IDD are unknown. This study aimed to investigate the effects Shh on alleviation related mechanisms. In vivo, effect was studied intraperitoneal injection recombinant (rShh) GANT61 based puncture-induced IDD. GANT61, lentivirus-coated sh-Gli1 rShh...
Abstract The accumulation of metabolites in the intervertebral disc is considered to be an important cause degeneration (IVDD). Lactate, which a metabolite that produced by cellular anaerobic glycolysis, has been proven closely associated with IVDD. However, little known about role lactate nucleus pulposus cell (NPC) senescence and oxidative stress. This study attempted investigate effect on NPC stress as well underlying mechanism. A puncture-induced (PIDD) model was established rats....