A5046375118- Adipose Tissue and Metabolism
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Metabolism, Diabetes, and Cancer
- GaN-based semiconductor devices and materials
- Inflammasome and immune disorders
- Semiconductor materials and devices
- Eicosanoids and Hypertension Pharmacology
- ZnO doping and properties
- Ga2O3 and related materials
- Mitochondrial Function and Pathology
- Advancements in Semiconductor Devices and Circuit Design
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Glycation End Products research
- Phytochemicals and Antioxidant Activities
- Silicon Carbide Semiconductor Technologies
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Metabolomics and Mass Spectrometry Studies
- Advanced Optical Sensing Technologies
- Lipid metabolism and disorders
- Management of metastatic bone disease
- COVID-19 and healthcare impacts
- Sirtuins and Resveratrol in Medicine
Shanghai Fudan Microelectronics (China)
2020-2024
Fudan University
2019-2024
Central Hospital of Zibo
2024
Zhongshan Hospital
2019-2023
Harbin Institute of Technology
2019-2022
Fudan University Shanghai Cancer Center
2010-2022
State Key Laboratory of ASIC and System
2020-2022
Capital University
2020
Capital Medical University
2020
Chinese PLA General Hospital
2020
The branched-chain amino acids (BCAA) accumulated in type 2 diabetes are independent contributors to insulin resistance. activity of α-keto acid dehydrogenase (BCKD) complex, rate-limiting enzyme BCAA catabolism, is reduced diabetic states, which contributes elevated concentrations. However, the mechanisms underlying decreased BCKD remain poorly understood. Here, we demonstrate that mitochondrial phosphatase 2C (PP2Cm), a newly identified increases activity, was significantly downregulated...
Objective We elected to analyze the correlation between pre-treatment apparent diffusion coefficient (ADC) and clinical, histological, immunohistochemical status of rectal cancers. Materials Methods Forty-nine cancer patients who received surgical resection without neoadjuvant therapy were selected that underwent primary MRI diffusion-weighted imaging (DWI). Tumor ADC values determined analyzed identify any correlations these CEA or CA19-9 levels, and/or histological properties tumor....
Sphingosine 1-phosphate (S1P) mediates multiple pathophysiological effects in the cardiovascular system. However, role of S1P signaling pathological cardiac remodeling following myocardial infarction (MI) remains controversial. In this study, we found that greatly increased post-MI, accompanied with a significant upregulation sphingosine kinase-1 (SphK1) and receptor 1 (S1PR1) expression. MI-operated mice, inhibition production by using PF543 (the SphK1 inhibitor) ameliorated dysfunction....
Recent studies have shown that magnetic resonance (MR) radiomic analysis is feasible and has some value in identifying tumor characteristics, but there are few data regarding the role of MR-based features rectal cancer.
Several recent reports have shown irisin protects the heart against ischemia/reperfusion injury. However, effect of on I/R injury in diabetic mice has not been described. The present study was designed to investigate role myocardial ischemia-reperfusion (MI/R) mice.A mouse model diabetes established by feeding wild type or gene-manipulated adult male with a high-fat diet. All received intraperitoneal injection PBS. Thirty minutes after injection, were subjected 30 min ischemia followed 3h...
Myocardial infarction is characterized by cardiomyocyte death and mitochondrial dysfunction induced ischemia. Ferroptosis, a novel form of cell death, has been found to play critical roles under ischemic conditions. Recently, several studies have shown that fibronectin type III domain-containing 5 (FNDC5) its cleaved form, irisin, protect the heart against injury. However, protective effect on ferroptosis impairments still unclear. Thus, our aim was investigate role irisin in cardiomyocytes...
Scope Portulaca oleracea L. extracts (PE) show hypoglycemic function, but the precise mechanism remains obscure. This study is designed to investigate association of antidiabetes effect PE with gut microbiota modulation and BCAAs metabolism. Methods Results The Orbitrap LC‐MS Fusion Lumos Tribrid mass spectrometer employed analyze major compounds in PE. components intestinal microflora diet‐induced/STZ‐treated diabetic mice are analyzed by high‐throughput 16S rRNA genes sequencing. results...
Fenugreek (Trigonella Foenum-Graecum) seeds flavonoids (FSF) have diverse biological activities, while the antidepressant-like effect of FSF has been seldom explored. The aim this study was to evaluate and identify potential molecular mechanisms. LC-MS/MS used for determination FSF. Chronic restraint stress (CRS) establish animal model depression. Observation exploratory behavior in forced swimming test (FST), tail suspension (TST) sucrose preference (SPT) indicated level. serum...
The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI). Irisin, a novel myokine which is cleaved from its precursor fibronectin type III domain-containing protein 5 (FNDC5), believed to be involved in cardioprotective effect, but little was known on injured BM-MSCs and MI repair yet. Here, we investigated whether FNDC5 or irisin could improve the low viability...
Background COVID-19 is generally believed to increase the risk of nosocomial infections, however, there a gap in relevant researches on critically ill patients cardiac care units (CCU). Method This cross-sectional research was conducted tertiary-level non-epidemic hospital Beijing, capital China. The infection rates CCU were assessed prior and during outbreak. Results During pandemic, overall incidence infections decreased by 20.6-percent compared with pre - pandemic period. Specifically,...
<title>Abstract</title> Introduction It has been proved that FNDC5 plays a significant role in energy metabolism, myocardial protection and insulin sensitivity. However, the specific underlying pathways of including glucose lipid metabolism amino acid are unclear so far. Objectives This study objectives were to investigate metabolic consequences FDNC5 knockout mouse muscle liver tissue. Methods Wildtype (WT) KO mice fed either normal or high fat diets (HFD), then global biochemical profiles...
Purpose: To assess the value of maximal extramural depth (EMD) T3 tumor spread on MRI as a potential noninvasive imaging biomarker aggressiveness in rectal cancer, by analyzing relationship between tumoral EMD values and clinical or histological prognostic parameters.In addition, we try to investigate apparent diffusion coefficient (ADC) values.Materials Methods: Ninety cancer patients who underwent primary staging weighted (DWI) were included.Tumor was measured, subgroups based pretreatment...
Our goal was to explore the factors influencing visualization of anterior peritoneal reflections (APRs) using rectal MRI. We evaluated usefulness MRI in measuring distance from anal verge APR and determining relationship between tumor. Clinical imaging data 319 patients who underwent surgery after examination October 2010 December 2013 were retrospectively analyzed. The location tumor evaluated. analysis variance, logistic regression, independent samples t tests, Kappa tests used for...
The vimentin gene is a hallmark of epithelial-to-mesenchymal transition and has been observed to be overexpressed in various types tumor cell line tissue. Previous studies have reported correlations between DNA methylation levels subsequent expression solid tumors, including breast colorectal cancer; however, the best our knowledge, such correlation not for gastric cancer (GC) using Lauren classification. Therefore, present study aimed quantify quantitative (q) methylation-specific...
Hawthorn berry has been proved hypoglycemic effect due to the presence of some α-glucosidase inhibitors. Herein, screening and identifying inhibitors from hawthorn were conducted, results showed polyphenols mainly containing quercetin (74.58%) hyperioside (9.58%) responsible for its bioactivity. In order enhance effect, combined glucose-lowering complex (DEH) consisting polyphenols, D-chiro-inositol (DCI), epigallocatechin gallate (EGCG) was prepared, where three ingredients exerted...
In this work, time-dependent threshold voltage ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${V}_{\text {TH}}$ </tex-math></inline-formula> ) instability of p-GaN gate high electron mobility transistors (HEMTs) under OFF-state drain stress is systematically investigated. An anomalous shift behavior observed with an initial negative followed by a kink and positive upon prolonged time. Through bias-...
Although a number of studies have indicated that the positive expression nucleophosmin (NPM) and trefoil factor 3 (TFF3) is associated with oncogenesis poor prognosis in several tumor types, prognostic value co-expression NPM TFF3 gastric cancer (GC) has not been fully elucidated. Therefore, this study, we aimed to investigate role GC determine their value. We retrospectively reviewed 108 patients who had undergone radical resection. The was detected by immunohistochemistry association...